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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3cjgKIMVascular endothelial growth factor receptor 22.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3cjgKIMVascular endothelial growth factor receptor 22.7.10.11.000
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.574
4nks2M2Fibroblast growth factor receptor 1/0.572
4nka2K7Fibroblast growth factor receptor 1/0.568
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.566
4f640S8Fibroblast growth factor receptor 1/0.555
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.533
4j95ACPFibroblast growth factor receptor 2/0.525
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.524
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.520
2pwlACPFibroblast growth factor receptor 2/0.519
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.516
2py3ACPFibroblast growth factor receptor 2/0.515
4ic7ANPMitogen-activated protein kinase 72.7.11.240.515
3zewSTUEphrin type-B receptor 42.7.10.10.513
3js2VM1Fibroblast growth factor receptor 1/0.512
4j97ACPFibroblast growth factor receptor 2/0.512
4fob0USALK tyrosine kinase receptor2.7.10.10.510
4gmy0X5Tyrosine-protein kinase JAK2/0.510
3s4qNK0Mitogen-activated protein kinase 14/0.509
4gk2L66Ephrin type-A receptor 32.7.10.10.508
4gk4L90Ephrin type-A receptor 32.7.10.10.507
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.506
2hog710Serine/threonine-protein kinase Chk12.7.11.10.506
4hvh19RTyrosine-protein kinase JAK32.7.10.20.505
2xyuQ9GEphrin type-A receptor 42.7.10.10.504
4anqVGHALK tyrosine kinase receptor2.7.10.10.504
2hk51BMTyrosine-protein kinase HCK2.7.10.20.502
3vjoANPEpidermal growth factor receptor2.7.10.10.502
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.501
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.501
4c62XWWTyrosine-protein kinase JAK2/0.501
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.500
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.500
4jia1K3Tyrosine-protein kinase JAK2/0.500
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.500
5aaaVGHALK tyrosine kinase receptor2.7.10.10.500
2fgiPD1Fibroblast growth factor receptor 1/0.499
4nk92K5Fibroblast growth factor receptor 1/0.499
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.497
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.496
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.495
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.495
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.495
5aacVGHALK tyrosine kinase receptor2.7.10.10.494
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.493
2itqITQEpidermal growth factor receptor2.7.10.10.493
2of2547Tyrosine-protein kinase Lck2.7.10.20.493
2yn8STUEphrin type-B receptor 42.7.10.10.493
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.492
4wkqIREEpidermal growth factor receptor2.7.10.10.492
4aotGW8Serine/threonine-protein kinase 102.7.11.10.491
4f630S7Fibroblast growth factor receptor 1/0.491
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.490
2j7t274Serine/threonine-protein kinase 102.7.11.10.490
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.490
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.490
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.490
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.489
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.489
3w2sW2REpidermal growth factor receptor2.7.10.10.489
1m17AQ4Epidermal growth factor receptor2.7.10.10.488
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.488
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.488
3uvqFS8Mitogen-activated protein kinase 14/0.486
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.485
2q0bACPFibroblast growth factor receptor 2/0.485
3a62STURibosomal protein S6 kinase beta-12.7.11.10.484
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.484
1finATPCyclin-dependent kinase 22.7.11.220.483
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.483
4cd0AWJALK tyrosine kinase receptor2.7.10.10.483
4gk3L87Ephrin type-A receptor 32.7.10.10.483
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.483
2xp2VGHALK tyrosine kinase receptor2.7.10.10.482
2zybKSLTyrosine-protein kinase Lck2.7.10.20.482
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.482
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.482
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.482
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.481
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.481
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.481
3flsFLSMitogen-activated protein kinase 14/0.479
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.479
5aabVGHALK tyrosine kinase receptor2.7.10.10.479
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.478
2i0ePDSProtein kinase C beta type2.7.11.130.478
2vwu7X1Ephrin type-B receptor 42.7.10.10.478
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.478
4hvg19QTyrosine-protein kinase JAK32.7.10.20.478
4id71G0Activated CDC42 kinase 1/0.478
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.478
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.477
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.477
4bcmT7ZCyclin-dependent kinase 22.7.11.220.477
4btkDTQTau-tubulin kinase 12.7.11.10.477
2c6eHPMAurora kinase A2.7.11.10.476
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.476
4i231C9Epidermal growth factor receptor2.7.10.10.476
2of4979Tyrosine-protein kinase Lck2.7.10.20.475
