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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3d74NBBPheromone-binding protein ASP1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3d74NBBPheromone-binding protein ASP1/1.000
3d75NBBPheromone-binding protein ASP1/0.558
3d76NBBPheromone-binding protein ASP1/0.547
3d77NBBPheromone-binding protein ASP1/0.543
3d73NBBPheromone-binding protein ASP1/0.533
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.526
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.516
3lfeZ84Mitogen-activated protein kinase 14/0.510
3p9tTCLRepressor/0.507
3bfa9ODOdorant binding protein ASP1/0.505
3nr4PYVAbscisic acid receptor PYL2/0.504
4j6cSTRCytochrome P450 monooxygenase/0.503
4equG6ISerine/threonine-protein kinase 102.7.11.10.501
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.498
3adaNADSubunit alpha of sarocosine oxidase/0.497
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.496
3p99LNPLanosterol 14-alpha-demethylase/0.495
3bfb9ODPheromone-binding protein ASP1/0.493
2zb8IMNProstaglandin reductase 21.3.1.480.492
3tk3CPZCytochrome P450 2B41.14.14.10.491
3vt5YI2Vitamin D3 receptor/0.491
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.491
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.490
2p1u4TNRetinoic acid receptor RXR-alpha/0.489
5bp9SAHPutative methyltransferase protein/0.489
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.488
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.488
3bejMUFBile acid receptor/0.488
4jbtASDCytochrome P450 monooxygenase/0.488
3rfmCFFAdenosine receptor A2a/0.488
1obnASVIsopenicillin N synthase1.21.3.10.487
4j6dTESCytochrome P450 monooxygenase/0.487
2bu9HFVIsopenicillin N synthase1.21.3.10.486
1yhoTRRDihydrofolate reductase1.5.1.30.485
3c3xNAPEugenol synthase 11.1.1.3180.485
3h3sH15Collagen type IV alpha-3-binding protein/0.485
4caxMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.484
5dozNDPJamJ/0.484
2hcdBIVVitamin D3 receptor A/0.483
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.483
2po7CHDFerrochelatase, mitochondrial4.99.1.10.483
3uzaT4GAdenosine receptor A2a/0.483
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.482
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.482
3vtcTK3Vitamin D3 receptor/0.482
3zkyWT4Isopenicillin N synthase1.21.3.10.482
4nb6444Nuclear receptor ROR-gamma/0.482
1klkPMDDihydrofolate reductase1.5.1.30.481
2vn0TDZCytochrome P450 2C8/0.481
3zoiM2WIsopenicillin N synthase1.21.3.10.481
1blzACVIsopenicillin N synthase1.21.3.10.480
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.480
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.480
1dkfBMSRetinoic acid receptor alpha/0.479
1uzwCDHIsopenicillin N synthase1.21.3.10.479
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.479
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.479
4j6bPLOCytochrome P450 monooxygenase/0.479
1xddAAYIntegrin alpha-L/0.478
2dqsTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.478
2jb4A14Isopenicillin N synthase1.21.3.10.478
4m8e29VRetinoic acid receptor RXR-alpha/0.478
2y60M8FIsopenicillin N synthase1.21.3.10.477
5c1mCLRMu-type opioid receptor/0.477
3uzcT4EAdenosine receptor A2a/0.477
1oc1ASVIsopenicillin N synthase1.21.3.10.476
3ad9NADSubunit alpha of sarocosine oxidase/0.476
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.476
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.475
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.475
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.475
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.475
