scPDB - Distribution of Binding site Similarity values of 3clb entry / Site 2

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	1.000
3qly	55V	Uncharacterized protein	/	0.549
3cse	N22	Uncharacterized protein	/	0.545
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.539
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.539
3qlx	QLR	Uncharacterized protein	/	0.524
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.522
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.518
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.516
3eel	53T	Uncharacterized protein	/	0.515
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.511
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.511
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.510
3eem	53V	Uncharacterized protein	/	0.509
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.507
4h98	14Q	Uncharacterized protein	/	0.505
3eek	53S	Uncharacterized protein	/	0.499
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.499
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.497
3eej	53R	Uncharacterized protein	/	0.496
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.495
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.492
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.491
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.489
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.488
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.487
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.485
3qlz	QLZ	Uncharacterized protein	/	0.484
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.482
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.481
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.481
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.475
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.473
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.470
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.470
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.468
1ly4	COQ	Dihydrofolate reductase	1.5.1.3	0.468
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.466
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.461
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.461
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.460
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.460
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.458
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.457
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.457
2w3v	TOP	Dihydrofolate reductase	/	0.456
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.456
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.455
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.454
2y98	MIV	Mycinamicin IV hydroxylase/epoxidase	/	0.451
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.451
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.450
3vt7	VDX	Vitamin D3 receptor	/	0.447
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.445
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.445
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.444
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.442
3aba	FLI	Cytochrome P450	/	0.442
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.441
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.440