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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3cscACOCitrate synthase, mitochondrial2.3.3.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3cscACOCitrate synthase, mitochondrial2.3.3.11.000
1cscCMCCitrate synthase, mitochondrial2.3.3.10.771
6ctsCICCitrate synthase, mitochondrial2.3.3.10.694
5ctsCMCCitrate synthase, mitochondrial2.3.3.10.616
2r26CMCCitrate synthase2.3.3.160.538
2h12CMXCitrate synthase/0.536
2r9eSDXCitrate synthase2.3.3.160.522
2ctsCOACitrate synthase, mitochondrial2.3.3.10.495
1aj8COACitrate synthase/0.494
1ixeCOACitrate synthase/0.476