scPDB - Distribution of Binding site Similarity values of 3dy7 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3dy7	1CX	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3dy7	1CX	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	1.000
3v04	V04	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.669
3v01	3V0	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.656
2p55	MRA	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.650
1s9j	BBM	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.636
3pp1	IZG	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.630
4an3	5Y0	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.616
3e8n	VRA	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.610
3os3	3OS	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.603
3vvh	4BM	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.602
3orn	3OR	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.601
3dv3	MEK	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.597
4an9	2P7	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.583
4anb	YQY	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.574
4an2	EUI	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.562
4lmn	EUI	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.548
3sls	77D	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.547
4l2i	FAD	Electron transfer flavoprotein alpha/beta-subunit	/	0.482
3vnt	0JA	Vascular endothelial growth factor receptor 2	2.7.10.1	0.481
3efl	706	Vascular endothelial growth factor receptor 2	2.7.10.1	0.476
3ama	SKE	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.475
2oiq	STI	Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	0.468
1iep	STI	Tyrosine-protein kinase ABL1	2.7.10.2	0.465
3amb	VX6	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.464
3t1t	GDP	Probable gliding protein mglA	/	0.463
5hi2	BAX	Serine/threonine-protein kinase B-raf	2.7.11.1	0.462
2fle	AI	Protease	/	0.459
3kq7	KQ7	Mitogen-activated protein kinase 14	/	0.457
4eyj	N61	Mitogen-activated protein kinase 13	2.7.11.24	0.457
3cp9	C19	Vascular endothelial growth factor receptor 2	2.7.10.1	0.456
4fsr	HKC	Serine/threonine-protein kinase Chk1	2.7.11.1	0.456
4wq5	ATP	tRNA N6-adenosine threonylcarbamoyltransferase	/	0.453
3qak	UKA	Adenosine receptor A2a	/	0.453
1zgy	BRL	Peroxisome proliferator-activated receptor gamma	/	0.452
2c3q	GTX	Glutathione S-transferase theta-1	2.5.1.18	0.452
2j7t	274	Serine/threonine-protein kinase 10	2.7.11.1	0.452
4jvf	17X	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	/	0.452
3dtw	A96	Vascular endothelial growth factor receptor 2	2.7.10.1	0.451
1hvs	A77	Gag-Pol polyprotein	/	0.450
3okf	NAD	3-dehydroquinate synthase	4.2.3.4	0.450
4bc6	XZN	Serine/threonine-protein kinase 10	2.7.11.1	0.450
4o2z	046	Mitogen-activated protein kinase	/	0.450
2hyy	STI	Tyrosine-protein kinase ABL1	2.7.10.2	0.449
2rg5	279	Mitogen-activated protein kinase 14	/	0.449
4ase	AV9	Vascular endothelial growth factor receptor 2	2.7.10.1	0.449
3nbw	TR4	Ketohexokinase	/	0.448
3ua5	06X	Cytochrome P450 2B6	1.14.13	0.448
4c8b	0LI	Receptor-interacting serine/threonine-protein kinase 2	2.7.11.1	0.448
1k6c	MK1	Gag-Pol polyprotein	3.4.23.16	0.447
3iph	G11	Mitogen-activated protein kinase 14	/	0.447
3nc9	TR3	Ketohexokinase	/	0.447
3qa2	XNA	Ketohexokinase	/	0.447
1fm4	DXC	Major pollen allergen Bet v 1-L	/	0.446
1rl8	RIT	Gag-Pol polyprotein	3.4.23.16	0.446
2qu6	857	Vascular endothelial growth factor receptor 2	2.7.10.1	0.446
2xcl	ANP	Phosphoribosylamine--glycine ligase	/	0.446
3q92	XNB	Ketohexokinase	/	0.446
4kiq	1RA	Mitogen-activated protein kinase 14	/	0.446
3lfb	Z87	Mitogen-activated protein kinase 14	/	0.445
3qw2	NAD	Myo-inositol-1-phosphate synthase (Ino1)	/	0.445
3zk5	Z18	Cytochrome P450 monooxygenase PikC	/	0.445
2duv	371	Cyclin-dependent kinase 2	2.7.11.22	0.443
3b8q	900	Vascular endothelial growth factor receptor 2	2.7.10.1	0.443
3k9v	CPS	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	/	0.443
2idw	017	Protease	/	0.442
3lit	E15	Protease	/	0.442
3zcw	4A2	Kinesin-like protein KIF11	/	0.442
3zpu	M8B	Gag-Pol polyprotein	3.4.23.16	0.442
4aa5	NQB	Mitogen-activated protein kinase 14	/	0.442
3ol5	SAW	Camphor 5-monooxygenase	1.14.15.1	0.441
4mxo	DB8	Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	0.441
1qcj	APT	Antiviral protein I	3.2.2.22	0.440
3hng	8ST	Vascular endothelial growth factor receptor 1	2.7.10.1	0.440