Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3dat | MTX | Dihydrofolate reductase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3dat | MTX | Dihydrofolate reductase | / | 1.000 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.581 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.580 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.579 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.575 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.571 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.558 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.551 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.549 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.546 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.541 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.539 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.535 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.534 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.533 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.533 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.532 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.530 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.520 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.519 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.519 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 3cse | N22 | Uncharacterized protein | / | 0.516 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.515 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.513 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.509 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.506 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.506 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.505 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.502 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.500 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 4l9k | EHF | Serum albumin | / | 0.498 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.496 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.495 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.495 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.494 | |
| 3qly | 55V | Uncharacterized protein | / | 0.494 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.494 | |
| 3fl9 | TOP | Dihydrofolate reductase | / | 0.489 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 2exc | JNK | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.487 | |
| 3pff | ADP | ATP-citrate synthase | 2.3.3.8 | 0.487 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 3eej | 53R | Uncharacterized protein | / | 0.486 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.485 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 2pml | ANP | Uncharacterized protein | / | 0.484 | |
| 4awi | AQ2 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.484 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.484 | |
| 1cm8 | ANP | Mitogen-activated protein kinase 12 | / | 0.483 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 3eem | 53V | Uncharacterized protein | / | 0.483 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.483 | |
| 1ie4 | T44 | Transthyretin | / | 0.482 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.482 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.481 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.480 | |
| 3wow | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.480 | |
| 4gvj | ADP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.480 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 0.479 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.479 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2c6e | HPM | Aurora kinase A | 2.7.11.1 | 0.478 | |
| 3jw3 | TOP | Dihydrofolate reductase | / | 0.478 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.476 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 2pyw | ADP | Methylthioribose kinase | 2.7.1.100 | 0.476 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.475 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.475 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.475 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.472 | |
| 3f69 | XDR | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.472 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.471 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.471 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.471 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 4qml | ANP | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.471 | |
| 2hen | ADP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.470 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3t8o | ATP | Rhodopsin kinase | / | 0.469 | |
| 4y12 | AGS | Serine/threonine-protein kinase PknG | 2.7.11.1 | 0.469 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.468 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.468 | |
| 3w0s | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.468 | |
| 4ix5 | ANP | Uncharacterized protein | / | 0.468 | |
| 5l8l | ADP | Aurora kinase A | 2.7.11.1 | 0.468 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.466 | |
| 2q5p | 241 | Peroxisome proliferator-activated receptor gamma | / | 0.466 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 4fl3 | ANP | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.466 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.465 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3orl | AGS | Serine/threonine protein kinase | / | 0.465 | |
| 3rpr | 25Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
| 3vth | APC | Carbamoyltransferase | / | 0.465 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2b9f | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.464 | |
| 2bfy | H1N | Aurora kinase B-A | 2.7.11.1 | 0.464 | |
