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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3cgfJNFMitogen-activated protein kinase 102.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3cgfJNFMitogen-activated protein kinase 102.7.11.241.000
2p33J07Mitogen-activated protein kinase 102.7.11.240.714
3ttjJBIMitogen-activated protein kinase 102.7.11.240.594
3cgoJNOMitogen-activated protein kinase 102.7.11.240.586
2zdt46CMitogen-activated protein kinase 102.7.11.240.576
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.575
3eljGS7Mitogen-activated protein kinase 82.7.11.240.559
2excJNKMitogen-activated protein kinase 102.7.11.240.557
1pmn984Mitogen-activated protein kinase 102.7.11.240.541
1bygSTUTyrosine-protein kinase CSK/0.526
2xrwANPMitogen-activated protein kinase 82.7.11.240.524
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.518
2xs0ANPMitogen-activated protein kinase 82.7.11.240.515
3ttiKBIMitogen-activated protein kinase 102.7.11.240.513
1jnkANPMitogen-activated protein kinase 102.7.11.240.508
4g1wG1WMitogen-activated protein kinase 82.7.11.240.508
5awmANPStress-activated protein kinase JNK2.7.11.240.507
4btjATPTau-tubulin kinase 12.7.11.10.506
4ux9ANPMitogen-activated protein kinase 82.7.11.240.506
4jia1K3Tyrosine-protein kinase JAK2/0.503
3ggfGVDSerine/threonine-protein kinase 26/0.502
4btjADPTau-tubulin kinase 12.7.11.10.499
4e730NRMitogen-activated protein kinase 82.7.11.240.498
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.498
3kvxFMYMitogen-activated protein kinase 102.7.11.240.497
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.496
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.495
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.493
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.492
3be9P04Casein kinase II subunit alpha2.7.11.10.491
2b1pAIZMitogen-activated protein kinase 102.7.11.240.490
4hyu1BKMitogen-activated protein kinase 82.7.11.240.490
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.489
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.488
2pvnP63Casein kinase II subunit alpha2.7.11.10.488
4j95ACPFibroblast growth factor receptor 2/0.488
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.487
2henADPEphrin type-B receptor 22.7.10.10.486
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.486
4lrjANPUncharacterized protein/0.486
5e8ySTUTGF-beta receptor type-22.7.11.300.486
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.484
2j0m4STFocal adhesion kinase 12.7.10.20.483
2o2u738Mitogen-activated protein kinase 102.7.11.240.482
4qnyANPMitogen activated protein kinase, putative/0.482
4h3qANPMitogen-activated protein kinase 12.7.11.240.481
1pmv537Mitogen-activated protein kinase 102.7.11.240.480
4c4f7CEDual specificity protein kinase TTK2.7.12.10.479
2h96893Mitogen-activated protein kinase 82.7.11.240.478
3i60E86Mitogen-activated protein kinase 12.7.11.240.478
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.478
1om1IQACasein kinase II subunit alpha2.7.11.10.477
3t2zFADSulfide-quinone reductase/0.477
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.477
4o0uADNAurora kinase A2.7.11.10.476
2j4z626Aurora kinase A2.7.11.10.475
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.475
3k5uPFQAurora kinase A2.7.11.10.475
2ijmATPFocal adhesion kinase 12.7.10.20.474
3lfqA28Cyclin-dependent kinase 22.7.11.220.472
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.472
5cvhADPCasein kinase II subunit alpha2.7.11.10.472
2pvhP19Casein kinase II subunit alpha2.7.11.10.471
2x1nX1NCyclin-dependent kinase 22.7.11.220.471
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.471
3ormAGSSerine/threonine protein kinase/0.471
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.471
4fv6E57Mitogen-activated protein kinase 12.7.11.240.471
4wsqKSAAP2-associated protein kinase 12.7.11.10.471
1aq1STUCyclin-dependent kinase 22.7.11.220.470
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.470
