sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 1.000 | |
| 3dk4 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.729 | |
| 1bwc | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.594 | |
| 1grb | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.585 | |
| 3djg | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.554 | |
| 2rab | FAD | Glutathione amide reductase | / | 0.540 | |
| 2r9z | FAD | Glutathione amide reductase | / | 0.531 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.493 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.479 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.475 | |
| 1geu | FAD | Glutathione reductase | 1.8.1.7 | 0.471 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.467 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.466 | |
| 2zz0 | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.461 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.459 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.458 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.457 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.455 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.454 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.452 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.451 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.448 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.448 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.448 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.447 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.447 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.445 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.444 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.443 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.443 | |
| 1rp0 | AHZ | Thiamine thiazole synthase, chloroplastic | / | 0.442 | |
| 2zzc | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.442 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.440 | |
| 4p63 | NAD | Probable deoxyhypusine synthase | 2.5.1.46 | 0.440 |