scPDB - Distribution of Binding site Similarity values of 3cth entry / Site 1

PDB ID	HET	Uniprot Name	EC Number
3cth	319	Hepatocyte growth factor receptor	2.7.10.1

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3cth	319	Hepatocyte growth factor receptor	2.7.10.1	1.000
3ctj	320	Hepatocyte growth factor receptor	2.7.10.1	0.640
3f82	353	Hepatocyte growth factor receptor	2.7.10.1	0.570
5bvw	1N1	Epithelial discoidin domain-containing receptor 1	2.7.10.1	0.568
3oez	STI	Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	0.566
3tub	FPU	Tyrosine-protein kinase SYK	2.7.10.2	0.562
3ce3	1FN	Hepatocyte growth factor receptor	2.7.10.1	0.554
4equ	G6I	Serine/threonine-protein kinase 10	2.7.11.1	0.540
4fny	I3K	ALK tyrosine kinase receptor	2.7.10.1	0.531
2rl5	2RL	Vascular endothelial growth factor receptor 2	2.7.10.1	0.528
4tyj	0LI	Fibroblast growth factor receptor 4	2.7.10.1	0.527
4eev	L1X	Hepatocyte growth factor receptor	2.7.10.1	0.526
4i6f	1C7	Serine/threonine-protein kinase PLK2	2.7.11.21	0.526
4a4x	JUP	Serine/threonine-protein kinase Nek2	2.7.11.1	0.524
4i6h	1C8	Serine/threonine-protein kinase PLK2	2.7.11.21	0.524
1e92	HBI	Pteridine reductase 1	1.5.1.33	0.523
1q5d	EPB	Epothilone C/D epoxidase	1.14	0.523
2xk4	OL2	Serine/threonine-protein kinase Nek2	2.7.11.1	0.522
2xkc	4VQ	Serine/threonine-protein kinase Nek2	2.7.11.1	0.521
3h4v	DVP	Pteridine reductase 1	1.5.1.33	0.521
1pkf	EPD	Epothilone C/D epoxidase	1.14	0.520
3c1x	CKK	Hepatocyte growth factor receptor	2.7.10.1	0.519
2oh4	GIG	Vascular endothelial growth factor receptor 2	2.7.10.1	0.513
2z2w	770	Wee1-like protein kinase	2.7.10.2	0.511
3be2	RAJ	Vascular endothelial growth factor receptor 2	2.7.10.1	0.509
2bfa	CB3	Pteridine reductase 1	1.5.1.33	0.507
4v01	0LI	Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b	/	0.506
2jc6	QPP	Calcium/calmodulin-dependent protein kinase type 1D	2.7.11.17	0.505
2pl0	STI	Tyrosine-protein kinase Lck	2.7.10.2	0.504
2xkd	T3M	Serine/threonine-protein kinase Nek2	2.7.11.1	0.501
3vw8	DF6	Hepatocyte growth factor receptor	2.7.10.1	0.501
4afe	GGY	Serine/threonine-protein kinase Nek2	2.7.11.1	0.501
2ofv	242	Tyrosine-protein kinase Lck	2.7.10.2	0.500
2og8	1N8	Tyrosine-protein kinase Lck	2.7.10.2	0.500
5iu4	ZMA	Adenosine receptor A2a	/	0.500
1bk0	ACV	Isopenicillin N synthase	1.21.3.1	0.498
2bfp	H4B	Pteridine reductase 1	1.5.1.33	0.498
4b12	C23	Glycylpeptide N-tetradecanoyltransferase	/	0.498
4at4	T6E	BDNF/NT-3 growth factors receptor	2.7.10.1	0.497
4h1j	0YH	Protein-tyrosine kinase 2-beta	2.7.10.2	0.497
3htj	ET	EbrA repressor	/	0.496
4elb	34R	Dihydrofolate reductase	/	0.496
1hb1	OCV	Isopenicillin N synthase	1.21.3.1	0.495
2xnp	WCX	Serine/threonine-protein kinase Nek2	2.7.11.1	0.495
2osc	MUH	Angiopoietin-1 receptor	2.7.10.1	0.494
5iu8	6DZ	Adenosine receptor A2a	/	0.494
3lfe	Z84	Mitogen-activated protein kinase 14	/	0.493
3eta	351	Insulin receptor	2.7.10.1	0.492
2e99	B08	Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	2.5.1.31	0.491
2i0e	PDS	Protein kinase C beta type	2.7.11.13	0.491
2yac	937	Serine/threonine-protein kinase PLK1	2.7.11.21	0.491
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.491
4qrc	0LI	Fibroblast growth factor receptor 4	2.7.10.1	0.491
1uzw	CDH	Isopenicillin N synthase	1.21.3.1	0.490
4jib	1L6	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.490
4uxq	0LI	Fibroblast growth factor receptor 4	2.7.10.1	0.490
2owb	626	Serine/threonine-protein kinase PLK1	2.7.11.21	0.489