1pxmCK5Cyclin-dependent kinase 22.7.11.220.469
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.469
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.469
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.469
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.469
3t8oATPRhodopsin kinase/0.468
3zxtACPDeath-associated protein kinase 12.7.11.10.468
4ysjADPCalmodulin-like domain protein kinase/0.468
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.467
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.467
4grb0XGCasein kinase II subunit alpha2.7.11.10.467
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.466
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.466
4dgnLU2Casein kinase II subunit alpha2.7.11.10.466
4lfiGNPCasein kinase II subunit alpha2.7.11.10.466
2pvlP55Casein kinase II subunit alpha2.7.11.10.465
3l8p0CEAngiopoietin-1 receptor2.7.10.10.465
4jbpYPHAurora kinase A2.7.11.10.465
4qmlANPSerine/threonine-protein kinase 242.7.11.10.465
4zohFADPutative oxidoreductase FAD-binding subunit/0.465
1yb5NAPQuinone oxidoreductase1.6.5.50.464
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.464
2j0lANPFocal adhesion kinase 12.7.10.20.463
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.463
2o0uC0MMitogen-activated protein kinase 102.7.11.240.463
4fkv61KCyclin-dependent kinase 22.7.11.220.463
4nifANPMitogen-activated protein kinase 12.7.11.240.463
2zdu446Mitogen-activated protein kinase 102.7.11.240.462
3efwAK8Aurora kinase A2.7.11.10.462
3le62BZCyclin-dependent kinase 22.7.11.220.462
3nszANPCasein kinase II subunit alpha2.7.11.10.462
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.462
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.462
4k33ACPFibroblast growth factor receptor 32.7.10.10.462
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
1oirHDYCyclin-dependent kinase 22.7.11.220.461
2wqeADPAurora kinase A2.7.11.10.461
4jqeANPCasein kinase II subunit alpha2.7.11.10.461
3oroAGSSerine/threonine protein kinase/0.460
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4ek816KCyclin-dependent kinase 22.7.11.220.460
1dawANPCasein kinase II subunit alpha2.7.11.10.459
3t2kFADSulfide-quinone reductase/0.459
4enhFVXCholesterol 24-hydroxylase/0.459
4y93746Tyrosine-protein kinase/0.459
4y95746Tyrosine-protein kinase/0.459
5ap57RODual specificity protein kinase TTK2.7.12.10.459
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.458
1k6pXN3Gag-Pol polyprotein3.4.23.160.457
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.457
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.457
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
3rni21ZCyclin-dependent kinase 22.7.11.220.457
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.457
4gmy0X5Tyrosine-protein kinase JAK2/0.457
3c4zADPRhodopsin kinase/0.456
3fi3JK2Mitogen-activated protein kinase 102.7.11.240.456
3t3c017Gag-Pol polyprotein3.4.23.160.456
3zewSTUEphrin type-B receptor 42.7.10.10.456
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4aqc88ATyrosine-protein kinase JAK2/0.456
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.456
4jboWPHAurora kinase A2.7.11.10.456
4qi5FADCellobiose dehydrogenase/0.456
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.455
2xvdAS6Ephrin type-B receptor 42.7.10.10.455
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.455
3rmf20ZCyclin-dependent kinase 22.7.11.220.455
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.455
4b7dQLECytochrome P450 monooxygenase PikC/0.455
4jr7GNPCasein kinase II subunit alpha2.7.11.10.455
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.455
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.454
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.454
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
5ap7SVEDual specificity protein kinase TTK2.7.12.10.454
2w05FRTCyclin-dependent kinase 22.7.11.220.453
3sz0FADSulfide-quinone reductase/0.453
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.453