3hv3R49Mitogen-activated protein kinase 14/0.475
3nx4NAPPutative oxidoreductase/0.475
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.474
4ia1BIVVitamin D3 receptor A/0.474
5iua6DXAdenosine receptor A2a/0.474
1mvtDTMDihydrofolate reductase1.5.1.30.473
2w4qCBWProstaglandin reductase 21.3.1.480.473
3gcq1BUMitogen-activated protein kinase 14/0.473
3lu8IQXSerum albumin/0.473
4qa0SHHHistone deacetylase 83.5.1.980.473
1bk0ACVIsopenicillin N synthase1.21.3.10.472
2bakAQZMitogen-activated protein kinase 14/0.472
3u8hBHPPhospholipase A2, membrane associated/0.472
3vrwYS5Vitamin D3 receptor/0.472
4a9yAQZMitogen-activated protein kinase 14/0.472
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
2g78REACellular retinoic acid-binding protein 2/0.471
2iviACWIsopenicillin N synthase1.21.3.10.471
2uxhQUEHTH-type transcriptional regulator TtgR/0.471
2vbpVB1Isopenicillin N synthase1.21.3.10.471
2vcmM11Isopenicillin N synthase1.21.3.10.471
4i8vBHFCytochrome P450 1A11.14.14.10.471
1ezfIN0Squalene synthase2.5.1.210.470
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
2dw4FADLysine-specific histone demethylase 1A10.469
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.469
5k2cZMAAdenosine receptor A2a/0.469
3qakUKAAdenosine receptor A2a/0.469
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.468
1upw444Oxysterols receptor LXR-beta/0.468
3bzuA21Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.468
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.468
3hz5Z64Heat shock protein HSP 90-alpha/0.468
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.468
3up0D7SaceDAF-12/0.468
4fhi0S4Vitamin D3 receptor A/0.468
1hb1OCVIsopenicillin N synthase1.21.3.10.467
1pd9CO4Dihydrofolate reductase1.5.1.30.467
2c7xNRBCytochrome P450 monooxygenase PikC/0.467
2hamC33Vitamin D3 receptor/0.467
2hb7O1CVitamin D3 receptor/0.467
2iltNN1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.467
2p1t3TNRetinoic acid receptor RXR-alpha/0.467
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.467
3is9AC7Gag-Pol polyprotein2.7.7.490.467
3p6nDSOCamphor 5-monooxygenase1.14.15.10.467
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.467
4bfxZVXPantothenate kinase2.7.1.330.467
4dm6TTBRetinoic acid receptor beta/0.467
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.467
1l2jETCEstrogen receptor beta/0.466
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.466
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.466
4cavMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.466
4g210VPVitamin D3 receptor A/0.466
5bsrCOA4-coumarate--CoA ligase 26.2.1.120.466
1ie8KH1Vitamin D3 receptor/0.465
2ij7TPFMycocyclosin synthase1.14.21.90.465
2y6fM9FIsopenicillin N synthase1.21.3.10.465
3tmz06XCytochrome P450 2B41.14.14.10.465
3uvvREARetinoic acid receptor RXR-alpha/0.465
4ict1EDMycocyclosin synthase1.14.21.90.465
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.465
2ewaSB2Mitogen-activated protein kinase 14/0.464
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.464
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.464
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.464
3gw9VNILanosterol 14-alpha-demethylase/0.464
3wv9FEGHmd co-occurring protein HcgE/0.464
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.464
4fhh0U3Vitamin D3 receptor A/0.464
4g95OAGDihydrofolate reductase1.5.1.30.464
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.464
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
1pkfEPDEpothilone C/D epoxidase1.140.463
1tv8SAMGTP 3',8-cyclase4.1.99.180.463
2aclL05Oxysterols receptor LXR-alpha/0.463