4a4l	939	Serine/threonine-protein kinase PLK1	2.7.11.21	0.489
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.488
3lfc	Z86	Mitogen-activated protein kinase 14	/	0.487
4hvs	647	Mast/stem cell growth factor receptor Kit	2.7.10.1	0.486
1hb3	SCV	Isopenicillin N synthase	1.21.3.1	0.485
2xke	WI2	Serine/threonine-protein kinase Nek2	2.7.11.1	0.485
3dko	IHZ	Ephrin type-A receptor 7	2.7.10.1	0.485
3q2m	CKI	Spectinomycin phosphotransferase	/	0.484
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.483
2gqg	1N1	Tyrosine-protein kinase ABL1	2.7.10.2	0.483
4j52	1J3	Serine/threonine-protein kinase PLK1	2.7.11.21	0.483
1uwh	BAX	Serine/threonine-protein kinase B-raf	2.7.11.1	0.482
1w06	W05	Isopenicillin N synthase	1.21.3.1	0.482
2xk3	XK3	Serine/threonine-protein kinase Nek2	2.7.11.1	0.482
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.482
4few	PP2	Aminoglycoside 3'-phosphotransferase AphA1-IAB	/	0.482
4k9y	K9Y	Focal adhesion kinase 1	2.7.10.2	0.482
3e5a	VX6	Aurora kinase A	2.7.11.1	0.481
3zoi	M2W	Isopenicillin N synthase	1.21.3.1	0.481
3uza	T4G	Adenosine receptor A2a	/	0.481
1uho	VDN	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.480
3njo	PYV	Abscisic acid receptor PYR1	/	0.480
3up3	XCA	aceDAF-12	/	0.480
4kao	KAO	Focal adhesion kinase 1	2.7.10.2	0.480
4twn	B96	Ephrin type-A receptor 3	2.7.10.1	0.480
5k2b	ZMA	Adenosine receptor A2a	/	0.480
2bfm	TOP	Pteridine reductase 1	1.5.1.33	0.479
3aba	FLI	Cytochrome P450	/	0.479
3bi6	396	Wee1-like protein kinase	2.7.10.2	0.479
3sru	Q26	Dihydrofolate reductase	1.5.1.3	0.479
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.479
5g53	NEC	Adenosine receptor A2a	/	0.479
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.478
1e7w	MTX	Pteridine reductase 1	1.5.1.33	0.478
2e98	B29	Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	2.5.1.31	0.478
2y6f	M9F	Isopenicillin N synthase	1.21.3.1	0.478
3eml	ZMA	Adenosine receptor A2a	/	0.478
1exa	394	Retinoic acid receptor gamma	/	0.477
2b04	CHO	Phospholipase A2, major isoenzyme	3.1.1.4	0.477
2ivi	ACW	Isopenicillin N synthase	1.21.3.1	0.477
3iw8	HIZ	Mitogen-activated protein kinase 14	/	0.477
5k2c	ZMA	Adenosine receptor A2a	/	0.477
2e48	FAD	D-amino-acid oxidase	1.4.3.3	0.476
2lbd	REA	Retinoic acid receptor gamma	/	0.476
4j6d	TES	Cytochrome P450 monooxygenase	/	0.476
5k2a	ZMA	Adenosine receptor A2a	/	0.476
2a19	ANP	Interferon-induced, double-stranded RNA-activated protein kinase	2.7.11.1	0.475
2wo7	ASV	Isopenicillin N synthase	1.21.3.1	0.475
3vt7	VDX	Vitamin D3 receptor	/	0.475
4af3	VX6	Aurora kinase B	2.7.11.1	0.475
1dis	BDM	Dihydrofolate reductase	1.5.1.3	0.474
1fgi	SU1	Fibroblast growth factor receptor 1	/	0.474
1p33	MTX	Pteridine reductase 1	1.5.1.33	0.474
1y60	H4M	5,6,7,8-tetrahydromethanopterin hydro-lyase	4.2.1.147	0.474
2jb4	A14	Isopenicillin N synthase	1.21.3.1	0.474
3p9t	TCL	Repressor	/	0.474
4hni	16W	Casein kinase I isoform epsilon	2.7.11.1	0.474
1fcx	184	Retinoic acid receptor gamma	/	0.473
1kzj	CB3	Thymidylate synthase	/	0.473
2ewa	SB2	Mitogen-activated protein kinase 14	/	0.473
2uxp	CLM	HTH-type transcriptional regulator TtgR	/	0.473
4b14	4XB	Glycylpeptide N-tetradecanoyltransferase	/	0.473
4bkj	STI	Epithelial discoidin domain-containing receptor 1	2.7.10.1	0.473
4jau	ADP	Sensor histidine kinase	/	0.473
2xk6	EQH	Serine/threonine-protein kinase Nek2	2.7.11.1	0.472
3biz	61E	Wee1-like protein kinase	2.7.10.2	0.472
4ddl	0JQ	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.472
