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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3dauMTXDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3dauMTXDihydrofolate reductase1.5.1.31.000
3ia4MTXDihydrofolate reductase/0.598
4nx6FOLDihydrofolate reductase1.5.1.30.594
2zzaFOLDihydrofolate reductase/0.593
1rx3MTXDihydrofolate reductase1.5.1.30.591
3ix9MTXDihydrofolate reductase1.5.1.30.582
3cd2MTXDihydrofolate reductase1.5.1.30.579
2drcMTXDihydrofolate reductase1.5.1.30.577
1jolFFODihydrofolate reductase1.5.1.30.576
3och2MXDihydrofolate reductase1.5.1.30.574
4nx7FOLDihydrofolate reductase1.5.1.30.573
1rf7DHFDihydrofolate reductase1.5.1.30.566
3drcMTXDihydrofolate reductase1.5.1.30.566
1draMTXDihydrofolate reductase1.5.1.30.560
3dfrMTXDihydrofolate reductase1.5.1.30.558
2fziDH3Dihydrofolate reductase1.5.1.30.557
4dfrMTXDihydrofolate reductase1.5.1.30.557
1vj3TABDihydrofolate reductase1.5.1.30.554
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.554
2fzhDH1Dihydrofolate reductase1.5.1.30.553
1dyjDDFDihydrofolate reductase1.5.1.30.547
1m7aMQUDihydrofolate reductase1.5.1.30.547
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.547
1dg7WRBDihydrofolate reductase1.5.1.30.545
3fy9XCFDihydrofolate reductase1.5.1.30.543
4ixeIXEDihydrofolate reductase1.5.1.30.543
4h9614QDihydrofolate reductase1.5.1.30.542
3qly55VUncharacterized protein/0.541
4ele31IDihydrofolate reductase/0.541
1dhjMTXDihydrofolate reductase1.5.1.30.540
4cd2FOLDihydrofolate reductase1.5.1.30.540
3sa27DRDihydrofolate reductase/0.538
1ddsMTXDihydrofolate reductase1.5.1.30.536
1rb3MTXDihydrofolate reductase1.5.1.30.536
1dajMOTDihydrofolate reductase1.5.1.30.535
1tdrMTXDihydrofolate reductase1.5.1.30.534
3tq9MTXDihydrofolate reductase/0.534
1df7MTXDihydrofolate reductase1.5.1.30.533
4x5gFOLDihydrofolate reductase1.5.1.30.533
1aoeGW3Dihydrofolate reductase1.5.1.30.532
1qzfFOLBifunctional dihydrofolate reductase-thymidylate synthase/0.531
4ixgIXGDihydrofolate reductase1.5.1.30.531
1rg7MTXDihydrofolate reductase1.5.1.30.529
1ly3COGDihydrofolate reductase1.5.1.30.525
1cd2FOLDihydrofolate reductase1.5.1.30.524
4dp3MMVBifunctional dihydrofolate reductase-thymidylate synthase/0.524
4elf35IDihydrofolate reductase/0.523
4h9753SDihydrofolate reductase1.5.1.30.522
1drbMTXDihydrofolate reductase1.5.1.30.521
2qk8MTXDihydrofolate reductase/0.521
2w3vTOPDihydrofolate reductase/0.521
3eel53TUncharacterized protein/0.521
3fl8RARDihydrofolate reductase/0.519
3datMTXDihydrofolate reductase/0.516
3qlrQLRDihydrofolate reductase1.5.1.30.515
3sa16DRDihydrofolate reductase/0.515
4kjjFOLDihydrofolate reductase1.5.1.30.514
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.513
1klkPMDDihydrofolate reductase1.5.1.30.513
4elb34SDihydrofolate reductase/0.513
4ixfIXFDihydrofolate reductase1.5.1.30.512
4h9506UDihydrofolate reductase1.5.1.30.511
1dg5TOPDihydrofolate reductase1.5.1.30.510
1rx2FOLDihydrofolate reductase1.5.1.30.510
3fy8XCFDihydrofolate reductase1.5.1.30.510
3jwcEKBDihydrofolate reductase/0.507
3qlwN22Dihydrofolate reductase1.5.1.30.507
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.506
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.505
4x5fFOLDihydrofolate reductase1.5.1.30.504
3eem53VUncharacterized protein/0.503
3srqQ19Dihydrofolate reductase1.5.1.30.503
1ddrMTXDihydrofolate reductase1.5.1.30.502
2cd2FOLDihydrofolate reductase1.5.1.30.502
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.502
3fywXCFDihydrofolate reductase1.5.1.30.502
3qlzQLZUncharacterized protein/0.502
4elg52JDihydrofolate reductase/0.502
4h9814QUncharacterized protein/0.502
3tqbFOLDihydrofolate reductase/0.501
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.500