| 2dcn | ADP | 2-keto-3-deoxy-gluconate kinase | / | 0.464 | |
| 3eek | 53S | Uncharacterized protein | / | 0.464 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.464 | |
| 3orm | AGS | Serine/threonine protein kinase | / | 0.464 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1lp4 | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.462 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2qoc | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.462 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4fl2 | ANP | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.462 | |
| 4ysw | FAD | Xanthine dehydrogenase/oxidase | / | 0.462 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.461 | |
| 3eel | 53T | Uncharacterized protein | / | 0.461 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.461 | |
| 1xr1 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.460 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.460 | |
| 3ori | AGS | Serine/threonine protein kinase | / | 0.460 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.460 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.459 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.458 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 4bbe | 3O4 | Tyrosine-protein kinase JAK2 | / | 0.458 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.458 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.457 | |
| 2vwu | 7X1 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.457 | |
| 3lu8 | IQX | Serum albumin | / | 0.457 | |
| 3tti | KBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.457 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.457 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.456 | |
| 1b38 | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2jj1 | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.456 | |
| 2jj1 | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.456 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.456 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.456 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.456 | |
| 4iay | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.456 | |
| 5ce3 | ADP | Protein kinase YopO | / | 0.456 | |
| 5dos | ATP | Aurora kinase A | 2.7.11.1 | 0.456 | |
| 5eg3 | ACP | Fibroblast growth factor receptor 2 | / | 0.456 | |
| 5iqi | GNP | Bifunctional AAC/APH | 2.3.1 | 0.456 | |
| 1f8s | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.455 | |
| 1ir3 | ANP | Insulin receptor | 2.7.10.1 | 0.455 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 3c4z | ADP | Rhodopsin kinase | / | 0.455 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.455 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.455 | |
| 4a4w | YFB | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 4ful | 0VU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 1tz8 | DES | Transthyretin | / | 0.454 | |
| 2e1m | FAD | L-glutamate oxidase | / | 0.454 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.454 | |
| 2zva | 1N1 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.454 | |
| 3ln1 | CEL | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.454 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.454 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 4o1p | ANP | Ribonuclease L | / | 0.454 | |
| 5e92 | ANP | TGF-beta receptor type-2 | 2.7.11.30 | 0.454 | |
| 1f8r | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.453 | |
| 4eor | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 4xx9 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.453 | |
| 5awm | ANP | Stress-activated protein kinase JNK | 2.7.11.24 | 0.453 | |
| 1day | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.452 | |
| 3ort | AGS | Serine/threonine protein kinase | / | 0.452 | |
| 3r0t | FU9 | Casein kinase II subunit alpha | 2.7.11.1 | 0.452 | |
| 3s1c | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.452 | |
| 4jrn | ANP | Rhoptry kinase family protein | / | 0.452 | |
| 4y0x | ADP | Serine/threonine-protein kinase PknG | 2.7.11.1 | 0.452 | |
| 2ptf | FMN | Uncharacterized protein MTH_863 | / | 0.451 | |
| 2pun | ACP | Methylthioribose kinase | 2.7.1.100 | 0.451 | |
| 3ics | COA | Coenzyme A disulfide reductase | / | 0.451 | |
| 4c4f | 7CE | Dual specificity protein kinase TTK | 2.7.12.1 | 0.451 | |
| 4hyu | 1BK | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.451 | |
| 4x2d | ATP | Fic family protein putative filamentation induced by cAMP protein | / | 0.451 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.450 | |
| 2hw1 | ANP | Ketohexokinase | / | 0.450 | |
| 3orp | AGS | Serine/threonine protein kinase | / | 0.450 | |
| 3qts | X46 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.450 | |
| 4b11 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.450 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.450 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.450 | |
| 1equ | EQI | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.449 | |
| 2qoq | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.449 | |
| 2yfe | YFE | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 3k5u | PFQ | Aurora kinase A | 2.7.11.1 | 0.449 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3rep | ATP | Integrin-linked protein kinase | 2.7.11.1 | 0.449 | |
| 3ufw | HW0 | Nitric oxide synthase, brain | 1.14.13.39 | 0.449 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.449 | |
| 4m7v | RAR | Dihydrofolate reductase | / | 0.449 | |
| 1ad5 | ANP | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.448 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.448 | |
| 1q97 | ATP | Serine/threonine-protein kinase SKY1 | 2.7.11.1 | 0.448 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.448 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.448 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.448 | |
| 3g8d | ADP | Biotin carboxylase | 6.3.4.14 | 0.448 | |