4fgh	0U6	Dihydrofolate reductase	1.5.1.3	0.472
1rgs	CMP	cAMP-dependent protein kinase type I-alpha regulatory subunit	/	0.471
2bf7	HBI	Pteridine reductase 1	1.5.1.33	0.471
2wpx	ACO	Orf14	/	0.471
2y98	MIV	Mycinamicin IV hydroxylase/epoxidase	/	0.471
2x9v	TMQ	Pteridine reductase	/	0.470
2ydo	ADN	Adenosine receptor A2a	/	0.470
3prf	FP3	Serine/threonine-protein kinase B-raf	2.7.11.1	0.470
4bbh	YBN	Glycylpeptide N-tetradecanoyltransferase	/	0.470
4j53	1J4	Serine/threonine-protein kinase PLK1	2.7.11.21	0.470
1ia3	TQ5	Dihydrofolate reductase	1.5.1.3	0.469
2rku	R78	Serine/threonine-protein kinase PLK1	2.7.11.21	0.469
2yne	YNE	Glycylpeptide N-tetradecanoyltransferase	/	0.469
4b8m	VX6	Aurora kinase B-A	2.7.11.1	0.469
4ixc	1JD	Glucokinase	2.7.1.2	0.469
3rfm	CFF	Adenosine receptor A2a	/	0.469
1osv	CHC	Bile acid receptor	/	0.468
2ham	C33	Vitamin D3 receptor	/	0.468
3a1l	2CC	Cytochrome P450	/	0.468
3fzt	4JZ	Protein-tyrosine kinase 2-beta	2.7.10.2	0.468
3qri	919	Tyrosine-protein kinase ABL1	2.7.10.2	0.468
4cry	ACO	PanD regulatory factor	/	0.468
4j6c	STR	Cytochrome P450 monooxygenase	/	0.468
5iub	CLR	Adenosine receptor A2a	/	0.468
5uvi	ZMA	Adenosine receptor A2a	/	0.468
1qiq	ACC	Isopenicillin N synthase	1.21.3.1	0.467
2xk7	30E	Serine/threonine-protein kinase Nek2	2.7.11.1	0.467
3l0l	HC3	Nuclear receptor ROR-gamma	/	0.467
3qm4	PN0	Cytochrome P450 2D6	/	0.467
3zku	HCV	Isopenicillin N synthase	1.21.3.1	0.467
4a4o	664	Serine/threonine-protein kinase PLK1	2.7.11.21	0.467
4b6l	9ZP	Serine/threonine-protein kinase PLK3	2.7.11.21	0.467
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.466
2gvc	FAD	Thiol-specific monooxygenase	1.14.13	0.466
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.466
3vev	0H4	Glucokinase	2.7.1.2	0.466
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.466
4r20	AER	Cytochrome P450 family 17 polypeptide 2	/	0.466
2xnn	430	Serine/threonine-protein kinase Nek2	2.7.11.1	0.465
2ydv	NEC	Adenosine receptor A2a	/	0.465
3v94	WYQ	Phosphodiesterase	/	0.465
4cjx	9L9	C-1-tetrahydrofolate synthase, cytoplasmic, putative	/	0.465
4gqk	ADP	Actin cross-linking toxin VgrG1	/	0.465
5cc9	DDF	Dihydrofolate reductase	1.5.1.3	0.465
1ia4	TQ6	Dihydrofolate reductase	1.5.1.3	0.464
2uag	UMA	UDP-N-acetylmuramoylalanine--D-glutamate ligase	6.3.2.9	0.464
2vcm	M11	Isopenicillin N synthase	1.21.3.1	0.464
4iar	ERM	5-hydroxytryptamine receptor 1B	/	0.464
1o5r	FR9	Adenosine deaminase	3.5.4.4	0.463
2g7y	MO9	Cathepsin S	3.4.22.27	0.463
2hm9	TRR	Dihydrofolate reductase	1.5.1.3	0.463
3byz	H11	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.463
3cr0	809	Wee1-like protein kinase	2.7.10.2	0.463
3vf6	0H6	Glucokinase	2.7.1.2	0.463
3vt9	YI4	Vitamin D3 receptor	/	0.463
4eiy	ZMA	Adenosine receptor A2a	/	0.463
5iua	6DX	Adenosine receptor A2a	/	0.463
1upw	444	Oxysterols receptor LXR-beta	/	0.462
1v7a	FRC	Adenosine deaminase	3.5.4.4	0.462
2ovv	PFH	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.462
4c2w	ANP	Aurora kinase B-A	2.7.11.1	0.462
1h36	R88	Squalene--hopene cyclase	4.2.1.129	0.461
2hog	710	Serine/threonine-protein kinase Chk1	2.7.11.1	0.461
2j9l	ATP	H(+)/Cl(-) exchange transporter 5	/	0.461
2vbd	V10	Isopenicillin N synthase	1.21.3.1	0.461
2wey	EV1	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.461
3jwc	EKB	Dihydrofolate reductase	/	0.461
4nb6	444	Nuclear receptor ROR-gamma	/	0.461
1fdw	EST	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.460
