scPDB - Distribution of Binding site Similarity values of 3cj3 entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3cj3	SX4	Genome polyprotein	2.7.7.48

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3cj3	SX4	Genome polyprotein	2.7.7.48	1.000
1nhv	154	Genome polyprotein	2.7.7.48	0.572
4jvq	1ML	Genome polyprotein	2.7.7.48	0.570
4ju2	1O0	Genome polyprotein	2.7.7.48	0.551
2d3u	CCT	Polyprotein	/	0.549
4jty	1NV	Genome polyprotein	2.7.7.48	0.544
2gir	NN3	Genome polyprotein	2.7.7.48	0.542
3phe	C9A	RNA-directed RNA polymerase	/	0.542
4ju1	1NZ	Genome polyprotein	2.7.7.48	0.525
3frz	AG0	Genome polyprotein	2.7.7.48	0.520
4jtz	1NW	Genome polyprotein	2.7.7.48	0.520
4j06	1JG	Genome polyprotein	2.7.7.48	0.516
4jtw	1NU	Genome polyprotein	2.7.7.48	0.515
2o5d	VR1	Genome polyprotein	2.7.7.48	0.510
2hwh	RNA	Genome polyprotein	2.7.7.48	0.502
4ju4	1O3	Genome polyprotein	2.7.7.48	0.491
4jju	1MB	Genome polyprotein	2.7.7.48	0.488
1z2n	ADP	Inositol-tetrakisphosphate 1-kinase	2.7.1.134	0.484
2xae	2XA	Kinesin-like protein KIF11	/	0.483
4b8z	GDP	GDP-L-fucose synthase	1.1.1.271	0.477
1e1q	ADP	ATP synthase subunit beta, mitochondrial	3.6.3.14	0.474
2hai	PFI	Polyprotein	/	0.474
2rl5	2RL	Vascular endothelial growth factor receptor 2	2.7.10.1	0.473
4a51	DQ8	Kinesin-like protein KIF11	/	0.472
3tdl	11D	Serum albumin	/	0.467
4g2i	0VQ	Vitamin D3 receptor	/	0.467
4a6e	ASE	Acetylserotonin O-methyltransferase	2.1.1.4	0.466
4hw2	19H	Induced myeloid leukemia cell differentiation protein Mcl-1	/	0.466
3pd4	A3G	Threonine--tRNA ligase	6.1.1.3	0.464
2hvd	ADP	Nucleoside diphosphate kinase A	2.7.4.6	0.462
2ybo	SAH	Methyltransferase	/	0.462
5cwa	0GA	Anthranilate synthase component 1	4.1.3.27	0.462
1u1f	183	Uridine phosphorylase	2.4.2.3	0.461
4ap1	NAP	Steroid monooxygenase	/	0.461
3c0g	3AM	Peripheral plasma membrane protein CASK	2.7.11.1	0.460
4kf1	HT5	Aryldialkylphosphatase	3.1.8.1	0.460
4mob	COA	Acyl-coenzyme A thioesterase 12	3.1.2.1	0.459
3cem	AVD	Glycogen phosphorylase, liver form	2.4.1.1	0.458
3zc5	W9Z	Hepatocyte growth factor receptor	2.7.10.1	0.458
4f79	P53	Putative phospho-beta-glucosidase	/	0.458
5doz	NDP	JamJ	/	0.458
3njo	P2M	Abscisic acid receptor PYR1	/	0.456
4eer	FMN	Phototropin-2	2.7.11.1	0.456
2gjn	FMN	Nitronate monooxygenase	1.13.12.16	0.455
2w5b	AGS	Serine/threonine-protein kinase Nek2	2.7.11.1	0.455
3el8	PD5	Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	0.455
4oha	HFT	Androgen receptor	/	0.455
5ej4	TD6	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	/	0.455
1s4d	SAH	Uroporphyrinogen-III C-methyltransferase	2.1.1.107	0.454
1upw	444	Oxysterols receptor LXR-beta	/	0.454