| 3hko | ANP | Calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands | / | 0.448 | |
| 3qar | QAR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 3uoy | NAP | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.448 | |
| 4bfm | ANP | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.448 | |
| 4riy | ANP | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.448 | |
| 4wuj | FMN | Glycoside hydrolase family 15, cellulose signaling associated protein envoy | / | 0.448 | |
| 5cvh | ADP | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 1j7l | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.447 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1q8y | ADP | Serine/threonine-protein kinase SKY1 | 2.7.11.1 | 0.447 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.447 | |
| 3hu3 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.447 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3tdv | GDP | Gentamicin resistance protein | / | 0.447 | |
| 3zcw | 4A2 | Kinesin-like protein KIF11 | / | 0.447 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.447 | |
| 5cnn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.447 | |
| 1hk1 | T44 | Serum albumin | / | 0.446 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.446 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.446 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.446 | |
| 3c4w | ATP | Rhodopsin kinase | / | 0.446 | |
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.446 | |
| 3zon | IK1 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.446 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.446 | |
| 4bl1 | ANP | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.446 | |
| 4xey | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.446 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 1j1c | ADP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.445 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.445 | |
| 2b1p | AIZ | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.445 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.445 | |
| 3m09 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3ork | AGS | Serine/threonine protein kinase | / | 0.445 | |
| 4l9i | 8PR | Rhodopsin kinase | / | 0.445 | |
| 4lfi | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 1jkk | ANP | Death-associated protein kinase 1 | 2.7.11.1 | 0.444 | |
| 1o6y | ACP | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.444 | |
| 2bx8 | AZQ | Serum albumin | / | 0.444 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 2oye | IM8 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.444 | |
| 2wle | COA | Polysialic acid O-acetyltransferase | / | 0.444 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3efw | AK8 | Aurora kinase A | 2.7.11.1 | 0.444 | |
| 3o0n | TTP | Vitamin B12-dependent ribonucleotide reductase | / | 0.444 | |
| 3t9f | ADP | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | / | 0.444 | |
| 3w16 | P9J | Aurora kinase A | 2.7.11.1 | 0.444 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.444 | |
| 1bw9 | NAD | Phenylalanine dehydrogenase | / | 0.443 | |
| 2c0o | L2G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.443 | |
| 2wqe | ADP | Aurora kinase A | 2.7.11.1 | 0.443 | |
| 2ync | YNC | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 3bu5 | ATP | Insulin receptor | 2.7.10.1 | 0.443 | |
| 3igo | ANP | Calmodulin-domain protein kinase 1, putative | / | 0.443 | |
| 3jx3 | JI5 | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 3pjt | C2E | Diguanylate cyclase/phosphodiesterase | / | 0.443 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 4fv9 | E71 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.443 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 5auw | QUE | Death-associated protein kinase 1 | 2.7.11.1 | 0.443 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1kgj | FL8 | Transthyretin | / | 0.442 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1sxj | ADP | Replication factor C subunit 5 | / | 0.442 | |
| 2w4j | ADP | Death-associated protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3cgf | JNF | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.442 | |
| 3ntg | D72 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.442 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.442 | |
| 4b8u | IBK | 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase | 4.2.1.59 | 0.442 | |
| 4nm0 | ADP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.442 | |
| 4ork | GDP | Bifunctional AAC/APH | 2.3.1 | 0.442 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 2ghm | LIC | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2xvw | 9NR | Serum albumin | / | 0.441 | |
| 3qx4 | X4B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 4c4h | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.441 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4hgt | 15G | Casein kinase I isoform delta | 2.7.11.1 | 0.441 | |
| 4k33 | ACP | Fibroblast growth factor receptor 3 | 2.7.10.1 | 0.441 | |
| 4lux | QJ8 | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 4n57 | ADP | APH(2'')-Id | / | 0.441 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 5iqf | GDP | Bifunctional AAC/APH | 2.3.1 | 0.441 | |
| 2a19 | ANP | Interferon-induced, double-stranded RNA-activated protein kinase | 2.7.11.1 | 0.440 | |
| 2bdj | HET | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.440 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3b9l | AZZ | Serum albumin | / | 0.440 | |
| 3cgc | COA | Coenzyme A disulfide reductase | / | 0.440 | |
| 3ddp | RC8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3my5 | RFZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.440 | |
| 4dee | ADP | Aurora kinase A | 2.7.11.1 | 0.440 | |
| 4die | C5P | Cytidylate kinase | / | 0.440 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.440 | |
| 4jl6 | ADP | Adenylate kinase | / | 0.440 |