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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3cd2MTXDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3cd2MTXDihydrofolate reductase1.5.1.31.000
2fzhDH1Dihydrofolate reductase1.5.1.30.724
1cd2FOLDihydrofolate reductase1.5.1.30.627
3td8D2RDihydrofolate reductase1.5.1.30.611
1ly3COGDihydrofolate reductase1.5.1.30.606
2fziDH3Dihydrofolate reductase1.5.1.30.590
1vj3TABDihydrofolate reductase1.5.1.30.589
3cseN22Uncharacterized protein/0.582
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.567
4ixeIXEDihydrofolate reductase1.5.1.30.567
1dajMOTDihydrofolate reductase1.5.1.30.566
2cd2FOLDihydrofolate reductase1.5.1.30.559
3qly55VUncharacterized protein/0.557
4h9753SDihydrofolate reductase1.5.1.30.557
4cd2FOLDihydrofolate reductase1.5.1.30.556
3eel53TUncharacterized protein/0.554
1ly4COQDihydrofolate reductase1.5.1.30.552
4ixfIXFDihydrofolate reductase1.5.1.30.549
3eek53SUncharacterized protein/0.547
4h9814QUncharacterized protein/0.544
3dfrMTXDihydrofolate reductase1.5.1.30.543
1e26GPBDihydrofolate reductase1.5.1.30.541
3qlxQLRUncharacterized protein/0.541
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.540
3qlwN22Dihydrofolate reductase1.5.1.30.540
3ia4MTXDihydrofolate reductase/0.534
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.533
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.533
4h9506UDihydrofolate reductase1.5.1.30.533
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.532
3qlzQLZUncharacterized protein/0.532
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.531
1rx3MTXDihydrofolate reductase1.5.1.30.530
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.524
3eej53RUncharacterized protein/0.521
4h9614QDihydrofolate reductase1.5.1.30.521
3eem53VUncharacterized protein/0.517
1aoeGW3Dihydrofolate reductase1.5.1.30.516
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.514
1m7aMQUDihydrofolate reductase1.5.1.30.512
4dp3MMVBifunctional dihydrofolate reductase-thymidylate synthase/0.512
3dauMTXDihydrofolate reductase1.5.1.30.505
2zzaFOLDihydrofolate reductase/0.503
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.503
4dphP65Bifunctional dihydrofolate reductase-thymidylate synthase/0.496
4xe606UDihydrofolate reductase1.5.1.30.496
3drcMTXDihydrofolate reductase1.5.1.30.494
1df7MTXDihydrofolate reductase1.5.1.30.493
1dg5TOPDihydrofolate reductase1.5.1.30.492
2w3vTOPDihydrofolate reductase/0.491
3ix9MTXDihydrofolate reductase1.5.1.30.491
3qlrQLRDihydrofolate reductase1.5.1.30.491
4nx6FOLDihydrofolate reductase1.5.1.30.490
1draMTXDihydrofolate reductase1.5.1.30.489
3frdDHFDihydrofolate reductase1.5.1.30.489
4nx7FOLDihydrofolate reductase1.5.1.30.485
3tq9MTXDihydrofolate reductase/0.484
4x5gFOLDihydrofolate reductase1.5.1.30.482
1diuBDMDihydrofolate reductase1.5.1.30.481
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.481
3datMTXDihydrofolate reductase/0.479
3tqbFOLDihydrofolate reductase/0.478
1drbMTXDihydrofolate reductase1.5.1.30.477
3och2MXDihydrofolate reductase1.5.1.30.476
4g8zTOPDihydrofolate reductase1.5.1.30.476
1jolFFODihydrofolate reductase1.5.1.30.475
1tdrMTXDihydrofolate reductase1.5.1.30.475
3ghvGHCDihydrofolate reductase1.5.1.30.475
3d80Q22Dihydrofolate reductase1.5.1.30.474
3qls55VDihydrofolate reductase1.5.1.30.474
3sruQ26Dihydrofolate reductase1.5.1.30.474
1hfqMOTDihydrofolate reductase1.5.1.30.473
3fy9XCFDihydrofolate reductase1.5.1.30.473
5hi6MTXDihydrofolate reductase/0.473