2vd5BI8Myotonin-protein kinase2.7.11.10.475
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.474
4e4m0NHTyrosine-protein kinase JAK2/0.474
4j99ACPFibroblast growth factor receptor 2/0.474
1pkdUCNCyclin-dependent kinase 22.7.11.220.473
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.473
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.473
3gc9B45Mitogen-activated protein kinase 112.7.11.240.473
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.473
4k33ACPFibroblast growth factor receptor 32.7.10.10.473
1zyjBI5Mitogen-activated protein kinase 14/0.472
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.472
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.472
3t8oATPRhodopsin kinase/0.472
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.471
4hvi19STyrosine-protein kinase JAK32.7.10.20.471
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.471
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.471
2itzIREEpidermal growth factor receptor2.7.10.10.470
5dr9SKEAurora kinase A2.7.11.10.470
1yvj4STTyrosine-protein kinase JAK32.7.10.20.469
2etm7PYFocal adhesion kinase 12.7.10.20.469
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.469
4ansVGHALK tyrosine kinase receptor2.7.10.10.469
2bujSTUSerine/threonine-protein kinase 16/0.468
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.468
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.468
2qoqANPEphrin type-A receptor 32.7.10.10.467
2y6o1N1Ephrin type-A receptor 42.7.10.10.467
2yfxVGHALK tyrosine kinase receptor2.7.10.10.467
3eb0DRKUncharacterized protein/0.467
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.467
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.467
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.466
2pzpACPFibroblast growth factor receptor 2/0.466
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.466
3vs3VSETyrosine-protein kinase HCK2.7.10.20.466
4jq8KJ8Epidermal growth factor receptor2.7.10.10.466
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.465
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.465
2qo9ANPEphrin type-A receptor 32.7.10.10.465
2xvdAS6Ephrin type-B receptor 42.7.10.10.465
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.465
3c4xATPRhodopsin kinase/0.465
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.465
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.465
2eb3ANPEpidermal growth factor receptor2.7.10.10.464
3oom507Activin receptor type-12.7.11.300.464
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.464
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.464
4jrvKJVEpidermal growth factor receptor2.7.10.10.464
2itpAEEEpidermal growth factor receptor2.7.10.10.463
3mvl38PMitogen-activated protein kinase 14/0.463
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.463
3w33W19Epidermal growth factor receptor2.7.10.10.463
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.463
4jr3KJREpidermal growth factor receptor2.7.10.10.463
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.463
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.462
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.462
1zrzBI1Protein kinase C iota type2.7.11.130.460
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.460
2x6dX6DAurora kinase A2.7.11.10.460
3dt1P40Mitogen-activated protein kinase 14/0.460
3q92XNBKetohexokinase/0.460
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.460
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.460
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.459
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.459
4bcqTJFCyclin-dependent kinase 22.7.11.220.459
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.459
4y93746Tyrosine-protein kinase/0.459
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.458
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.458
4fnzNZFALK tyrosine kinase receptor2.7.10.10.458
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.458
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
2vwx7X4Ephrin type-B receptor 42.7.10.10.457
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.457
5e8xSTUTGF-beta receptor type-12.7.11.300.457
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.456
2itwITQEpidermal growth factor receptor2.7.10.10.456
3fln3FNMitogen-activated protein kinase 14/0.456
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.456
3qc9ADPRhodopsin kinase/0.456
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.456
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.456
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.456
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.455
3uvp048Mitogen-activated protein kinase 14/0.455
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.455
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.455
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.455
1bygSTUTyrosine-protein kinase CSK/0.454
1oecAA2Fibroblast growth factor receptor 2/0.454
3d7tSTUTyrosine-protein kinase CSK/0.454
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.454
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.454
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.454
4riyADPEpidermal growth factor receptor2.7.10.10.454
1ouy094Mitogen-activated protein kinase 14/0.453
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.453
2io6330Wee1-like protein kinase2.7.10.20.453
2j0m4STFocal adhesion kinase 12.7.10.20.453
2vx07X7Ephrin type-B receptor 42.7.10.10.453
3emg685Tyrosine-protein kinase SYK2.7.10.20.453
