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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3dtwA96Vascular endothelial growth factor receptor 22.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3dtwA96Vascular endothelial growth factor receptor 22.7.10.11.000
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.790
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.605
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.602
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.598
4o2z046Mitogen-activated protein kinase/0.587
2hyySTITyrosine-protein kinase ABL12.7.10.20.586
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.586
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.583
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.581
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.561
3efl706Vascular endothelial growth factor receptor 22.7.10.10.558
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.558
3hng8STVascular endothelial growth factor receptor 12.7.10.10.555
2p2i608Vascular endothelial growth factor receptor 22.7.10.10.539
3hv5R24Mitogen-activated protein kinase 14/0.529
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.529
4aa0AA0Mitogen-activated protein kinase 14/0.528
2og81N8Tyrosine-protein kinase Lck2.7.10.20.526
1iepSTITyrosine-protein kinase ABL12.7.10.20.524
3kq7KQ7Mitogen-activated protein kinase 14/0.524
2xir00JVascular endothelial growth factor receptor 22.7.10.10.516
4eyjN61Mitogen-activated protein kinase 132.7.11.240.503
3ce31FNHepatocyte growth factor receptor2.7.10.10.498
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.497
4eevL1XHepatocyte growth factor receptor2.7.10.10.486
3ctj320Hepatocyte growth factor receptor2.7.10.10.481
3vhkBPKVascular endothelial growth factor receptor 22.7.10.10.480
3eta351Insulin receptor2.7.10.10.478
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.463
3gcsBAXMitogen-activated protein kinase 14/0.462
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.458
4kaoKAOFocal adhesion kinase 12.7.10.20.449
4qrc0LIFibroblast growth factor receptor 42.7.10.10.443
3lfbZ87Mitogen-activated protein kinase 14/0.441