sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.858 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.853 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.843 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.764 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.750 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.748 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.715 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.684 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.671 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.667 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.666 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.664 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.662 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.660 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.655 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.655 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.654 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.654 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.654 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.653 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.651 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.651 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.651 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.645 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.644 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.643 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.641 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.637 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.637 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.636 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.636 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.630 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.624 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.622 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.621 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.621 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.621 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.620 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.618 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.610 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.608 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.598 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.594 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.590 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.581 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.581 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.578 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.577 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.557 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.555 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.534 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.529 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.520 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.516 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.510 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.505 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.503 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.501 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.496 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.495 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.494 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.494 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.483 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.481 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.479 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.478 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.478 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.477 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.476 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.476 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.475 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.475 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.474 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.473 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.471 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.470 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.468 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.468 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.468 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.466 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.464 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.464 | |
| 3eej | 53R | Uncharacterized protein | / | 0.463 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.463 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.462 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.460 | |
| 3icr | FAD | Coenzyme A disulfide reductase | / | 0.460 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.460 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.460 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.459 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.459 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.459 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.458 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.458 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.458 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.458 | |
| 4dvq | 1CA | Cytochrome P450 11B2, mitochondrial | 1.14.15.4 | 0.457 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.456 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.455 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.454 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.454 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.453 | |
| 2y3s | TIR | TamL | / | 0.453 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.453 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.453 | |
| 1m9r | INE | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.452 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.452 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.452 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.452 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.452 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.451 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.451 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.450 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3au8 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.449 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.449 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.449 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.448 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.447 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.447 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.447 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.446 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.445 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.445 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.445 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.444 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.443 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.443 | |
| 4px9 | ADP | ATP-dependent RNA helicase DDX3X | 3.6.4.13 | 0.443 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 3gob | HXX | DdmC | / | 0.442 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.442 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 1zrq | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.441 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.441 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.441 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.441 | |
| 4egn | TWO | Cytochrome P450 | / | 0.441 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.441 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.441 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.440 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.440 |