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
2vbdV10Isopenicillin N synthase1.21.3.10.463
3a783EVVitamin D3 receptor/0.463
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
3hf6LX0Tryptophan 5-hydroxylase 11.14.16.40.463
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.463
3vhuSNLMineralocorticoid receptor/0.463
3w0aDS5Vitamin D3 receptor/0.463
3w0iO11Vitamin D3 receptor/0.463
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.463
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.463
4enhFVXCholesterol 24-hydroxylase/0.463
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.463
1crbRTLRetinol-binding protein 1/0.462
1dd6MCIMetallo-beta-lactamase type 2/0.462
1drfFOLDihydrofolate reductase1.5.1.30.462
1qiqACCIsopenicillin N synthase1.21.3.10.462
1s3vTQDDihydrofolate reductase1.5.1.30.462
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.462
3abaFLICytochrome P450/0.462
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.462
3c1xCKKHepatocyte growth factor receptor2.7.10.10.462
3cth319Hepatocyte growth factor receptor2.7.10.10.462
3i0rRT3Gag-Pol polyprotein2.7.7.490.462
3l0lHC3Nuclear receptor ROR-gamma/0.462
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.462
1fp1HCCIsoliquiritigenin 2'-O-methyltransferase/0.461
1k749CRRetinoic acid receptor RXR-alpha/0.461
1ly4COQDihydrofolate reductase1.5.1.30.461
1n83CLRNuclear receptor ROR-alpha/0.461
1pr1FMBPurine nucleoside phosphorylase DeoD-type/0.461
1q5dEPBEpothilone C/D epoxidase1.140.461
1s19MC9Vitamin D3 receptor/0.461
1s3uTQDDihydrofolate reductase1.5.1.30.461
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.461
1w22NHBHistone deacetylase 83.5.1.980.461
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
2za0MGILactoylglutathione lyase4.4.1.50.461
3bjhNBBOdorant binding protein ASP1/0.461
3gkjHC3Niemann-Pick C1 protein/0.461
3vtbTKAVitamin D3 receptor/0.461
4eevL1XHepatocyte growth factor receptor2.7.10.10.461
4ia7BIVVitamin D3 receptor A/0.461
4jlk1NODeoxycytidine kinase2.7.1.740.461
4u2lSFDCholesterol oxidase1.1.3.60.461
1e7aPFLSerum albumin/0.460
1uwhBAXSerine/threonine-protein kinase B-raf2.7.11.10.460
1uy6PU3Heat shock protein HSP 90-alpha/0.460
2j9lATPH(+)/Cl(-) exchange transporter 5/0.460
3fzsB96Protein-tyrosine kinase 2-beta2.7.10.20.460
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.460
3up3XCAaceDAF-12/0.460
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.460
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.460
4iae1DXAlr2278 protein/0.460
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.460
1ly3COGDihydrofolate reductase1.5.1.30.459
1mvsDTMDihydrofolate reductase1.5.1.30.459
1n4uFAECholesterol oxidase1.1.3.60.459
1zg32HIIsoflavone 4'-O-methyltransferase/0.459
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.459
2vzmNRBCytochrome P450 monooxygenase PikC/0.459
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
3nj0PYVAbscisic acid receptor PYL2/0.459
3p3zP3ZPutative cytochrome P450/0.459
3td8D2RDihydrofolate reductase1.5.1.30.459
3uk6ADPRuvB-like 23.6.4.120.459
3vt9YI4Vitamin D3 receptor/0.459
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.459
5k2bZMAAdenosine receptor A2a/0.459
1tg56454-hydroxyphenylpyruvate dioxygenase1.13.11.270.458
3ffi3OBGag-Pol polyprotein2.7.7.490.458
3sl2ATPSensor histidine kinase WalK/0.458
4cdmFO1Deoxyribodipyrimidine photolyase/0.458
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4g3jVNTLanosterol 14-alpha-demethylase/0.458
4nh92LCEndoplasmin/0.458
1olmVTQSEC14-like protein 2/0.457
1uhlMEIRetinoic acid receptor RXR-beta/0.457
