sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3cnp | SP7 | Polyamine oxidase FMS1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3cnp | SP7 | Polyamine oxidase FMS1 | / | 1.000 | |
| 3bi4 | 298 | Polyamine oxidase FMS1 | / | 0.628 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.511 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.508 | |
| 4f3g | KAI | Glutamate receptor 3 | / | 0.492 | |
| 1lbb | KAI | Glutamate receptor 2 | / | 0.491 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.488 | |
| 3ab1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.485 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.484 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.482 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.482 | |
| 1knp | FAD | L-aspartate oxidase | 1.4.3.16 | 0.481 | |
| 3e6e | DCS | Alanine racemase | / | 0.480 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.479 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.479 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.478 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.477 | |
| 2b5o | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.476 | |
| 3b9x | NOS | Pyrimidine-specific ribonucleoside hydrolase RihB | 3.2.2.8 | 0.475 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.474 | |
| 3dz7 | O8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.474 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.474 | |
| 4l5a | TBN | S-methyl-5'-thioadenosine phosphorylase | / | 0.474 | |
| 4z4p | SAH | Histone-lysine N-methyltransferase 2D | 2.1.1.43 | 0.474 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.473 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.472 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.472 | |
| 4wqm | FAD | Toluene-4-monooxygenase electron transfer component | 1.18.1.3 | 0.472 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.471 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.471 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.471 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.471 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.471 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.470 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.470 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.470 | |
| 5cyo | GDP | Septin-9 | / | 0.470 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.469 | |
| 1zny | GDP | Guanylate kinase | 2.7.4.8 | 0.469 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.469 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.469 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.468 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.468 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.468 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.467 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 1v93 | FAD | Methylenetetrahydrofolate reductase | / | 0.467 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.467 | |
| 3iaa | TYD | CalG2 | / | 0.467 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.467 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.466 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.465 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.465 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.465 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.465 | |
| 1ty9 | FMN | Phenazine biosynthesis protein PhzG | 1.4 | 0.464 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2rc6 | FAD | Ferredoxin--NADP reductase | / | 0.464 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.464 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.462 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.462 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.462 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.462 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.462 | |
| 3h0w | N8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.462 | |
| 3s8p | SAM | Histone-lysine N-methyltransferase KMT5B | 2.1.1.43 | 0.462 | |
| 3uxe | 465 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.462 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.462 | |
| 4iil | RBF | Membrane lipoprotein TpN38(b) | / | 0.462 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.461 | |
| 2db3 | ANP | ATP-dependent RNA helicase vasa, isoform A | 3.6.4.13 | 0.461 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.461 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.461 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.461 | |
| 4yqf | GDP | Septin-9 | / | 0.461 | |
| 5czy | SAM | Eukaryotic huntingtin interacting protein B | / | 0.461 | |
| 1n77 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.460 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.460 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.459 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.459 | |
| 2g6p | HM2 | Methionine aminopeptidase 1 | / | 0.459 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.459 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.459 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3nd6 | ATP | Phosphopantetheine adenylyltransferase | / | 0.459 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.459 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.459 | |
| 3zhu | TD8 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.459 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.459 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.459 | |
| 5egh | PC | Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 | / | 0.459 | |
| 1e80 | 0GQ | Endothiapepsin | 3.4.23.22 | 0.458 | |
| 1fnd | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.458 | |
| 1jum | BER | HTH-type transcriptional regulator QacR | / | 0.458 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.458 | |
| 2bf4 | FAD | NADPH--cytochrome P450 reductase | / | 0.458 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.458 | |
| 1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.457 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.457 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.457 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.457 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.457 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.456 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.456 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.456 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.456 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.455 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.455 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.455 | |
| 4lh7 | 1X8 | DNA ligase | / | 0.455 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.455 | |
| 4tm0 | FAD | KtzI | / | 0.455 | |
| 1a7x | FKA | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.454 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.454 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3rba | COD | Phosphopantetheine adenylyltransferase | / | 0.454 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.454 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.454 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.453 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.453 | |
| 3e4a | QIX | Insulin-degrading enzyme | 3.4.24.56 | 0.453 | |
| 3g0b | T22 | Dipeptidyl peptidase 4 | / | 0.453 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.453 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.453 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.453 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.453 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.452 | |
| 1fw0 | KAI | Glutamate receptor 2 | / | 0.452 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.452 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.452 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.452 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.452 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.452 | |
| 3w5h | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.452 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4e47 | 0N6 | Histone-lysine N-methyltransferase SETD7 | 2.1.1.43 | 0.452 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.452 | |
| 4qen | SAH | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 | 2.1.1.43 | 0.452 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.452 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.451 | |
| 2bn4 | FMN | NADPH--cytochrome P450 reductase | / | 0.451 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.451 | |
