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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3cs9NILTyrosine-protein kinase ABL12.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3cs9NILTyrosine-protein kinase ABL12.7.10.21.000
3p7bP7BMitogen-activated protein kinase 14/0.518
3p79P79Mitogen-activated protein kinase 14/0.495
3p5kP5KMitogen-activated protein kinase 14/0.494
3hv71AUMitogen-activated protein kinase 14/0.491
3nnxEDDMitogen-activated protein kinase 14/0.487
3ugc046Tyrosine-protein kinase JAK2/0.483
3g7jGTXGlutathione transferase GST1-4/0.481
3gcuR48Mitogen-activated protein kinase 14/0.481
2e2b406Tyrosine-protein kinase ABL12.7.10.20.474
2yisYISMitogen-activated protein kinase 14/0.468
3npcB96Mitogen-activated protein kinase 92.7.11.240.467
3nnuEDBMitogen-activated protein kinase 14/0.465
1wbsLI2Mitogen-activated protein kinase 14/0.462
1mc5AHEAlcohol dehydrogenase class-31.1.1.10.461
4u0i0LIMast/stem cell growth factor receptor Kit2.7.10.10.460
3nnwEDDMitogen-activated protein kinase 14/0.458
3vhe42QVascular endothelial growth factor receptor 22.7.10.10.457
3wzeBAXVascular endothelial growth factor receptor 22.7.10.10.455
2yiwYIWMitogen-activated protein kinase 14/0.454
3d83GK6Mitogen-activated protein kinase 14/0.454
3hv4L51Mitogen-activated protein kinase 14/0.450
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.449
1wbvLI3Mitogen-activated protein kinase 14/0.447
1kv2B96Mitogen-activated protein kinase 14/0.444
1zotEMABifunctional hemolysin/adenylate cyclase4.6.1.10.443
1wbnL09Mitogen-activated protein kinase 14/0.442
1wbtWBTMitogen-activated protein kinase 14/0.441
3o8uBMUMitogen-activated protein kinase 14/0.440
4ej1FOLDihydrofolate reductase1.5.1.30.440
4o2z046Mitogen-activated protein kinase/0.440