2j9g	ADP	Biotin carboxylase	6.3.4.14	0.454
2ati	IHU	Glycogen phosphorylase, liver form	2.4.1.1	0.453
2bue	COA	AAC(6')-Ib	/	0.453
2p6l	SAH	Diphthine synthase	/	0.453
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.453
3pqb	VGP	Putative oxidoreductase	/	0.453
4xyb	NDP	Formate dehydrogenase	/	0.453
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.452
1n83	CLR	Nuclear receptor ROR-alpha	/	0.452
2rhr	EMO	Putative ketoacyl reductase	1.3.1	0.452
3b9l	AZZ	Serum albumin	/	0.452
3i6r	J5Z	Dihydroorotate dehydrogenase (quinone), mitochondrial	1.3.5.2	0.452
4bfu	ZVU	Pantothenate kinase	2.7.1.33	0.452
4rkf	GNP	Ras-related protein Rab-3	/	0.452
4y8w	STR	Steroid 21-hydroxylase	/	0.452
1w06	W05	Isopenicillin N synthase	1.21.3.1	0.451
2h94	FAD	Lysine-specific histone demethylase 1A	1	0.451
2p6i	SAH	Diphthine synthase	/	0.451
3ada	NAD	Subunit alpha of sarocosine oxidase	/	0.451
4jv8	1M1	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	/	0.451
1dgh	NDP	Catalase	1.11.1.6	0.450
1lru	BB2	Peptide deformylase	3.5.1.88	0.450
2gev	COK	Pantothenate kinase	2.7.1.33	0.450
4gzl	GNP	Ras-related C3 botulinum toxin substrate 1	/	0.450
1vbi	NAD	Malate/L-lactate dehydrogenase family protein	/	0.449
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.449
4ork	GDP	Bifunctional AAC/APH	2.3.1	0.449
1ivr	CBA	Aspartate aminotransferase, mitochondrial	2.6.1.1	0.448
1uog	P1C	Deacetoxycephalosporin C synthase	1.14.20.1	0.448
2bpo	NAP	NADPH--cytochrome P450 reductase	/	0.448
2c59	NAD	GDP-mannose 3,5-epimerase	5.1.3.18	0.448
2g1q	N9H	Kinesin-like protein KIF11	/	0.448
2vo4	GTB	2,4-D inducible glutathione S-transferase	/	0.448
3d74	NBB	Pheromone-binding protein ASP1	/	0.448
2bxi	AZQ	Serum albumin	/	0.447
2jkc	FAD	Flavin-dependent tryptophan halogenase PrnA	1.14.19.9	0.447
4bfr	J82	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	2.7.1.153	0.447
4j8t	DOG	Uncharacterized PhzA/B-like protein PA3332	/	0.447
1b2l	NDC	Alcohol dehydrogenase	1.1.1.1	0.446
1gpe	FAD	Glucose oxidase	1.1.3.4	0.446
3fr2	8CA	Fatty acid-binding protein, adipocyte	/	0.446
4cav	MYA	Glycylpeptide N-tetradecanoyltransferase	2.3.1.97	0.446
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.446
4xgx	ADP	FAD:protein FMN transferase	/	0.446
5g53	NEC	Adenosine receptor A2a	/	0.446
1gwn	GTP	Rho-related GTP-binding protein RhoE	/	0.445
2ahv	COA	Acetate CoA-transferase YdiF	2.8.3.8	0.445
2ban	357	Gag-Pol polyprotein	2.7.7.49	0.445
2g78	REA	Cellular retinoic acid-binding protein 2	/	0.445
2hb8	MVD	Vitamin D3 receptor	/	0.445
2vgp	AD6	Aurora kinase B-A	2.7.11.1	0.445
