scPDB - Distribution of Binding site Similarity values of 3d80 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3d80	Q22	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3d80	Q22	Dihydrofolate reductase	1.5.1.3	1.000
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.596
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.569
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.565
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.556
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.550
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.544
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.535
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.535
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.531
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.530
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.523
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.522
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.512
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.512
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.511
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.509
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.508
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.505
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.504
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.504
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.503
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.503
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.502
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.502
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.501
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.499
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.498
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.498
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.495
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.486
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.480
3qlz	QLZ	Uncharacterized protein	/	0.478
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.475
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.474
3qlx	QLR	Uncharacterized protein	/	0.474
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.474
3qly	55V	Uncharacterized protein	/	0.473
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.473
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.472
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.470
1u70	MTX	Dihydrofolate reductase	1.5.1.3	0.469
3cse	N22	Uncharacterized protein	/	0.468
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.468
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.466
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.464
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.463
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.461
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.461
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.460
3eel	53T	Uncharacterized protein	/	0.460
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.459
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.457
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.457
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.457
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.457
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.456
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.456
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.455
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.455
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.452
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.451
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.451
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.450
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.450
2w3v	TOP	Dihydrofolate reductase	/	0.449
1yho	TRR	Dihydrofolate reductase	1.5.1.3	0.448
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.447
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.447
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.447
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.444
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.442
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.442
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.440
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.440
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.440
4jib	1L6	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.440