2bjs	ACV	Isopenicillin N synthase	1.21.3.1	0.460
2xkf	BX1	Serine/threonine-protein kinase Nek2	2.7.11.1	0.460
2xnm	WGZ	Serine/threonine-protein kinase Nek2	2.7.11.1	0.460
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.460
4fk3	325	Serine/threonine-protein kinase B-raf	2.7.11.1	0.460
5k2d	ZMA	Adenosine receptor A2a	/	0.460
1mkd	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.459
2qhx	FE1	Pteridine reductase 1	1.5.1.33	0.459
2wqo	VGK	Serine/threonine-protein kinase Nek2	2.7.11.1	0.459
3gyu	DL7	Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily	/	0.459
3kpz	ZNE	Vitamin D3 receptor	/	0.459
3nax	MP7	3-phosphoinositide-dependent protein kinase 1	2.7.11.1	0.459
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.459
5jtb	ZMA	Adenosine receptor A2a	/	0.459
1cqp	803	Integrin alpha-L	/	0.458
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.458
1tbb	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.458
1tw2	ERT	Carminomycin 4-O-methyltransferase DnrK	2.1.1.292	0.458
1x8b	824	Wee1-like protein kinase	2.7.10.2	0.458
1zg3	2HI	Isoflavone 4'-O-methyltransferase	/	0.458
2bak	AQZ	Mitogen-activated protein kinase 14	/	0.458
2gpv	OHT	Estrogen-related receptor gamma	/	0.458
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.458
3g0e	B49	Mast/stem cell growth factor receptor Kit	2.7.10.1	0.458
3tda	PN0	Cytochrome P450 2D6	/	0.458
4a9y	AQZ	Mitogen-activated protein kinase 14	/	0.458
4l5b	1UX	Deoxycytidine kinase	2.7.1.74	0.458
4wdb	2AM	2',3'-cyclic-nucleotide 3'-phosphodiesterase	3.1.4.37	0.458
5d1b	TSN	Histone deacetylase 8	3.5.1.98	0.458
1mcz	RMN	Benzoylformate decarboxylase	4.1.1.7	0.457
1ne6	SP1	cAMP-dependent protein kinase type I-alpha regulatory subunit	/	0.457
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.457
1pke	2FD	Purine nucleoside phosphorylase DeoD-type	/	0.457
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.457
2ij7	TPF	Mycocyclosin synthase	1.14.21.9	0.457
2ow3	BIM	Glycogen synthase kinase-3 beta	2.7.11.26	0.457
1syn	F89	Thymidylate synthase	/	0.456
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.456
2y60	M8F	Isopenicillin N synthase	1.21.3.1	0.456
3q44	D50	M1 family aminopeptidase	3.4.11	0.456
3u8h	BHP	Phospholipase A2, membrane associated	/	0.456
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.456
4jbt	ASD	Cytochrome P450 monooxygenase	/	0.456
4jx1	CAH	Camphor 5-monooxygenase	1.14.15.1	0.456
4qa0	SHH	Histone deacetylase 8	3.5.1.98	0.456
1p8d	CO1	Oxysterols receptor LXR-beta	/	0.455
2xk8	5R1	Serine/threonine-protein kinase Nek2	2.7.11.1	0.455
3iej	599	Cathepsin S	3.4.22.27	0.455
3pqb	VGP	Putative oxidoreductase	/	0.455
3qv1	NAD	Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic	1.2.1.13	0.455
4ckr	DI1	Epithelial discoidin domain-containing receptor 1	2.7.10.1	0.455
4i1n	FOL	Dihydrofolate reductase	1.5.1.3	0.455
4k4e	K4E	Tankyrase-1	2.4.2.30	0.455
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.454
1u0h	ONM	Adenylate cyclase type 2	/	0.454
1u0h	ONM	Adenylate cyclase type 5	/	0.454
2fb8	215	Serine/threonine-protein kinase B-raf	2.7.11.1	0.454
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.454
3c0g	3AM	Peripheral plasma membrane protein CASK	2.7.11.1	0.454
3cqe	P91	Wee1-like protein kinase	2.7.10.2	0.454
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.454
3s41	S41	Glucokinase	2.7.1.2	0.454
3t8x	T8X	T-cell surface glycoprotein CD1b	/	0.454
3uvv	REA	Retinoic acid receptor RXR-alpha	/	0.454
3w2c	N15	Aurora kinase A	2.7.11.1	0.454
