sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3cs8 | BRL | Peroxisome proliferator-activated receptor gamma |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3cs8 | BRL | Peroxisome proliferator-activated receptor gamma | / | 1.000 | |
| 1zgy | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.590 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.581 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.559 | |
| 3vso | EK1 | Peroxisome proliferator-activated receptor gamma | / | 0.558 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.556 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.549 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.544 | |
| 1fm6 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.540 | |
| 2q8s | L92 | Peroxisome proliferator-activated receptor gamma | / | 0.540 | |
| 4hee | 14R | Peroxisome proliferator-activated receptor gamma | / | 0.537 | |
| 3v9y | 24L | Peroxisome proliferator-activated receptor gamma | / | 0.534 | |
| 4f9m | FCM | Peroxisome proliferator-activated receptor gamma | / | 0.533 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.531 | |
| 2hfp | NSI | Peroxisome proliferator-activated receptor gamma | / | 0.529 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.527 | |
| 2gtk | 208 | Peroxisome proliferator-activated receptor gamma | / | 0.526 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.525 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.525 | |
| 1fm9 | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.523 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.522 | |
| 3vjh | J35 | Peroxisome proliferator-activated receptor gamma | / | 0.519 | |
| 1knu | YPA | Peroxisome proliferator-activated receptor gamma | / | 0.515 | |
| 4a4w | YFB | Peroxisome proliferator-activated receptor gamma | / | 0.511 | |
| 2q6s | PLB | Peroxisome proliferator-activated receptor gamma | / | 0.509 | |
| 2zno | S44 | Peroxisome proliferator-activated receptor gamma | / | 0.509 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.507 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.497 | |
| 4ema | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.492 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.486 | |
| 4em9 | TCE | Peroxisome proliferator-activated receptor gamma | / | 0.484 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.483 | |
| 3h0a | D30 | Peroxisome proliferator-activated receptor gamma | / | 0.482 | |
| 1i7i | AZ2 | Peroxisome proliferator-activated receptor gamma | / | 0.477 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.477 | |
| 1k74 | 544 | Peroxisome proliferator-activated receptor gamma | / | 0.476 | |
| 1nyx | DRF | Peroxisome proliferator-activated receptor gamma | / | 0.474 | |
| 2yfe | YFE | Peroxisome proliferator-activated receptor gamma | / | 0.468 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.467 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.461 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.458 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 3ndx | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.457 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.456 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.454 | |
| 3r8v | Z62 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 3ggx | GGX | Gag-Pol polyprotein | / | 0.451 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.450 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.449 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.449 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.449 | |
| 3nbv | ANP | Ketohexokinase | / | 0.449 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.448 | |
| 2izs | BRQ | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.447 | |
| 2q5p | 241 | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.447 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4mq1 | 2C3 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.447 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.446 | |
| 2nmy | ROC | Protease | / | 0.446 | |
| 3aid | ARQ | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.446 | |
| 3ufn | ROC | Gag-Pol polyprotein | / | 0.446 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.445 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.445 | |
| 2cdu | FAD | NADH oxidase | / | 0.443 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.443 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.441 | |
| 3lu7 | IPX | Serum albumin | / | 0.441 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3q92 | XNB | Ketohexokinase | / | 0.441 | |
| 3zpu | M8B | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4mvf | STU | Calcium-dependent protein kinase 2 | 2.7.11.1 | 0.441 | |
| 1d4l | PI9 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2fxe | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 |