4ocvANPAminoglycoside phosphotransferase/0.453
1h1s4SPCyclin-dependent kinase 22.7.11.220.452
2bhhRYUCyclin-dependent kinase 22.7.11.220.452
2hs1017Protease/0.452
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.452
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.452
3bgcLJHGag-Pol polyprotein3.4.23.160.452
3gubGUBDeath-associated protein kinase 12.7.11.10.452
3iok1P6Tyrosine-protein kinase JAK2/0.452
3lltANPProtein serine/threonine kinase-1/0.452
3to6LYS_CMCHistone acetyltransferase ESA1/0.452
4fob0USALK tyrosine kinase receptor2.7.10.10.452
4hvi19STyrosine-protein kinase JAK32.7.10.20.452
4jbiNDPAlcohol dehydrogenase (Zinc)/0.452
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.452
5eg3ACPFibroblast growth factor receptor 2/0.452
1ipeNDPTropinone reductase 21.1.1.2360.451
2ds11CDCyclin-dependent kinase 22.7.11.220.451
3igoANPCalmodulin-domain protein kinase 1, putative/0.451
4hge15VTyrosine-protein kinase JAK2/0.451
4izy1J2Mitogen-activated protein kinase 82.7.11.240.451
4j99ACPFibroblast growth factor receptor 2/0.451
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.451
1xddAAYIntegrin alpha-L/0.450
2bmcMPYAurora kinase A2.7.11.10.450
2y4gTIRTamL/0.450
3lfsA07Cyclin-dependent kinase 22.7.11.220.450
3rk507ZCyclin-dependent kinase 22.7.11.220.450
3syiFADSulfide-quinone reductase/0.450
3zh8C58Protein kinase C iota type2.7.11.130.450
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
4c4g7RODual specificity protein kinase TTK2.7.12.10.450
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.450
1k6cMK1Gag-Pol polyprotein3.4.23.160.449
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.449
3gggNADPrephenate dehydrogenase/0.449
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.449
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.449
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.449
5e92ANPTGF-beta receptor type-22.7.11.300.449
2qnqQN3Gag-Pol polyprotein3.4.23.160.448
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.448
2x4f16XMyosin light chain kinase family member 42.7.11.10.448
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
3oom507Activin receptor type-12.7.11.300.448
3qc9ADPRhodopsin kinase/0.448
4fv9E71Mitogen-activated protein kinase 12.7.11.240.448
4i3zADPCyclin-dependent kinase 22.7.11.220.448
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.447
1e3eNAIAlcohol dehydrogenase 41.1.1.10.447
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
2v7a627Tyrosine-protein kinase ABL12.7.10.20.447
2y3rTIRTamL/0.447
2zjwREFCasein kinase II subunit alpha2.7.11.10.447
3kpkFADSulfide-quinone reductase/0.447
3livE16Protease/0.447
3ortAGSSerine/threonine protein kinase/0.447
3rvg17PTyrosine-protein kinase JAK2/0.447
3t2yFADSulfide-quinone reductase/0.447
4dgo0JWCasein kinase II subunit alpha2.7.11.10.447
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.447
5cnnANPEpidermal growth factor receptor2.7.10.10.447
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.446
2qo9ANPEphrin type-A receptor 32.7.10.10.446
2vttLZDCyclin-dependent kinase 22.7.11.220.446
2w4jADPDeath-associated protein kinase 12.7.11.10.446
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.446
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.446
3sm2478Putative gag-pro-pol polyprotein/0.446
3umoATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.446
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.446
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.446
4f07FADStyrene monooxygenase component 2/0.446
4ic7ANPMitogen-activated protein kinase 72.7.11.240.446
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.446
5av2KMPDeath-associated protein kinase 12.7.11.10.446
5cvfATPCasein kinase II subunit alpha2.7.11.10.446
1e9hINRCyclin-dependent kinase 22.7.11.220.445
1eh4IC1Casein kinase I homolog 12.7.11.10.445
1npvL27Gag-Pol polyprotein3.4.23.160.445
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.445
2y9qANPMitogen-activated protein kinase 12.7.11.240.445
