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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3cp9C19Vascular endothelial growth factor receptor 22.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3cp9C19Vascular endothelial growth factor receptor 22.7.10.11.000
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.595
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.591
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.582
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.582
3hng8STVascular endothelial growth factor receptor 12.7.10.10.580
3efl706Vascular endothelial growth factor receptor 22.7.10.10.561
2hyySTITyrosine-protein kinase ABL12.7.10.20.552
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.537
2og81N8Tyrosine-protein kinase Lck2.7.10.20.532
1iepSTITyrosine-protein kinase ABL12.7.10.20.530
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.525
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.519
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.510
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.507
4o2z046Mitogen-activated protein kinase/0.507
2p2i608Vascular endothelial growth factor receptor 22.7.10.10.506
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.502
3hv5R24Mitogen-activated protein kinase 14/0.492
2xir00JVascular endothelial growth factor receptor 22.7.10.10.491
3vhkBPKVascular endothelial growth factor receptor 22.7.10.10.480
3eta351Insulin receptor2.7.10.10.478
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.477
4qrc0LIFibroblast growth factor receptor 42.7.10.10.475
4aa0AA0Mitogen-activated protein kinase 14/0.469
3ce31FNHepatocyte growth factor receptor2.7.10.10.466
4eyjN61Mitogen-activated protein kinase 132.7.11.240.465
3kq7KQ7Mitogen-activated protein kinase 14/0.461
3ctj320Hepatocyte growth factor receptor2.7.10.10.452
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.448
4eevL1XHepatocyte growth factor receptor2.7.10.10.442