1xiuREARetinoic acid receptor RXR/0.457
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.457
2uxoTACHTH-type transcriptional regulator TtgR/0.457
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.457
3ctj320Hepatocyte growth factor receptor2.7.10.10.457
3ibdCPZCytochrome P450 2B61.14.130.457
3kpzZNEVitamin D3 receptor/0.457
3njoPYVAbscisic acid receptor PYR1/0.457
4jlj1NMDeoxycytidine kinase2.7.1.740.457
4l8u9AZSerum albumin/0.457
1hb3SCVIsopenicillin N synthase1.21.3.10.456
1n4hREANuclear receptor ROR-beta/0.456
1thnADPAnti-sigma F factor/0.456
2hm9TRRDihydrofolate reductase1.5.1.30.456
3qly55VUncharacterized protein/0.456
3w0yDS4Vitamin D3 receptor/0.456
4c0bATPmRNA cleavage and polyadenylation factor CLP1/0.456
4eftEFTHeat shock protein HSP 90-alpha/0.456
4ia3BIVVitamin D3 receptor A/0.456
4jdaA9SAbscisic acid receptor PYL3/0.456
4qbjNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.456
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.456
3reyXACAdenosine receptor A2a/0.456
3emlZMAAdenosine receptor A2a/0.456
1fmjRTLRetinol dehydratase/0.455
2q70DC8Estrogen receptor/0.455
2y30SM8Putative repressor SimReg2/0.455
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
3tdaPN0Cytochrome P450 2D6/0.455
3vt65YIVitamin D3 receptor/0.455
4bfwZVWPantothenate kinase2.7.1.330.455
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4iah1DXAlr2278 protein/0.455
4j4vSVRNucleocapsid protein/0.455
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.455
4k9yK9YFocal adhesion kinase 12.7.10.20.455
5k2aZMAAdenosine receptor A2a/0.455
3sn6P0GBeta-2 adrenergic receptor/0.455
1og5SWFCytochrome P450 2C9/0.454
2p1v5TNRetinoic acid receptor RXR-alpha/0.454
3ar7TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.454
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.454
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.454
3iw8HIZMitogen-activated protein kinase 14/0.454
3p6mDSOCamphor 5-monooxygenase1.14.15.10.454
3vt7VDXVitamin D3 receptor/0.454
3vtdTKDVitamin D3 receptor/0.454
4a31MYAGlycylpeptide N-tetradecanoyltransferase/0.454
4elg52JDihydrofolate reductase/0.454
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4klaCHDFerrochelatase, mitochondrial4.99.1.10.454
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.454
1fm69CRRetinoic acid receptor RXR-alpha/0.453
1jlcFTCGag-Pol polyprotein2.7.7.490.453
1xlsREARetinoic acid receptor RXR-alpha/0.453
2w3vTOPDihydrofolate reductase/0.453
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.453
2yiuSMACytochrome b/0.453
3ipq965Oxysterols receptor LXR-alpha/0.453
3mdmFJZCholesterol 24-hydroxylase/0.453
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.453
3sfi3SFHTH-type transcriptional regulator EthR/0.453
3w0gW07Vitamin D3 receptor/0.453
4ea13RXDehydrosqualene synthase/0.453
4fnyI3KALK tyrosine kinase receptor2.7.10.10.453
4g1z0VPVitamin D3 receptor A/0.453
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
4iteTEYVitamin D3 receptor/0.453
4lsjLSJGlucocorticoid receptor/0.453
4uyf73BBromodomain-containing protein 2/0.453
1fbyREARetinoic acid receptor RXR-alpha/0.452
1x8b824Wee1-like protein kinase2.7.10.20.452
1xu9CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
2harOCCVitamin D3 receptor/0.452
2io6330Wee1-like protein kinase2.7.10.20.452
2ph5NADHomospermidine synthase/0.452
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.452
2zb1GK4Mitogen-activated protein kinase 14/0.452
2zb45OPProstaglandin reductase 21.3.1.480.452
3gc9B45Mitogen-activated protein kinase 112.7.11.240.452
3ls8AJZPhosphatidylinositol 3-kinase catalytic subunit type 32.7.1.1370.452
