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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3cbsR12Cellular retinoic acid-binding protein 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3cbsR12Cellular retinoic acid-binding protein 2/1.000
2g78REACellular retinoic acid-binding protein 2/0.636
2cbsR13Cellular retinoic acid-binding protein 2/0.617
1cbsREACellular retinoic acid-binding protein 2/0.615
1cbrREACellular retinoic acid-binding protein 1/0.591
1cbqRE9Cellular retinoic acid-binding protein 2/0.570
3cwkREACellular retinoic acid-binding protein 2/0.505
2cbrA80Cellular retinoic acid-binding protein 1/0.500
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.472
3kpkFADSulfide-quinone reductase/0.467
3hk1B64Fatty acid-binding protein, adipocyte/0.466
3vt7VDXVitamin D3 receptor/0.463
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.461
1kzjCB3Thymidylate synthase/0.460
4nmdFDABifunctional protein PutA/0.460
1w2xRCPAcetyl-CoA carboxylase/0.457
2om9AJAPeroxisome proliferator-activated receptor gamma/0.457
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.457
3vrwYS5Vitamin D3 receptor/0.456
4q71FADBifunctional protein PutA/0.456
3vt9YI4Vitamin D3 receptor/0.455
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.455
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.454
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.453
2fr3REACellular retinoic acid-binding protein 2/0.453
3iaeD7KBenzaldehyde lyase/0.452
1iyzNDPProbable quinone oxidoreductase/0.451
1kkq471Peroxisome proliferator-activated receptor alpha/0.451
4nb6444Nuclear receptor ROR-gamma/0.451
3syiFADSulfide-quinone reductase/0.450
3sz0FADSulfide-quinone reductase/0.450
2ath3EAPeroxisome proliferator-activated receptor gamma/0.449
1s19MC9Vitamin D3 receptor/0.448
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.448
3a1nNADNDP-sugar epimerase/0.448
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.448
3jynNDPQuinone oxidoreductase/0.447
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.446
2q4bNAPUncharacterized protein At5g02240/0.446
3vcyUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.446
2ou2ACOHistone acetyltransferase KAT5/0.445
3h0aD30Peroxisome proliferator-activated receptor gamma/0.445
2o4rVD5Vitamin D3 receptor/0.444
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.444
2q61SF1Peroxisome proliferator-activated receptor gamma/0.443
3v9y24LPeroxisome proliferator-activated receptor gamma/0.443
4qe6JN3Bile acid receptor/0.443
2cduFADNADH oxidase/0.442
3adaNADSubunit alpha of sarocosine oxidase/0.442
3b20NADGlyceraldehyde-3-phosphate dehydrogenase/0.442
3bejMUFBile acid receptor/0.442
3qlrNDPDihydrofolate reductase1.5.1.30.442
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1fm9570Peroxisome proliferator-activated receptor gamma/0.441
3h0sB38Acetyl-CoA carboxylase/0.441
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
1dg8NDPDihydrofolate reductase1.5.1.30.440
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.440
2cig1DGDihydrofolate reductase1.5.1.30.440
3gc9B45Mitogen-activated protein kinase 112.7.11.240.440
3hjaNADGlyceraldehyde-3-phosphate dehydrogenase/0.440
3l0lHC3Nuclear receptor ROR-gamma/0.440
3vspEK8Peroxisome proliferator-activated receptor gamma/0.440
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.440
4qi5FADCellobiose dehydrogenase/0.440