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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3cfoGMPDNA-directed DNA polymerase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3cfoGMPDNA-directed DNA polymerase/1.000
1clqGDPDNA-directed DNA polymerase/0.610
4i9qXG4DNA-directed DNA polymerase/0.601
1waj5GPDNA-directed DNA polymerase/0.590
4khnXG4DNA-directed DNA polymerase/0.555
1ih7GMPDNA-directed DNA polymerase/0.553
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.505
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.497
2xysSY9Soluble acetylcholine receptor/0.497
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.489
4kfqKFQGlutamate receptor ionotropic, NMDA 1/0.489
2v8pCDP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.485
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.483
4a16H34Acetylcholinesterase3.1.1.70.483
4s1iPLPPyridoxal kinase, putative/0.482
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.480
3lpfZ77Beta-glucuronidase3.2.1.310.479
3rvhHQ2Lysine-specific demethylase 4A1.14.110.479
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.478
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.478
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.475
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.474
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.474
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.474
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.474
2v2vV124-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.473
3nxtD2EDihydrofolate reductase1.5.1.30.473
4ajgF07cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.473
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.472
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.472
3c3eFO12-phospho-L-lactate transferase/0.472
2b8jADNClass B acid phosphatase3.1.3.20.471
3bi6396Wee1-like protein kinase2.7.10.20.471
1e2jTHMThymidine kinase/0.470
2v2qNVG4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.470
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.470
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.469
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.469
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.469
1wm1PTBProline iminopeptidase3.4.11.50.468
3d2dRENReticuline oxidase1.21.3.30.467
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.467
4b65NDPL-ornithine N(5)-monooxygenase/0.467
4kfj1R0Dihydrofolate reductase1.5.1.30.467
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.466
3biz61EWee1-like protein kinase2.7.10.20.465
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
1x8b824Wee1-like protein kinase2.7.10.20.464
2rc6FADFerredoxin--NADP reductase/0.464
4bdrKAIGlutamate receptor ionotropic, kainate 2/0.464
4d6qPD2Lysine-specific demethylase 4D1.14.110.464
1isgAGSADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.463
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
3lpgZ78Beta-glucuronidase3.2.1.310.463
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.463
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.463
4to2DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.463
1f3eDPZQueuine tRNA-ribosyltransferase2.4.2.290.462
1ygkRRCPyridoxal kinase2.7.1.350.462
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.462
4rxpDTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.462
1pxgPRFQueuine tRNA-ribosyltransferase2.4.2.290.461
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
4imfSI3N-acetylneuraminate lyase/0.461
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
1qk35GPHypoxanthine-guanine-xanthine phosphoribosyltransferase2.4.2.220.460
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.460
2a4xBLMMitomycin-binding protein/0.460
3cr0809Wee1-like protein kinase2.7.10.20.460
4dxlC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.460
1t57FMNConserved protein/0.459
2v34CTN4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.459
2xk6EQHSerine/threonine-protein kinase Nek22.7.11.10.459
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.459
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.459
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.458
1uwhBAXSerine/threonine-protein kinase B-raf2.7.11.10.458
2olcADPMethylthioribose kinase2.7.1.1000.458
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.458
3l7gM44Xaa-Pro dipeptidase3.4.13.90.458
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
1d6w00RProthrombin3.4.21.50.457
1mczRMNBenzoylformate decarboxylase4.1.1.70.457
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.457
2ieaTDPPyruvate dehydrogenase E1 component1.2.4.10.457
3arvSAUChitinase A/0.457
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
2ea4F79Methionine aminopeptidase 2/0.456
2in6839Wee1-like protein kinase2.7.10.20.456
2zevIPEGeranylgeranyl pyrophosphate synthase/0.456
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4diqPD2Ribosomal oxygenase 1/0.456
1mvsDTMDihydrofolate reductase1.5.1.30.455
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3oafOAGDihydrofolate reductase1.5.1.30.455
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.455
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.455
1lb9DNQGlutamate receptor 2/0.454
1rxjBNIStreptavidin/0.454
1yw7A41Methionine aminopeptidase 2/0.454
3fhxPLPPyridoxal kinase2.7.1.350.454
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3o9pMHIPeriplasmic murein peptide-binding protein/0.454
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.453
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3nxrD2DDihydrofolate reductase1.5.1.30.453
3p3zP3ZPutative cytochrome P450/0.453
4bis8HQLysine-specific demethylase 4A1.14.110.453
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.453
1dr4HBIDihydrofolate reductase1.5.1.30.452
1oe0TTPDeoxynucleoside kinase/0.452
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2qcxPF1Aminopyrimidine aminohydrolase/0.452
3jusBCDLanosterol 14-alpha demethylase1.14.13.700.452
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.452
3pqbVGPPutative oxidoreductase/0.452
3ufl508Beta-secretase 13.4.23.460.452
1ftlDNQGlutamate receptor 2/0.451