4at3	LTI	BDNF/NT-3 growth factors receptor	2.7.10.1	0.454
4bb5	HD2	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.454
5ckw	ANP	Uncharacterized protein	/	0.454
1ao8	MTX	Dihydrofolate reductase	1.5.1.3	0.453
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.453
2h44	7CA	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.453
3bqd	DAY	Glucocorticoid receptor	/	0.453
3bzu	A21	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.453
3jyn	NDP	Quinone oxidoreductase	/	0.453
4bii	PYW	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.453
4neu	Q1A	Receptor-interacting serine/threonine-protein kinase 1	2.7.11.1	0.453
4u9y	COA	Alpha-tubulin N-acetyltransferase 1	/	0.453
1efa	NPF	Lactose operon repressor	/	0.452
1o6q	R17	Squalene--hopene cyclase	4.2.1.129	0.452
1o6r	R19	Squalene--hopene cyclase	4.2.1.129	0.452
1r0e	DFN	Glycogen synthase kinase-3 beta	2.7.11.26	0.452
1soj	IBM	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	3.1.4.17	0.452
2p1u	4TN	Retinoic acid receptor RXR-alpha	/	0.452
2w5b	AGS	Serine/threonine-protein kinase Nek2	2.7.11.1	0.452
2wsa	646	Glycylpeptide N-tetradecanoyltransferase	/	0.452
3djl	FAD	Putative acyl-CoA dehydrogenase AidB	1.3.99	0.452
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.452
3g49	3G4	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.452
3oct	1N1	Tyrosine-protein kinase BTK	2.7.10.2	0.452
3vg9	ZMA	Adenosine receptor A2a	/	0.452
3vwd	ACO	Alpha-tubulin N-acetyltransferase 1	/	0.452
4b11	7I1	Glycylpeptide N-tetradecanoyltransferase	/	0.452
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.452
4gs4	ACO	Alpha-tubulin N-acetyltransferase 1	/	0.452
5akk	1P8	Bifunctional epoxide hydrolase 2	3.1.3.76	0.452
1ly4	COQ	Dihydrofolate reductase	1.5.1.3	0.451
2in6	839	Wee1-like protein kinase	2.7.10.2	0.451
2rjp	886	A disintegrin and metalloproteinase with thrombospondin motifs 4	3.4.24.82	0.451
2w3v	TOP	Dihydrofolate reductase	/	0.451
3d74	NBB	Pheromone-binding protein ASP1	/	0.451
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.451
3n65	XFJ	Nitric oxide synthase, brain	1.14.13.39	0.451
3vo3	0KF	Vascular endothelial growth factor receptor 2	2.7.10.1	0.451
4a9m	P9M	Bromodomain-containing protein 2	/	0.451
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.451
5d7q	4I5	NAD-dependent protein deacetylase sirtuin-2	3.5.1	0.451
3qak	UKA	Adenosine receptor A2a	/	0.451
1w83	L11	Mitogen-activated protein kinase 14	/	0.450
1xf0	ASD	Aldo-keto reductase family 1 member C3	/	0.450
2y0j	AXC	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.450
2yhu	WHF	Pteridine reductase	/	0.450
3zei	AWH	O-acetylserine sulfhydrylase	/	0.450
4ajw	VWN	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	2.7.1.153	0.450
4y9l	FAD	Acyl-CoA dehydrogenase family member 11	/	0.450
4uhr	NGI	Adenosine receptor A2a	/	0.450
3rey	XAC	Adenosine receptor A2a	/	0.450
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.449
1fd0	254	Retinoic acid receptor gamma	/	0.449
1odn	APV	Isopenicillin N synthase	1.21.3.1	0.449
1s7g	NAD	NAD-dependent protein deacylase 2	/	0.449
2bro	DF2	Serine/threonine-protein kinase Chk1	2.7.11.1	0.449
2yg4	FAD	Putrescine oxidase	/	0.449
3dyq	PCG	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.449
3f0a	ACO	Spermidine N(1)-acetyltransferase	/	0.449
3g4i	D71	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.449
3sni	546	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.449
3up0	D7S	aceDAF-12	/	0.449