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.472
4fgh0U6Dihydrofolate reductase1.5.1.30.471
4fgg0U5Dihydrofolate reductase1.5.1.30.470
4ixgIXGDihydrofolate reductase1.5.1.30.470
1kmsLIHDihydrofolate reductase1.5.1.30.468
4m6l21VDihydrofolate reductase1.5.1.30.467
1ddsMTXDihydrofolate reductase1.5.1.30.466
3clbTMQBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.464
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.463
4ddrMMVDihydrofolate reductase1.5.1.30.463
3frfXCFDihydrofolate reductase1.5.1.30.462
7dfrFOLDihydrofolate reductase1.5.1.30.462
3fl8RARDihydrofolate reductase/0.461
3sa27DRDihydrofolate reductase/0.461
3srqQ19Dihydrofolate reductase1.5.1.30.461
4elb34SDihydrofolate reductase/0.461
4m2xTMQDihydrofolate reductase1.5.1.30.461
1errRALEstrogen receptor/0.460
1tduCB3Thymidylate synthase/0.459
3jwcEKBDihydrofolate reductase/0.459
1hfpMOTDihydrofolate reductase1.5.1.30.458
1s3yTQTDihydrofolate reductase1.5.1.30.458
2hw2RFPRifampin ADP-ribosyl transferase/0.458
1ohkCOPDihydrofolate reductase1.5.1.30.457
3fywXCFDihydrofolate reductase1.5.1.30.456
4dfrMTXDihydrofolate reductase1.5.1.30.456
3jw5TOPDihydrofolate reductase/0.455
3l3rOAGDihydrofolate reductase1.5.1.30.455
4p66MTXDihydrofolate reductase/0.455
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.454
3m08RARDihydrofolate reductase1.5.1.30.454
2drcMTXDihydrofolate reductase1.5.1.30.453
2qk8MTXDihydrofolate reductase/0.453
4elh53IDihydrofolate reductase/0.453
4j6cSTRCytochrome P450 monooxygenase/0.453
5a27MYAGlycylpeptide N-tetradecanoyltransferase/0.453
1rf7DHFDihydrofolate reductase1.5.1.30.452
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.452
4ele31IDihydrofolate reductase/0.452
1disBDMDihydrofolate reductase1.5.1.30.451
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.451
1rg7MTXDihydrofolate reductase1.5.1.30.450
2fzjDH3Dihydrofolate reductase1.5.1.30.450
3jwm5WBDihydrofolate reductase/0.450
4jbtASDCytochrome P450 monooxygenase/0.450
4kjjFOLDihydrofolate reductase1.5.1.30.450
1zg32HIIsoflavone 4'-O-methyltransferase/0.449
3ghwGHWDihydrofolate reductase1.5.1.30.449
4a95NHWGlycylpeptide N-tetradecanoyltransferase/0.449
4b11NHWGlycylpeptide N-tetradecanoyltransferase/0.449
4j6dTESCytochrome P450 monooxygenase/0.449
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
4elf35IDihydrofolate reductase/0.448
3abaFLICytochrome P450/0.447
3ua506XCytochrome P450 2B61.14.130.447
3freTOPDihydrofolate reductase1.5.1.30.446
4bbhNHWGlycylpeptide N-tetradecanoyltransferase/0.446
1u72MTXDihydrofolate reductase1.5.1.30.445
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.445
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.445
4kak06UDihydrofolate reductase1.5.1.30.445
3srwQ27Dihydrofolate reductase1.5.1.30.444
4c2zMYAGlycylpeptide N-tetradecanoyltransferase 1/0.444
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.443
3sa16DRDihydrofolate reductase/0.443
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
2wsaMYAGlycylpeptide N-tetradecanoyltransferase/0.442
3gi2GHWDihydrofolate reductase1.5.1.30.442
4kfj1R0Dihydrofolate reductase1.5.1.30.442
4ucnMYAGlycylpeptide N-tetradecanoyltransferase/0.442
1dyjDDFDihydrofolate reductase1.5.1.30.441
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.441
1f4gTP4Thymidylate synthase/0.440
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
2yncYNCGlycylpeptide N-tetradecanoyltransferase/0.440
4j6bPLOCytochrome P450 monooxygenase/0.440