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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3dfcANPDeath-associated protein kinase 12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3dfcANPDeath-associated protein kinase 12.7.11.11.000
3gu6ADPDeath-associated protein kinase 12.7.11.10.581
2yaaATPDeath-associated protein kinase 2/0.558
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.545
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.542
3lltANPProtein serine/threonine kinase-1/0.538
3gu7ADPDeath-associated protein kinase 12.7.11.10.537
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.521
1jklANPDeath-associated protein kinase 12.7.11.10.520
2ijmADPFocal adhesion kinase 12.7.10.20.519
2w4jADPDeath-associated protein kinase 12.7.11.10.509
3gu4ANPDeath-associated protein kinase 12.7.11.10.508
5av2KMPDeath-associated protein kinase 12.7.11.10.506
3gubGUBDeath-associated protein kinase 12.7.11.10.505
3nieANPMitogen-activated protein kinase/0.505
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.497
4ysjADPCalmodulin-like domain protein kinase/0.496
5av3KMPDeath-associated protein kinase 12.7.11.10.495
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.489
1dawANPCasein kinase II subunit alpha2.7.11.10.488
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.488
5auvAGIDeath-associated protein kinase 12.7.11.10.488
1jkkANPDeath-associated protein kinase 12.7.11.10.487
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.485
4anmWULCasein kinase II subunit alpha2.7.11.10.484
5auxKMPDeath-associated protein kinase 12.7.11.10.482
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.479
1dayGNPCasein kinase II subunit alpha2.7.11.10.478
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
2pvnP63Casein kinase II subunit alpha2.7.11.10.477
5dosATPAurora kinase A2.7.11.10.477
4j99ACPFibroblast growth factor receptor 2/0.476
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.476
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.474
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.473
4h3qANPMitogen-activated protein kinase 12.7.11.240.473
4j95ACPFibroblast growth factor receptor 2/0.473
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.472
3ormAGSSerine/threonine protein kinase/0.472
1ig1ANPDeath-associated protein kinase 12.7.11.10.471
1m2pHNACasein kinase II subunit alpha2.7.11.10.471
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.470
5cnoANPEpidermal growth factor receptor2.7.10.10.470
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.469
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.467
4ic7ANPMitogen-activated protein kinase 72.7.11.240.466
3kvxFMYMitogen-activated protein kinase 102.7.11.240.465
4ux9ANPMitogen-activated protein kinase 82.7.11.240.465
4xlvACPInsulin receptor2.7.10.10.464
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.463
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
5av4GENDeath-associated protein kinase 12.7.11.10.463
5e8ySTUTGF-beta receptor type-22.7.11.300.463
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.460
2j0lANPFocal adhesion kinase 12.7.10.20.459
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
3i60E86Mitogen-activated protein kinase 12.7.11.240.459
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.458
4aqc88ATyrosine-protein kinase JAK2/0.458
4hvi19STyrosine-protein kinase JAK32.7.10.20.458
3nynSGVG protein-coupled receptor kinase 62.7.11.160.457
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
2uzbC75Cyclin-dependent kinase 22.7.11.220.456
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.456
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.456
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.456
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.455
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.455
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.455
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.455
5auwQUEDeath-associated protein kinase 12.7.11.10.454
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.453
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4lfiGNPCasein kinase II subunit alpha2.7.11.10.453
5dnrATPAurora kinase A2.7.11.10.453
3orpAGSSerine/threonine protein kinase/0.452
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.452
4hge15VTyrosine-protein kinase JAK2/0.452
5av047XDeath-associated protein kinase 12.7.11.10.452
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4fv6E57Mitogen-activated protein kinase 12.7.11.240.451
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.450
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.448
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.448
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
4fmqANPMitogen-activated protein kinase 12.7.11.240.447
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.447
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.446
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.446
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.445
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
4deeADPAurora kinase A2.7.11.10.445
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.445
4qnyANPMitogen activated protein kinase, putative/0.445
1p4fDRGDeath-associated protein kinase 12.7.11.10.444
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.444
3t8oATPRhodopsin kinase/0.444
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3oroAGSSerine/threonine protein kinase/0.443
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
4fob0USALK tyrosine kinase receptor2.7.10.10.443
1jnkANPMitogen-activated protein kinase 102.7.11.240.442
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.442
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3sheI85MAP kinase-activated protein kinase 32.7.11.10.442
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.442
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.442
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.441
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.441
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4axfANPInositol-pentakisphosphate 2-kinase2.7.1.1580.440
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.440