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
3p6pA6BCamphor 5-monooxygenase1.14.15.10.452
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.452
3vrvYSDVitamin D3 receptor/0.452
4at0FADPossible succinate dehydrogenase/0.452
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.452
4jx1CAMCamphor 5-monooxygenase1.14.15.10.452
4mv4ACPBiotin carboxylase6.3.4.140.452
4nieNBHNuclear receptor ROR-gamma/0.452
4y8vADPAcyl-CoA synthetase (NDP forming)/0.452
5dp2NAPCurF/0.452
5jtbZMAAdenosine receptor A2a/0.452
1dhfFOLDihydrofolate reductase1.5.1.30.451
1kyzFERCaffeic acid 3-O-methyltransferase2.1.1.680.451
1m9m6NINitric oxide synthase, endothelial1.14.13.390.451
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
2hc4VDXVitamin D3 receptor A/0.451
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.451
2vcgS17Histone deacetylase-like amidohydrolase3.5.10.451
3a1l2CCCytochrome P450/0.451
3fl8RARDihydrofolate reductase/0.451
3h0a9RARetinoic acid receptor RXR-alpha/0.451
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.451
3q0gBCOProbable enoyl-CoA hydratase echA84.2.1.170.451
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.451
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.451
4ia2BIVVitamin D3 receptor A/0.451
4k6i9RARetinoic acid receptor RXR-alpha/0.451
4qx5CMPcGMP-dependent protein kinase 12.7.11.120.451
4uymVOR14-alpha sterol demethylase Cyp51B/0.451
5ckwANPUncharacterized protein/0.451
5uviZMAAdenosine receptor A2a/0.451
1e1qADPATP synthase subunit beta, mitochondrial3.6.3.140.450
1mc5AHEAlcohol dehydrogenase class-31.1.1.10.450
1pqc444Oxysterols receptor LXR-beta/0.450
1txiTX5Vitamin D3 receptor/0.450
1w06W05Isopenicillin N synthase1.21.3.10.450
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2hb8MVDVitamin D3 receptor/0.450
2pulACPMethylthioribose kinase2.7.1.1000.450
2q9fC3SCholesterol 24-hydroxylase/0.450
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.450
2v7qADPATP synthase subunit beta, mitochondrial3.6.3.140.450
2xk3XK3Serine/threonine-protein kinase Nek22.7.11.10.450
3cseN22Uncharacterized protein/0.450
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
3oafOAGDihydrofolate reductase1.5.1.30.450
3oapREARetinoic acid receptor RXR-alpha/0.450
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.450
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4g1y0VOVitamin D3 receptor A/0.450
4iw8KN3Estrogen receptor/0.450
4qe6JN3Bile acid receptor/0.450
4xe606UDihydrofolate reductase1.5.1.30.450
1cbsREACellular retinoic acid-binding protein 2/0.449
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1iyzNDPProbable quinone oxidoreductase/0.449
1kmvLIIDihydrofolate reductase1.5.1.30.449
1m7aMQUDihydrofolate reductase1.5.1.30.449
1o6rR19Squalene--hopene cyclase4.2.1.1290.449
1rgsCMPcAMP-dependent protein kinase type I-alpha regulatory subunit/0.449
2aibERGBeta-elicitin cinnamomin/0.449
2dvlFADAcyl-CoA dehydrogenase/0.449
2hw2RFPRifampin ADP-ribosyl transferase/0.449
2oaxSNLMineralocorticoid receptor/0.449
2rbeZMGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
2xlsFADPutative flavin-containing monooxygenase/0.449
2z2w770Wee1-like protein kinase2.7.10.20.449
2zl9VDAVitamin D3 receptor/0.449
3cbsR12Cellular retinoic acid-binding protein 2/0.449
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.449
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
3pqbVGPPutative oxidoreductase/0.449
3v94WYQPhosphodiesterase/0.449
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.449
4g1d0VKVitamin D3 receptor A/0.449
4gueQCTRibosomal protein S6 kinase alpha-32.7.11.10.449