4xe606UDihydrofolate reductase1.5.1.30.500
3qlxQLRUncharacterized protein/0.499
3td8D2RDihydrofolate reductase1.5.1.30.498
4m2xTMQDihydrofolate reductase1.5.1.30.498
3frfXCFDihydrofolate reductase1.5.1.30.497
3frdDHFDihydrofolate reductase1.5.1.30.496
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.496
3ql3FOLDihydrofolate reductase1.5.1.30.496
3sruQ26Dihydrofolate reductase1.5.1.30.496
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.495
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.494
4p66MTXDihydrofolate reductase/0.494
3qls55VDihydrofolate reductase1.5.1.30.493
5hi6MTXDihydrofolate reductase/0.493
3jwm5WBDihydrofolate reductase/0.492
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.492
3srwQ27Dihydrofolate reductase1.5.1.30.491
3sai9DRDihydrofolate reductase/0.490
1rc4DDFDihydrofolate reductase1.5.1.30.489
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.489
1diuBDMDihydrofolate reductase1.5.1.30.488
3fyvXCFDihydrofolate reductase1.5.1.30.488
3jw5TOPDihydrofolate reductase/0.488
3eek53SUncharacterized protein/0.487
1e26GPBDihydrofolate reductase1.5.1.30.485
1kmsLIHDihydrofolate reductase1.5.1.30.485
4fgg0U5Dihydrofolate reductase1.5.1.30.485
1rd7FOLDihydrofolate reductase1.5.1.30.484
1s3yTQTDihydrofolate reductase1.5.1.30.484
3eej53RUncharacterized protein/0.484
1re7FOLDihydrofolate reductase1.5.1.30.481
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.481
3cseN22Uncharacterized protein/0.479
4m6l21VDihydrofolate reductase1.5.1.30.479
4x5jFOLDihydrofolate reductase1.5.1.30.479
3r336MEDihydrofolate reductase1.5.1.30.478
4x5iFOLDihydrofolate reductase1.5.1.30.478
3freTOPDihydrofolate reductase1.5.1.30.476
1rb2FOLDihydrofolate reductase1.5.1.30.475
1disBDMDihydrofolate reductase1.5.1.30.474
2fzjDH3Dihydrofolate reductase1.5.1.30.474
3srsM23Dihydrofolate reductase1.5.1.30.474
3tdaPN0Cytochrome P450 2D6/0.474
1dyrTOPDihydrofolate reductase1.5.1.30.473
1ohkCOPDihydrofolate reductase1.5.1.30.473
3clbTMQBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.470
3m08RARDihydrofolate reductase1.5.1.30.470
4fgh0U6Dihydrofolate reductase1.5.1.30.470
5cccDDFDihydrofolate reductase1.5.1.30.469
3a0iAJIGlucokinase2.7.1.20.466
3qyoQ24Dihydrofolate reductase1.5.1.30.466
4elb34RDihydrofolate reductase/0.466
1hfqMOTDihydrofolate reductase1.5.1.30.465
1ly4COQDihydrofolate reductase1.5.1.30.464
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
1jomFFODihydrofolate reductase1.5.1.30.463
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.463
3sgy06WDihydrofolate reductase1.5.1.30.463
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.462
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.462
3d80Q22Dihydrofolate reductase1.5.1.30.462
3oafOAGDihydrofolate reductase1.5.1.30.462
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.462
1m78CLZDihydrofolate reductase1.5.1.30.461
3eigMTXDihydrofolate reductase1.5.1.30.461
3srrQ20Dihydrofolate reductase1.5.1.30.461
4g95OAGDihydrofolate reductase1.5.1.30.461
4ia7BIVVitamin D3 receptor A/0.461
1ia4TQ6Dihydrofolate reductase1.5.1.30.460
3fl9TOPDihydrofolate reductase/0.460
1hfpMOTDihydrofolate reductase1.5.1.30.459
1rx8FOLDihydrofolate reductase1.5.1.30.459
3sh25DRDihydrofolate reductase1.5.1.30.459
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.458
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.457
4cukNAID-lactate dehydrogenase/0.457
4fnyI3KALK tyrosine kinase receptor2.7.10.10.457
3l3rOAGDihydrofolate reductase1.5.1.30.456
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.455
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.455
4hni16WCasein kinase I isoform epsilon2.7.11.10.455
1blzACVIsopenicillin N synthase1.21.3.10.454
1ia3TQ5Dihydrofolate reductase1.5.1.30.454