2zbaZBATrichothecene 3-O-acetyltransferase/0.445
3bgbLJGGag-Pol polyprotein3.4.23.160.445
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.445
4c4jX21Dual specificity protein kinase TTK2.7.12.10.445
4eok4SPCyclin-dependent kinase 22.7.11.220.445
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.445
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.445
5l8lADPAurora kinase A2.7.11.10.445
1g5sI17Cyclin-dependent kinase 22.7.11.220.444
1qxoFMNChorismate synthase/0.444
1y0s331Peroxisome proliferator-activated receptor delta/0.444
2j8zNAPQuinone oxidoreductase PIG310.444
2r43G3GGag-Pol polyprotein3.4.23.160.444
2wotZZGTGF-beta receptor type-12.7.11.300.444
3c4xATPRhodopsin kinase/0.444
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444
3pxkPXKFocal adhesion kinase 12.7.10.20.444
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.444
3vt8YI3Vitamin D3 receptor/0.444
1dayGNPCasein kinase II subunit alpha2.7.11.10.443
1m2pHNACasein kinase II subunit alpha2.7.11.10.443
1pkdUCNCyclin-dependent kinase 22.7.11.220.443
2pym1UNGag-Pol polyprotein3.4.23.160.443
2vu3LZECyclin-dependent kinase 22.7.11.220.443
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.443
3my5RFZCyclin-dependent kinase 22.7.11.220.443
3sw719KCyclin-dependent kinase 22.7.11.220.443
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.443
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.443
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.443
1iyzNDPProbable quinone oxidoreductase/0.442
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
2bfyH1NAurora kinase B-A2.7.11.10.442
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.442
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.442
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3c4wATPRhodopsin kinase/0.442
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.442
3gw9VNILanosterol 14-alpha-demethylase/0.442
3tqhNDPQuinone oxidoreductase/0.442
4b8zNAPGDP-L-fucose synthase1.1.1.2710.442
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.442
4j54G52Gag-Pol polyprotein3.4.23.160.442
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
5dosATPAurora kinase A2.7.11.10.442
1i44ACPInsulin receptor2.7.10.10.441
2pvmP29Casein kinase II subunit alpha2.7.11.10.441
2xa4AZ5Tyrosine-protein kinase JAK2/0.441
2y3rTRKTamL/0.441
3at4CCKCasein kinase II subunit alpha2.7.11.10.441
3rk708ZCyclin-dependent kinase 22.7.11.220.441
3slz3TLPutative gag-pro-pol polyprotein/0.441
3vn9ANKDual specificity mitogen-activated protein kinase kinase 62.7.12.20.441
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.441
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.441
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.441
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.441
4q71FADBifunctional protein PutA/0.441
5drdATPAurora kinase A2.7.11.10.441
2nmtNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.440
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.440
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
2zb3NDPProstaglandin reductase 21.3.1.480.440
3g51ANPRibosomal protein S6 kinase alpha-32.7.11.10.440
3h86AP5Adenylate kinase/0.440
3lfnA27Cyclin-dependent kinase 22.7.11.220.440
3nieANPMitogen-activated protein kinase/0.440
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.440
3qyw6PBMitogen-activated protein kinase 12.7.11.240.440
3sheI85MAP kinase-activated protein kinase 32.7.11.10.440
3slkNDPPolyketide synthase extender module 2/0.440
4a6cQG9Gag-Pol polyprotein3.4.23.160.440
4bbe3O4Tyrosine-protein kinase JAK2/0.440
4c4iX20Dual specificity protein kinase TTK2.7.12.10.440
4dgmAGICasein kinase II subunit alpha2.7.11.10.440
4fkr45KCyclin-dependent kinase 22.7.11.220.440
4gyiADPUncharacterized protein/0.440
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4o0wADNAurora kinase A2.7.11.10.440
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.440
5a3bAPRSIR2 family protein/0.440
5dnrATPAurora kinase A2.7.11.10.440