4a99	MIY	TetX family tetracycline inactivation enzyme	/	0.449
4ach	KDI	Glycogen synthase kinase-3 beta	2.7.11.26	0.449
4b5o	ACO	Alpha-tubulin N-acetyltransferase 1	/	0.449
4ia1	BIV	Vitamin D3 receptor A	/	0.449
4j6b	PLO	Cytochrome P450 monooxygenase	/	0.449
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.449
5hbr	COA	Acyl-CoA synthetase (NDP forming)	/	0.449
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.448
1nqu	RDL	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.448
1olm	VTQ	SEC14-like protein 2	/	0.448
1xds	DRA	Aclacinomycin 10-hydroxylase RdmB	4.1.1	0.448
2b36	5PP	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.448
2fon	FAD	Acyl-coenzyme A oxidase	/	0.448
2g2h	P16	Tyrosine-protein kinase ABL1	2.7.10.2	0.448
3gcq	1BU	Mitogen-activated protein kinase 14	/	0.448
3hv3	R49	Mitogen-activated protein kinase 14	/	0.448
3pm9	FAD	Putative oxidoreductase	/	0.448
3zsg	T75	Mitogen-activated protein kinase 14	/	0.448
4alh	A9P	Bromodomain-containing protein 2	/	0.448
4bgg	844	Activin receptor type-1	2.7.11.30	0.448
4f1s	F1S	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.448
4gmy	0X5	Tyrosine-protein kinase JAK2	/	0.448
4j4v	SVR	Nucleocapsid protein	/	0.448
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.448
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.448
4qml	ANP	Serine/threonine-protein kinase 24	2.7.11.1	0.448
1fcy	564	Retinoic acid receptor gamma	/	0.447
1nce	CB3	Thymidylate synthase	/	0.447
1sd2	MTH	S-methyl-5'-thioadenosine phosphorylase	/	0.447
2g78	REA	Cellular retinoic acid-binding protein 2	/	0.447
2j4z	626	Aurora kinase A	2.7.11.1	0.447
2ph5	NAD	Homospermidine synthase	/	0.447
3bfa	9OD	Odorant binding protein ASP1	/	0.447
3cv9	VDX	Vitamin D3 dihydroxylase	/	0.447
3ft8	MOJ	Heat shock protein HSP 90-alpha	/	0.447
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.447
3itu	IBM	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.447
3kyt	HC2	Nuclear receptor ROR-gamma	/	0.447
3nxy	D2H	Dihydrofolate reductase	1.5.1.3	0.447
3vjc	ZGA	Squalene synthase	2.5.1.21	0.447
4dm6	TTB	Retinoic acid receptor beta	/	0.447
4gki	0JN	Aminoglycoside 3'-phosphotransferase AphA1-IAB	/	0.447
4h1e	10J	Beta-secretase 1	3.4.23.46	0.447
4heu	15J	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.447
4htx	19F	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.447
4jlj	1NM	Deoxycytidine kinase	2.7.1.74	0.447
5gcn	COA	HAT A1	/	0.447
5hbs	RTL	Retinol-binding protein 1	/	0.447
3pwh	ZMA	Adenosine receptor A2a	/	0.447
1jom	FFO	Dihydrofolate reductase	1.5.1.3	0.446
1ndz	FR5	Adenosine deaminase	3.5.4.4	0.446
1oc1	ASV	Isopenicillin N synthase	1.21.3.1	0.446
1uy8	PU5	Heat shock protein HSP 90-alpha	/	0.446
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.446
2xno	ED8	Serine/threonine-protein kinase Nek2	2.7.11.1	0.446
3g7j	GTX	Glutathione transferase GST1-4	/	0.446
3sqy	Q11	Dihydrofolate reductase	1.5.1.3	0.446
3wsb	RWZ	Farnesyltransferase, putative	/	0.446
3zrm	ZRM	Glycogen synthase kinase-3 beta	2.7.11.26	0.446
4dbw	511	Aldo-keto reductase family 1 member C3	/	0.446
4k18	1OB	Serine/threonine-protein kinase pim-1	2.7.11.1	0.446
1buc	FAD	Acyl-CoA dehydrogenase, short-chain specific	1.3.8.1	0.445
1h35	R01	Squalene--hopene cyclase	4.2.1.129	0.445
1obn	ASV	Isopenicillin N synthase	1.21.3.1	0.445
1xom	CIO	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.445
1yho	TRR	Dihydrofolate reductase	1.5.1.3	0.445
2j2i	LY4	Serine/threonine-protein kinase pim-1	2.7.11.1	0.445