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.453
5auwQUEDeath-associated protein kinase 12.7.11.10.453
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.452
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
2pz5ACPFibroblast growth factor receptor 2/0.452
2v7a627Tyrosine-protein kinase ABL12.7.10.20.452
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.452
3hllI45Mitogen-activated protein kinase 14/0.452
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
3a7hATPSerine/threonine-protein kinase 242.7.11.10.451
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.451
4hyu1BKMitogen-activated protein kinase 82.7.11.240.451
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.451
2i40BLZCyclin-dependent kinase 22.7.11.220.450
2ittAEEEpidermal growth factor receptor2.7.10.10.450
3cqeP91Wee1-like protein kinase2.7.10.20.450
3flwFLWMitogen-activated protein kinase 14/0.450
3l8p0CEAngiopoietin-1 receptor2.7.10.10.450
4xhgADPUncharacterized protein/0.450
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.449
1wvxBD4Death-associated protein kinase 12.7.11.10.449
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.449
3r7iX9ICyclin-dependent kinase 22.7.11.220.449
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.449
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.449
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.449
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.449
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.449
4nj32KDCyclin-dependent kinase 22.7.11.220.449
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.449
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.448
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.448
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.448
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.448
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.448
3qaiXNNKetohexokinase/0.448
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.448
4b99R4LMitogen-activated protein kinase 72.7.11.240.448
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.448
4jqeANPCasein kinase II subunit alpha2.7.11.10.448
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.447
2vx17X8Ephrin type-B receptor 42.7.10.10.447
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.447
2z2w770Wee1-like protein kinase2.7.10.20.447
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.447
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.447
4g1wG1WMitogen-activated protein kinase 82.7.11.240.447
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.447
4mcc21XtRNA (guanine-N(1)-)-methyltransferase2.1.1.2280.447
2xa4AZ5Tyrosine-protein kinase JAK2/0.446
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.446
3ac2KSETyrosine-protein kinase Lck2.7.10.20.446
3hx4ANPCalmodulin-domain protein kinase 1/0.446
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.446
3tucFPWTyrosine-protein kinase SYK2.7.10.20.446
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.446
1ove358Mitogen-activated protein kinase 14/0.445
1v1k3FPCyclin-dependent kinase 22.7.11.220.445
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.445
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.445
3w2rW2REpidermal growth factor receptor2.7.10.10.445
1g5sI17Cyclin-dependent kinase 22.7.11.220.444
2fvdLIACyclin-dependent kinase 22.7.11.220.444
2itnANPEpidermal growth factor receptor2.7.10.10.444
2izsBRQCasein kinase I isoform gamma-32.7.11.10.444
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.444
3cjfSAVVascular endothelial growth factor receptor 22.7.10.10.444
3gubGUBDeath-associated protein kinase 12.7.11.10.444
4aa4QC0Mitogen-activated protein kinase 14/0.444
4gub0Y4Casein kinase II subunit alpha2.7.11.10.444
4qmlANPSerine/threonine-protein kinase 242.7.11.10.444
4tyj0LIFibroblast growth factor receptor 42.7.10.10.444
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.443
3ac1KZITyrosine-protein kinase Lck2.7.10.20.443
3bi6396Wee1-like protein kinase2.7.10.20.443
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.443
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.443
3w2o03PEpidermal growth factor receptor2.7.10.10.443
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.443
4iebANPCalmodulin-domain protein kinase 1/0.443
5e8wSTUTGF-beta receptor type-12.7.11.300.443
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.442
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.442
3jvwDMPGag-Pol polyprotein3.4.23.160.442
3zh8C58Protein kinase C iota type2.7.11.130.442
3zptM8YGag-Pol polyprotein3.4.23.160.442
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.442
2izrBRKCasein kinase I isoform gamma-32.7.11.10.441
3c50ADPRhodopsin kinase/0.441
3iphG11Mitogen-activated protein kinase 14/0.441
3iw4LW4Protein kinase C alpha type2.7.11.130.441
3s2pPMUCyclin-dependent kinase 22.7.11.220.441
3tnwF18Cyclin-dependent kinase 22.7.11.220.441
4erwSTUCyclin-dependent kinase 22.7.11.220.441
4i22IREEpidermal growth factor receptor2.7.10.10.441
4wboANWRhodopsin kinase/0.441
1fvv107Cyclin-dependent kinase 22.7.11.220.440
1u54ACPActivated CDC42 kinase 1/0.440
2j0j4STFocal adhesion kinase 12.7.10.20.440
2j0k4STFocal adhesion kinase 12.7.10.20.440
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.440
4bcnT9NCyclin-dependent kinase 22.7.11.220.440
4d9t0JGRibosomal protein S6 kinase alpha-32.7.11.10.440
4g2fC07Ephrin type-A receptor 32.7.10.10.440
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.440