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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.91.000
1grhFADGlutathione reductase, mitochondrial1.8.1.70.558
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.557
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.556
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.556
3grsFADGlutathione reductase, mitochondrial1.8.1.70.553
1greFADGlutathione reductase, mitochondrial1.8.1.70.551
2v6oFADThioredoxin glutathione reductase/0.551
1grgFADGlutathione reductase, mitochondrial1.8.1.70.548
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.536
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.533
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.533
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.529
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.520
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.514
1graFADGlutathione reductase, mitochondrial1.8.1.70.508
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.505
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.504
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.502
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.483
4j56FADThioredoxin reductase 21.8.1.90.477
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.475
1gerFADGlutathione reductase1.8.1.70.474
1febFADTrypanothione reductase1.8.1.120.472
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.472
1grbFADGlutathione reductase, mitochondrial1.8.1.70.455
4nevFADTrypanothione reductase/0.449
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.446
1zk7FADMercuric reductase1.16.1.10.444
2r9zFADGlutathione amide reductase/0.443
1zx9FADMercuric reductase1.16.1.10.442
1bzlFADTrypanothione reductase1.8.1.120.440