3h3t	16H	Collagen type IV alpha-3-binding protein	/	0.445
3lfm	3DT	Alpha-ketoglutarate-dependent dioxygenase FTO	/	0.445
3uax	NOS	Purine nucleoside phosphorylase DeoD-type	/	0.445
4b4d	FAD	Ferredoxin-NADP reductase	/	0.445
4b7p	9UN	Heat shock protein HSP 90-alpha	/	0.445
4iah	1DX	Alr2278 protein	/	0.445
4xnh	ACO	N-terminal acetyltransferase A complex subunit NAT5	2.3.1	0.445
1lfd	GNP	GTPase HRas	/	0.444
2jlb	UDM	Uncharacterized protein	/	0.444
2x7e	X7E	Kinesin-like protein KIF11	/	0.444
4bn1	ADP	Aurora kinase A	2.7.11.1	0.444
1akb	PPD	Aspartate aminotransferase, mitochondrial	2.6.1.1	0.443
1bnw	TPD	Carbonic anhydrase 2	4.2.1.1	0.443
1j7l	ADP	Aminoglycoside 3'-phosphotransferase	2.7.1.95	0.443
1lqu	NDP	NADPH-ferredoxin reductase FprA	1.18.1.2	0.443
1v8k	ANP	Kinesin-like protein KIF2C	/	0.443
3wyg	GTP	GTP-binding nuclear protein GSP1/CNR1	/	0.443
4cj5	4VW	Integrase	/	0.443
4jld	ADP	Adenylate kinase	/	0.443
4lb2	DM5	Serum albumin	/	0.443
4y9l	FAD	Acyl-CoA dehydrogenase family member 11	/	0.443
8cat	NDP	Catalase	1.11.1.6	0.443
1fp1	HCC	Isoliquiritigenin 2'-O-methyltransferase	/	0.442
1uuo	BRF	Dihydroorotate dehydrogenase (quinone), mitochondrial	1.3.5.2	0.442
1z2p	ACP	Inositol-tetrakisphosphate 1-kinase	2.7.1.134	0.442
2b0q	ADP	Aminoglycoside 3'-phosphotransferase	2.7.1.95	0.442
2qo6	CHD	Fatty acid-binding protein 10-A, liver basic	/	0.442
3d76	NBB	Pheromone-binding protein ASP1	/	0.442
3ln1	CEL	Prostaglandin G/H synthase 2	1.14.99.1	0.442
3rv7	RVB	Salicylate synthase	/	0.442
3sgv	2BJ	Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	2.5.1.31	0.442
3up4	NAP	2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase	1.14.13.160	0.442
5ans	RX8	7,8-dihydro-8-oxoguanine triphosphatase	3.6.1.55	0.442
1rek	B8L	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.441
2bx8	AZQ	Serum albumin	/	0.441
2ij7	TPF	Mycocyclosin synthase	1.14.21.9	0.441
2rgc	GNP	GTPase HRas	/	0.441
3rc7	TLO	Sugar 3-ketoreductase	/	0.441
3x1w	GDP	Ras-related protein Rap-1b	/	0.441
4eev	L1X	Hepatocyte growth factor receptor	2.7.10.1	0.441
1fm8	DDC	Chalcone--flavonone isomerase 1	5.5.1.6	0.440
1hlk	113	Metallo-beta-lactamase type 2	/	0.440
1x2h	LPA	Lipoate-protein ligase A	6.3.1.20	0.440
1xl8	152	Peroxisomal carnitine O-octanoyltransferase	2.3.1.137	0.440
1ygk	RRC	Pyridoxal kinase	2.7.1.35	0.440
3d75	NBB	Pheromone-binding protein ASP1	/	0.440
3n8w	FLP	Prostaglandin G/H synthase 1	1.14.99.1	0.440
4elg	52J	Dihydrofolate reductase	/	0.440
4ffl	ADP	Uncharacterized protein	/	0.440
4g47	TZF	Mycocyclosin synthase	1.14.21.9	0.440
4obe	GDP	GTPase KRas	/	0.440
4pkw	GM6	Lethal factor	3.4.24.83	0.440