4jln18VDeoxycytidine kinase2.7.1.740.449
4lb2DM5Serum albumin/0.449
1p8dCO1Oxysterols receptor LXR-beta/0.448
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2nq8ZIDEnoyl-ACP reductase/0.448
2o4rVD5Vitamin D3 receptor/0.448
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.448
2olcADPMethylthioribose kinase2.7.1.1000.448
2owb626Serine/threonine-protein kinase PLK12.7.11.210.448
2pl0STITyrosine-protein kinase Lck2.7.10.20.448
2y37A54Nitric oxide synthase, inducible1.14.13.390.448
2yac937Serine/threonine-protein kinase PLK12.7.11.210.448
3ghwGHWDihydrofolate reductase1.5.1.30.448
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.448
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
3qeoLLTDeoxycytidine kinase2.7.1.740.448
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.448
3ua506XCytochrome P450 2B61.14.130.448
4ap1NAPSteroid monooxygenase/0.448
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4dscA8SAbscisic acid receptor PYL3/0.448
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
5bt42LOBromodomain-containing protein 4/0.448
1al8DHPPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.447
1kl2FONSerine hydroxymethyltransferase/0.447
1mvcBM6Retinoic acid receptor RXR-alpha/0.447
1nzyBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.447
1rk3VDXVitamin D3 receptor/0.447
1tl7ONMAdenylate cyclase type 2/0.447
1tl7ONMAdenylate cyclase type 5/0.447
1vrwNAIEnoyl-ACP reductase/0.447
1zgaHMKIsoflavone 4'-O-methyltransferase/0.447
2ban357Gag-Pol polyprotein2.7.7.490.447
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.447
2ydoADNAdenosine receptor A2a/0.447
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3lkhLT6Genome polyprotein2.7.7.480.447
3otqMZLBifunctional epoxide hydrolase 23.3.2.100.447
3s7a684Dihydrofolate reductase1.5.1.30.447
4b7sQLECytochrome P450 monooxygenase PikC/0.447
4itfTFYVitamin D3 receptor/0.447
4p6wMOFGlucocorticoid receptor/0.447
1ek2CDUBifunctional epoxide hydrolase 2/0.446
1rf9DBRCamphor 5-monooxygenase1.14.15.10.446
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.446
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.446
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.446
2vf0F89Thymidylate synthase/0.446
2ykcYKCHeat shock protein HSP 90-alpha/0.446
2ze2T27Gag-Pol polyprotein2.7.7.490.446
3a7dFBNCatechol O-methyltransferase2.1.1.60.446
3l6jZ90Alr2278 protein/0.446
3w0hW12Vitamin D3 receptor/0.446
4bfuZVUPantothenate kinase2.7.1.330.446
4ddrMMVDihydrofolate reductase1.5.1.30.446
4elb34SDihydrofolate reductase/0.446
4g47TZFMycocyclosin synthase1.14.21.90.446
4i7fNVEGag-Pol polyprotein2.7.7.490.446
4jlm1NNDeoxycytidine kinase2.7.1.740.446
5dq8FLFTranscriptional enhancer factor TEF-4/0.446
1cbrREACellular retinoic acid-binding protein 1/0.445
1db1VDXVitamin D3 receptor/0.445
1r9oFLPCytochrome P450 2C9/0.445
1rdtL79Retinoic acid receptor RXR-alpha/0.445
1rkgVD1Vitamin D3 receptor/0.445
1rkhVD2Vitamin D3 receptor/0.445
1sqvUHDCytochrome b/0.445
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.445
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.445
3fznD7KBenzoylformate decarboxylase4.1.1.70.445
3hz142CHeat shock protein HSP 90-alpha/0.445
3qlwN22Dihydrofolate reductase1.5.1.30.445
3qm4PN0Cytochrome P450 2D6/0.445
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4eiyZMAAdenosine receptor A2a/0.445
4g1nNZTPyruvate kinase PKM2.7.1.400.445
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.445
5d1bTSNHistone deacetylase 83.5.1.980.445
5fm7ADPRuvB-like helicase/0.445
1i5cADPChemotaxis protein CheA2.7.13.30.444