2ji9	ADP	Oxalyl-CoA decarboxylase	4.1.1.8	0.445
3dh7	FMN	Isopentenyl-diphosphate delta-isomerase	/	0.445
3uzw	NAP	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.445
3wd9	QPC	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.445
4fcd	0T6	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.445
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.445
4g31	0WH	Eukaryotic translation initiation factor 2-alpha kinase 3	2.7.11.1	0.445
4iah	1DX	Alr2278 protein	/	0.445
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.445
1dli	UDX	UDP-glucose 6-dehydrogenase	/	0.444
1iyz	NDP	Probable quinone oxidoreductase	/	0.444
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.444
1y2c	3DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.444
2hcd	BIV	Vitamin D3 receptor A	/	0.444
3lu8	IQX	Serum albumin	/	0.444
3tk3	CPZ	Cytochrome P450 2B4	1.14.14.1	0.444
3vt4	5YI	Vitamin D3 receptor	/	0.444
4elb	34S	Dihydrofolate reductase	/	0.444
4elf	35I	Dihydrofolate reductase	/	0.444
4g1n	NZT	Pyruvate kinase PKM	2.7.1.40	0.444
4g2y	NI5	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.444
4u9z	COA	Alpha-tubulin N-acetyltransferase 1	/	0.444
5h8t	RTL	Retinol-binding protein 1	/	0.444
5irn	ADP	Nucleotide binding oligomerization domain containing 2	/	0.444
1bzf	TMQ	Dihydrofolate reductase	1.5.1.3	0.443
1fdu	EST	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.443
1zdw	FLV	Prenyltransferase	/	0.443
2bkt	RPF	Renin	3.4.23.15	0.443
2bu9	HFV	Isopenicillin N synthase	1.21.3.1	0.443
2io6	330	Wee1-like protein kinase	2.7.10.2	0.443
2w5a	ADP	Serine/threonine-protein kinase Nek2	2.7.11.1	0.443
2wi7	2KL	Heat shock protein HSP 90-alpha	/	0.443
3amb	VX6	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.443
3ews	ADP	ATP-dependent RNA helicase DDX19B	3.6.4.13	0.443
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.443
3p6n	DSO	Camphor 5-monooxygenase	1.14.15.1	0.443
3p6o	ETG	Camphor 5-monooxygenase	1.14.15.1	0.443
3r0t	FU9	Casein kinase II subunit alpha	2.7.11.1	0.443
4a28	ADP	Kinesin-like protein KIF11	/	0.443
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.443
4kln	AGS	Transitional endoplasmic reticulum ATPase	3.6.4.6	0.443
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.443
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.442
1c7o	PPG	Hemolysin	/	0.442
1fds	EST	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.442
1fp1	HCC	Isoliquiritigenin 2'-O-methyltransferase	/	0.442
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.442
1l2j	ETC	Estrogen receptor beta	/	0.442
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.442
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.442
1qxl	FR8	Adenosine deaminase	3.5.4.4	0.442
1szm	BI4	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.442
2a4n	COA	Aac(6')-Ii protein	/	0.442
2rab	NAD	Glutathione amide reductase	/	0.442
3bmc	FOL	Pteridine reductase	/	0.442
3hfb	ML4	Tryptophan 5-hydroxylase 1	1.14.16.4	0.442
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.442
3njo	P2M	Abscisic acid receptor PYR1	/	0.442
3nx4	NAP	Putative oxidoreductase	/	0.442
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.442
3srw	Q27	Dihydrofolate reductase	1.5.1.3	0.442
3vtd	TKD	Vitamin D3 receptor	/	0.442
3zrr	PXG	Serine-pyruvate aminotransferase (AgxT)	/	0.442
4gg5	0J3	Hepatocyte growth factor receptor	2.7.10.1	0.442
4ia2	BIV	Vitamin D3 receptor A	/	0.442
4jq4	IMN	Aldo-keto reductase family 1 member C2	/	0.442