| 3kek | 3EK | Collagenase 3 | 3.4.24 | 0.451 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3rdq | DTB | Streptavidin | / | 0.451 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4j0t | 6T9 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4j4n | D44 | Peptidylprolyl isomerase | / | 0.451 | |
| 1ee9 | NAD | Methylenetetrahydrofolate dehydrogenase [NAD(+)] | 1.5.1.15 | 0.450 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2jh0 | 701 | Prothrombin | 3.4.21.5 | 0.450 | |
| 2o3u | NGD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.450 | |
| 3arv | SAU | Chitinase A | / | 0.450 | |
| 4ikz | AFS | Di-tripeptide ABC transporter (Permease) | / | 0.450 | |
| 4to4 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.450 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 2gz7 | D3F | Orf1a polyprotein | / | 0.449 | |
| 2jgs | BTN | Avidin | / | 0.449 | |
| 2v5u | FMN | Flavodoxin | / | 0.449 | |
| 2xtk | AZM | Class III chitinase ChiA1 | / | 0.449 | |
| 2zbw | FAD | Ferredoxin--NADP reductase | / | 0.449 | |
| 3hna | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.449 | |
| 3ld6 | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.449 | |
| 4nv1 | TYD | Formyl transferase | / | 0.449 | |
| 4u3j | GTP | Tubulin beta chain | / | 0.449 | |
| 4y9r | FAD | NADPH--cytochrome P450 reductase | / | 0.449 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.448 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.448 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 2ejz | SAH | Diphthine synthase | / | 0.448 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.448 | |
| 2owf | SAH | Diphthine synthase | / | 0.448 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 3bt9 | DEQ | HTH-type transcriptional regulator QacR | / | 0.448 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.448 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.448 | |
| 3kkz | SAM | Uncharacterized protein | / | 0.448 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.448 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.448 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.448 | |
| 4iks | TFD | Methionine aminopeptidase 1 | / | 0.448 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.448 | |
| 4r5w | XAV | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.448 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.448 | |
| 1oxo | IK2 | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.447 | |
| 1ptj | NAP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.447 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.447 | |
| 2q92 | B23 | Methionine aminopeptidase | / | 0.447 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.447 | |
| 3gn2 | AX8 | Pteridine reductase | / | 0.447 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.447 | |
| 4eyf | PNK | Metallo-beta-lactamase type 2 | / | 0.447 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.447 | |
| 4xg1 | LLP | Diaminopimelate decarboxylase | / | 0.447 | |
| 4xmx | BES | Aminopeptidase N | 3.4.11.2 | 0.447 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.447 | |
| 5ex0 | SAH | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.447 | |
| 1csc | CMC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.446 | |
| 1h85 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.446 | |
| 1u33 | LM2 | Pancreatic alpha-amylase | / | 0.446 | |
| 2fxf | ACO | Diamine acetyltransferase 1 | / | 0.446 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.446 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.446 | |
| 3bl7 | DD1 | m7GpppX diphosphatase | 3.6.1.59 | 0.446 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.446 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 3rfa | SAM | Dual-specificity RNA methyltransferase RlmN | / | 0.446 | |
| 3tza | TZG | Glutamate receptor 2 | / | 0.446 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.446 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.446 | |
| 1gvr | TNL | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.445 | |
| 1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.445 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.445 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.445 | |
| 3t0i | SAH | Putative methyltransferase | / | 0.445 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.445 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 4nec | SAH | Putative SAM-dependent methyltransferase | / | 0.445 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.445 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.445 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.444 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.444 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.444 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.444 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.444 | |
| 3ioe | A7D | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 3muo | ZPR | Prolyl endopeptidase | / | 0.444 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.444 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.444 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 4lay | I63 | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.444 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.444 | |
| 4xba | GMP | Aprataxin-like protein | 3 | 0.444 | |
| 5hvn | NAD | 3-dehydroquinate synthase | / | 0.444 | |
| 1dnp | MHF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.443 | |
| 2bf4 | FMN | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 3i5x | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.443 | |
| 3o7b | SAH | Ribosomal RNA small subunit methyltransferase Nep1 | / | 0.443 | |
| 3pi5 | 3P5 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.443 | |
| 3s5w | FAD | L-ornithine N(5)-monooxygenase | / | 0.443 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.443 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.443 | |
| 1d2h | SAH | Glycine N-methyltransferase | 2.1.1.20 | 0.442 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.442 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.442 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.442 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.442 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.442 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.442 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3g0g | RUM | Dipeptidyl peptidase 4 | / | 0.442 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.442 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.442 | |
| 3koy | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.442 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 3s7d | LEU_SER_LYS_LYS_MLZ | N-lysine methyltransferase SMYD2 | / | 0.442 | |
| 3u04 | BB2 | Peptide deformylase | / | 0.442 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.442 | |
| 4cb7 | 41G | Polymerase basic protein 2 | / | 0.442 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.442 | |
| 4m2b | UPG | UDP-glucose pyrophosphorylase | / | 0.442 | |
| 5jj0 | SAM | Histone-lysine N-methyltransferase EHMT2 | / | 0.442 | |
| 3pbl | ETQ | D(3) dopamine receptor | / | 0.442 | |
| 1dmw | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.441 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.441 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.441 | |
| 2vb8 | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.441 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 3qvs | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.441 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.441 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.441 | |
| 4d6q | PD2 | Lysine-specific demethylase 4D | 1.14.11 | 0.441 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.441 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.441 | |
| 5hq8 | SAH | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.441 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.440 | |
| 1n75 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.440 | |
| 1vce | SAH | Diphthine synthase | / | 0.440 | |
| 1zp9 | ATP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.440 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.440 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3e78 | TPP | High affinity transport system protein p37 | / | 0.440 | |
| 3ox1 | 695 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.440 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.440 | |
| 4az3 | S35 | Lysosomal protective protein | 3.4.16.5 | 0.440 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4gd4 | 0WS | Lysine-specific demethylase 4A | 1.14.11 | 0.440 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.440 |