1mznBM6Retinoic acid receptor RXR-alpha/0.444
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1re9DSOCamphor 5-monooxygenase1.14.15.10.444
1s0zEB1Vitamin D3 receptor/0.444
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2hasC3OVitamin D3 receptor/0.444
2jj1ADPATP synthase subunit alpha, mitochondrial/0.444
2jj1ADPATP synthase subunit beta, mitochondrial3.6.3.140.444
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.444
2ykbYKBHeat shock protein HSP 90-alpha/0.444
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.444
3ce31FNHepatocyte growth factor receptor2.7.10.10.444
3e6oA55Nitric oxide synthase, inducible1.14.13.390.444
3h4vDVPPteridine reductase 11.5.1.330.444
3iiuPIDPeridinin-chlorophyll a-binding protein 1, chloroplastic/0.444
3p6oETGCamphor 5-monooxygenase1.14.15.10.444
3qls55VDihydrofolate reductase1.5.1.30.444
3sai9DRDihydrofolate reductase/0.444
3u4uLNHCasein kinase II subunit alpha2.7.11.10.444
3ufl508Beta-secretase 13.4.23.460.444
3w0c6DSVitamin D3 receptor/0.444
3w5p4OAVitamin D3 receptor/0.444
3zbnCOA3-ketoacyl-CoA thiolase-like protein/0.444
4bqg50QHeat shock protein HSP 90-alpha/0.444
4ele31IDihydrofolate reductase/0.444
4g2h0VQVitamin D3 receptor A/0.444
4ips1G4Mycocyclosin synthase1.14.21.90.444
4jv618FRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.444
4k4j1O8Retinoic acid receptor RXR-alpha/0.444
4kebFOLDihydrofolate reductase1.5.1.30.444
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
4oztP1AEcdysone receptor, putative/0.444
4twnB96Ephrin type-A receptor 32.7.10.10.444
5ag5MYAGlycylpeptide N-tetradecanoyltransferase/0.444
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.444
1cbqRE9Cellular retinoic acid-binding protein 2/0.443
1ee0CAA2-pyrone synthase/0.443
1ot7IU5Bile acid receptor/0.443
1vrqFONSubunit alpha of sarocosine oxidase/0.443
1vruAAPGag-Pol polyprotein2.7.7.490.443
1zeoC01Peroxisome proliferator-activated receptor gamma/0.443
2euhNAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase1.2.1.90.443
2jn3JN3Fatty acid-binding protein, liver/0.443
2nmtNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.443
2oh4GIGVascular endothelial growth factor receptor 22.7.10.10.443
2vqoTFGHistone deacetylase 43.5.1.980.443
2ykiYKIHeat shock protein HSP 90-alpha/0.443
3biz61EWee1-like protein kinase2.7.10.20.443
3i0sRT7Gag-Pol polyprotein2.7.7.490.443
3jwm5WBDihydrofolate reductase/0.443
3l8sBFFMitogen-activated protein kinase 14/0.443
3mdvCL6Cholesterol 24-hydroxylase/0.443
3pe2E1BCasein kinase II subunit alpha2.7.11.10.443
3sgy06WDihydrofolate reductase1.5.1.30.443
4a83DXCMajor pollen allergen Bet v 1-A/0.443
4a84DXCMajor pollen allergen Bet v 1-A/0.443
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.443
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4iarERM5-hydroxytryptamine receptor 1B/0.443
4ig01FGGag-Pol polyprotein2.7.7.490.443
4qa2SHHHistone deacetylase 83.5.1.980.443
4r20AERCytochrome P450 family 17 polypeptide 2/0.443
4ruoBIVVitamin D3 receptor A/0.443
4tyj0LIFibroblast growth factor receptor 42.7.10.10.443
4xbfFADLysine-specific histone demethylase 1A10.443
5cyqT27Gag-Pol polyprotein2.7.7.490.443
1dajMOTDihydrofolate reductase1.5.1.30.442
1eetBFUGag-Pol polyprotein2.7.7.490.442
1errRALEstrogen receptor/0.442
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.442
1sqbAZOCytochrome b/0.442
2in6839Wee1-like protein kinase2.7.10.20.442
2jizANPATP synthase subunit beta, mitochondrial3.6.3.140.442
2wd8VGFPteridine reductase/0.442
3bhrTHGThymidylate synthase/0.442
3iaeD7KBenzaldehyde lyase/0.442
3new3NEMitogen-activated protein kinase 14/0.442