4lv8	ADP	Rhoptry protein 5 C	/	0.442
4wbo	ANW	Rhodopsin kinase	/	0.442
5ab7	MLC	Nonspecific lipid-transfer protein, putative	/	0.442
5dp2	NAP	CurF	/	0.442
5hwq	CAA	Hydroxymethylglutaryl-CoA synthase	/	0.442
1hsk	FAD	UDP-N-acetylenolpyruvoylglucosamine reductase	/	0.441
1ppj	SMA	Cytochrome b	/	0.441
1r00	SAH	Aclacinomycin 10-hydroxylase RdmB	4.1.1	0.441
1yc2	NAD	NAD-dependent protein deacylase 2	/	0.441
2has	C3O	Vitamin D3 receptor	/	0.441
2pnu	ENM	Androgen receptor	/	0.441
2psw	COA	N-alpha-acetyltransferase 50	/	0.441
2pul	ACP	Methylthioribose kinase	2.7.1.100	0.441
2y37	A54	Nitric oxide synthase, inducible	1.14.13.39	0.441
2zru	FMN	Isopentenyl-diphosphate delta-isomerase	/	0.441
3hf6	LX0	Tryptophan 5-hydroxylase 1	1.14.16.4	0.441
3hf8	ML0	Tryptophan 5-hydroxylase 1	1.14.16.4	0.441
3hxe	BD8	Geranylgeranyl transferase type-2 subunit beta	2.5.1.60	0.441
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.441
3l8s	BFF	Mitogen-activated protein kinase 14	/	0.441
3ldg	SAH	Uncharacterized protein	/	0.441
3nga	3NG	Casein kinase II subunit alpha	2.7.11.1	0.441
3qly	55V	Uncharacterized protein	/	0.441
3slk	NDP	Polyketide synthase extender module 2	/	0.441
3thr	C2F	Glycine N-methyltransferase	2.1.1.20	0.441
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.441
4b2g	V1N	Uncharacterized protein	/	0.441
4bb6	HD1	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.441
4bfp	SWY	Tankyrase-2	2.4.2.30	0.441
4dqu	NAI	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.441
4g48	PZB	Mycocyclosin synthase	1.14.21.9	0.441
4gi2	NAP	Crotonyl-CoA carboxylase/reductase	/	0.441
4iaq	2GM	5-hydroxytryptamine receptor 1B	/	0.441
4py6	R78	Bromodomain protein, putative	/	0.441
4qa2	SHH	Histone deacetylase 8	3.5.1.98	0.441
4z9r	NAD	Omega-3 polyunsaturated fatty acid synthase subunit PfaD	/	0.441
5jy1	NAD	Putative short-chain dehydrogenase/reductase	/	0.441
1dgf	NDP	Catalase	1.11.1.6	0.440
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.440
1q6s	214	Tyrosine-protein phosphatase non-receptor type 1	3.1.3.48	0.440
1qjf	ACS	Isopenicillin N synthase	1.21.3.1	0.440
1rkh	VD2	Vitamin D3 receptor	/	0.440
1uhl	MEI	Retinoic acid receptor RXR-beta	/	0.440
1xu7	CPS	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.440
2b37	8PS	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.440
2hb7	O1C	Vitamin D3 receptor	/	0.440
2jkc	FAD	Flavin-dependent tryptophan halogenase PrnA	1.14.19.9	0.440
3arv	SAU	Chitinase A	/	0.440
3dhe	AND	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.440
3du8	553	Glycogen synthase kinase-3 beta	2.7.11.26	0.440
3fra	I2H	Dihydrofolate reductase	1.5.1.3	0.440
3gb4	D3M	DdmC	/	0.440
3sn7	540	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.440
3srr	Q20	Dihydrofolate reductase	1.5.1.3	0.440
3vt6	5YI	Vitamin D3 receptor	/	0.440
3wi2	P98	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.440
3zk6	H1I	Bcl-2-like protein 1	/	0.440
4ajd	F04	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.440
4anu	EM7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.440
4cs0	ACO	PanD regulatory factor	/	0.440
4ej1	FOL	Dihydrofolate reductase	1.5.1.3	0.440
4fex	0TO	Aminoglycoside 3'-phosphotransferase AphA1-IAB	/	0.440
4fjz	4FJ	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.440
4hf4	15H	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.440
4rqu	NAD	Alcohol dehydrogenase class-P	/	0.440
4ubs	DIF	Pentalenic acid synthase	1.14.15.11	0.440
5doz	NDP	JamJ	/	0.440