1lbbKAIGlutamate receptor 2/0.451
1ot3THMDeoxynucleoside kinase/0.451
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.451
2e94364Geranylgeranyl pyrophosphate synthase/0.451
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.451
2qx7NAPEugenol synthase 11.1.1.3180.451
3b5iSAHIndole-3-acetate O-methyltransferase 1/0.451
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.451
3h0wN8MS-adenosylmethionine decarboxylase proenzyme4.1.1.500.451
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.451
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.450
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.450
3apwDP0Alpha-1-acid glycoprotein 2/0.450
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
5erm210Fusicoccadiene synthase4.2.3.430.450
5fe112QHistone acetyltransferase KAT2B2.3.1.480.450
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.449
3lfzADPUncharacterized protein MJ1225/0.449
3ojxFMNNADPH--cytochrome P450 reductase/0.449
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.449
4ec3RENReticuline oxidase1.21.3.30.449
1e2kTMCThymidine kinase/0.448
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.448
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
1zisINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
2b82ADNClass B acid phosphatase3.1.3.20.448
2v0uFMNNPH1-1/0.448
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3koyZ97D-ornithine 4,5-aminomutase subunit beta/0.448
3ojiPYVAbscisic acid receptor PYL3/0.448
3u8dU8DPhospholipase A2, membrane associated/0.448
4gh10WXQueuine tRNA-ribosyltransferase2.4.2.290.448
4jlj1NMDeoxycytidine kinase2.7.1.740.448
4kd79DRDihydrofolate reductase1.5.1.30.448
4lcw1VYMajor histocompatibility complex class I-related gene protein/0.448
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.447
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
4hfp15UProthrombin3.4.21.50.447
1ozqPRFQueuine tRNA-ribosyltransferase2.4.2.290.446
1w7h3IPMitogen-activated protein kinase 14/0.446
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
2z1wBDIQueuine tRNA-ribosyltransferase2.4.2.290.446
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.446
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4h2iA125'-nucleotidase3.1.3.50.446
4ivqI43Thymidine kinase/0.446
4nwiCTN7-methylguanosine phosphate-specific 5'-nucleotidase/0.446
3uzcT4EAdenosine receptor A2a/0.446
1ao8MTXDihydrofolate reductase1.5.1.30.445
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.445
1xmmM7Gm7GpppX diphosphatase3.6.1.590.445
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.445
2g1a5HGClass B acid phosphatase3.1.3.20.445
2vd7PD2Lysine-specific demethylase 4A1.14.110.445
2z2w770Wee1-like protein kinase2.7.10.20.445
2zulSAMProbable ribosomal RNA small subunit methyltransferase/0.445
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.445
3lfeZ84Mitogen-activated protein kinase 14/0.445
3nhlYTRRibosyldihydronicotinamide dehydrogenase [quinone]/0.445
4gh30EVQueuine tRNA-ribosyltransferase2.4.2.290.445
4jhz1KVBeta-glucuronidase3.2.1.310.445
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
2ycxP32Beta-1 adrenergic receptor/0.445
1dx6GNTAcetylcholinesterase3.1.1.70.444
1obnASVIsopenicillin N synthase1.21.3.10.444
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
2fjm073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.444
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2ga2A19Methionine aminopeptidase 2/0.444
2hxzH7JCathepsin S3.4.22.270.444
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
3cqeP91Wee1-like protein kinase2.7.10.20.444
3i2834NBifunctional epoxide hydrolase 23.3.2.100.444
4kxjP34Nucleoprotein/0.444
4pjjADPUnconventional myosin-VI/0.444
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2cleF6FTryptophan synthase alpha chain/0.443
2r6jNDPEugenol synthase 11.1.1.3180.443
3f90FMNFlavodoxin/0.443
3k4551PDihydrofolate reductase1.5.1.30.443
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.443
1g7uPEP2-dehydro-3-deoxyphosphooctonate aldolase2.5.1.550.442
1nd52BFProstatic acid phosphatase3.1.3.20.442
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.442
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.442
2eg5SAH7-methylxanthosine synthase 1/0.442
2oc4IMHPurine nucleoside phosphorylase2.4.2.10.442
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3e3uNVCPeptide deformylase3.5.1.880.442
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.442
4ddrMMVDihydrofolate reductase1.5.1.30.442
1oj4CDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.441
2a5c8DAAvidin/0.441
2mm3GCHGastrotropin/0.441
2ojg19AMitogen-activated protein kinase 12.7.11.240.441
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.441
2v58LZJBiotin carboxylase6.3.4.140.441
3bldPRFQueuine tRNA-ribosyltransferase2.4.2.290.441
3dgeADPSensor histidine kinase/0.441
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3s8pSAMHistone-lysine N-methyltransferase KMT5B2.1.1.430.441
3tneRITCandidapepsin-13.4.23.240.441
3wd2A1LChitinase B3.2.1.140.441
4gutFADLysine-specific histone demethylase 1B10.441
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.441
5e9eANPMyosin heavy chain kinase A2.7.11.70.441
1diuBDMDihydrofolate reductase1.5.1.30.440
1isjNMNADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.440
1mabADPATP synthase subunit beta, mitochondrial3.6.3.140.440
1p72THMThymidine kinase/0.440
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1sjwNGVNogalonic acid methyl ester cyclase/0.440
1uk1FRQPoly [ADP-ribose] polymerase 12.4.2.300.440
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.440
2ohl2AQBeta-secretase 13.4.23.460.440
2w3aTOPDihydrofolate reductase1.5.1.30.440
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
2zjuIM4Acetylcholine-binding protein/0.440
3fhxPXLPyridoxal kinase2.7.1.350.440
3klbFMNUncharacterized protein/0.440
3owaFADAcyl-CoA dehydrogenase/0.440
4bftZVTPantothenate kinase2.7.1.330.440
4g2wNI0cGMP-specific 3',5'-cyclic phosphodiesterase/0.440
4gd40WSLysine-specific demethylase 4A1.14.110.440
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.440
4y7cFMNNADPH--cytochrome P450 reductase/0.440
3uzaT4GAdenosine receptor A2a/0.440