1z1fSTLResveratrol synthase/0.454
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.454
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.454
3ua506XCytochrome P450 2B61.14.130.454
4elh53IDihydrofolate reductase/0.454
4g8zTOPDihydrofolate reductase1.5.1.30.454
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.453
3s7a684Dihydrofolate reductase1.5.1.30.453
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
4ia2BIVVitamin D3 receptor A/0.453
4jlj1NMDeoxycytidine kinase2.7.1.740.453
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
3p99LNPLanosterol 14-alpha-demethylase/0.452
2hm9TRRDihydrofolate reductase1.5.1.30.451
3new3NEMitogen-activated protein kinase 14/0.451
2hamC33Vitamin D3 receptor/0.450
2hcdBIVVitamin D3 receptor A/0.450
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.450
4fm5DF0Prostaglandin G/H synthase 21.14.99.10.450
1ove358Mitogen-activated protein kinase 14/0.449
3u8hBHPPhospholipase A2, membrane associated/0.449
4bb3KKAIsopenicillin N synthase1.21.3.10.449
4i1nFOLDihydrofolate reductase1.5.1.30.449
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.448
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4iv21GREstrogen receptor/0.448
2hw2RFPRifampin ADP-ribosyl transferase/0.447
2qa2FADPolyketide oxygenase CabE/0.447
3gc9B45Mitogen-activated protein kinase 112.7.11.240.447
3thrC2FGlycine N-methyltransferase2.1.1.200.447
4rupH97Vitamin D3 receptor A/0.447
1db48INPhospholipase A2, membrane associated/0.446
1qiqACCIsopenicillin N synthase1.21.3.10.446
2vn0TDZCytochrome P450 2C8/0.446
3jw3TOPDihydrofolate reductase/0.446
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.446
4o701QKBromodomain-containing protein 4/0.446
1y4lSVRBasic phospholipase A2 homolog 2/0.445
3lu8IQXSerum albumin/0.445
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.445
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4jlk1NODeoxycytidine kinase2.7.1.740.445
4wa9AXITyrosine-protein kinase ABL12.7.10.20.445
1fmjRTLRetinol dehydratase/0.444
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.444
3ddw055Glycogen phosphorylase, liver form2.4.1.10.444
1z6tADPApoptotic protease-activating factor 1/0.443
2bx8AZQSerum albumin/0.443
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.443
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
1dhfFOLDihydrofolate reductase1.5.1.30.442
1n71COAAac(6')-Ii protein/0.442
1wpgADPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.442
2qe4JJ3Estrogen receptor/0.442
2tscCB3Thymidylate synthase/0.442
3kpzZNEVitamin D3 receptor/0.442
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4j6cSTRCytochrome P450 monooxygenase/0.442
1e1nFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.441
1fmlRTLRetinol dehydratase/0.441
1pd9CO4Dihydrofolate reductase1.5.1.30.441
2bu9HFVIsopenicillin N synthase1.21.3.10.441
2w9gTOPDihydrofolate reductase1.5.1.30.441
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.441
3dhoB2MStreptogramin A acetyltransferase2.3.10.441
3dmjGWEPol protein/0.441
3gyf51PDihydrofolate reductase1.5.1.30.441
3p3zP3ZPutative cytochrome P450/0.441
3tmz06XCytochrome P450 2B41.14.14.10.441
4b7xNAPProbable oxidoreductase/0.441
4fhbFOLDihydrofolate reductase1.5.1.30.441
4iw8KN3Estrogen receptor/0.441
4kebFOLDihydrofolate reductase1.5.1.30.441
1ie9VDXVitamin D3 receptor/0.440
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2iogIOGEstrogen receptor/0.440
2wpxACOOrf14/0.440
3fraI2HDihydrofolate reductase1.5.1.30.440
3is9AC7Gag-Pol polyprotein2.7.7.490.440
3s79ASDAromatase1.14.14.140.440
4ej1FOLDihydrofolate reductase1.5.1.30.440
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.440
4ucnMYAGlycylpeptide N-tetradecanoyltransferase/0.440