3s3vTOPDihydrofolate reductase1.5.1.30.442
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.442
3t8xT8XT-cell surface glycoprotein CD1b/0.442
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.442
4a87NARMajor pollen allergen Bet v 1-A/0.442
4a9mP9MBromodomain-containing protein 2/0.442
4c3yANB3-ketosteroid dehydrogenase/0.442
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4elf35IDihydrofolate reductase/0.442
4h9753SDihydrofolate reductase1.5.1.30.442
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.442
4jvlESTEstrogen sulfotransferase2.8.2.40.442
4m8hR4MRetinoic acid receptor RXR-alpha/0.442
4mleVO1Glucokinase2.7.1.20.442
4q71FADBifunctional protein PutA/0.442
4yaoFMNNADPH--cytochrome P450 reductase/0.442
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.442
1al7HSTPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.441
1cc2FADCholesterol oxidase1.1.3.60.441
1e3vDXCSteroid Delta-isomerase5.3.3.10.441
1eioGCHGastrotropin/0.441
1fwmCB3Thymidylate synthase/0.441
1ia3TQ5Dihydrofolate reductase1.5.1.30.441
1kzjCB3Thymidylate synthase/0.441
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.441
1rjkVDZVitamin D3 receptor/0.441
1zdwFLVPrenyltransferase/0.441
2aclREARetinoic acid receptor RXR-alpha/0.441
2fziDH3Dihydrofolate reductase1.5.1.30.441
2g274LGRenin3.4.23.150.441
2rjp886A disintegrin and metalloproteinase with thrombospondin motifs 43.4.24.820.441
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.441
3deiRXBCaspase-33.4.22.560.441
3drcMTXDihydrofolate reductase1.5.1.30.441
3ft8MOJHeat shock protein HSP 90-alpha/0.441
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.441
3l3rOAGDihydrofolate reductase1.5.1.30.441
3naxMP73-phosphoinositide-dependent protein kinase 12.7.11.10.441
3otwCOAPhosphopantetheine adenylyltransferase/0.441
3sa27DRDihydrofolate reductase/0.441
3tdl11DSerum albumin/0.441
4a81DXCMajor pollen allergen Bet v 1-A/0.441
4b1fKRHGlutamate racemase/0.441
4flpJQ1Bromodomain testis-specific protein/0.441
4g7gVFVLanosterol 14-alpha-demethylase/0.441
4uxq0LIFibroblast growth factor receptor 42.7.10.10.441
5ab7MLCNonspecific lipid-transfer protein, putative/0.441
5k2dZMAAdenosine receptor A2a/0.441
1hpzAAPGag-Pol polyprotein2.7.7.490.440
1o1vTCHGastrotropin/0.440
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
1sr7MOFProgesterone receptor/0.440
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
2d29FADAcyl-CoA dehydrogenase/0.440
2e08SAHDiphthine synthase/0.440
2gvcFADThiol-specific monooxygenase1.14.130.440
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.440
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.440
2q153MRBeta-secretase 13.4.23.460.440
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.440
2zlcVDXVitamin D3 receptor/0.440
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3m8p65BGag-Pol polyprotein2.7.7.490.440
3nga3NGCasein kinase II subunit alpha2.7.11.10.440
3nksACJProtoporphyrinogen oxidase1.3.3.40.440
3u8dU8DPhospholipase A2, membrane associated/0.440
3uawADNPurine nucleoside phosphorylase DeoD-type/0.440
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3vg9ZMAAdenosine receptor A2a/0.440
3vt45YIVitamin D3 receptor/0.440
3zkuHCVIsopenicillin N synthase1.21.3.10.440
4a95NHWGlycylpeptide N-tetradecanoyltransferase/0.440
4bb3KKAIsopenicillin N synthase1.21.3.10.440
4boeCLRJapanin/0.440
4cd2FOLDihydrofolate reductase1.5.1.30.440
4dfrMTXDihydrofolate reductase1.5.1.30.440
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.440
4ugaQ05Nitric oxide synthase oxygenase1.14.13.1650.440
5ab6CAANonspecific lipid-transfer protein, putative/0.440