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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3c50ADPRhodopsin kinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3c50ADPRhodopsin kinase/1.000
3c4zADPRhodopsin kinase/0.616
3c4wATPRhodopsin kinase/0.594
3qc9ADPRhodopsin kinase/0.555
5dt3ATPAurora kinase A2.7.11.10.553
4l9i8PRRhodopsin kinase/0.548
5drdATPAurora kinase A2.7.11.10.541
3t8oATPRhodopsin kinase/0.527
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.525
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.524
4deeADPAurora kinase A2.7.11.10.524
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.522
5dt4ATPAurora kinase A2.7.11.10.521
2acxANPG protein-coupled receptor kinase 62.7.11.160.520
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.519
3nizADPCdc2-like CDK2/CDC28 like protein kinase/0.516
3nynSGVG protein-coupled receptor kinase 62.7.11.160.516
2x1nX1NCyclin-dependent kinase 22.7.11.220.515
3a7jADPSerine/threonine-protein kinase 242.7.11.10.513
1ir3ANPInsulin receptor2.7.10.10.511
1ol5ADPAurora kinase A2.7.11.10.510
1u54ACPActivated CDC42 kinase 1/0.508
4k33ACPFibroblast growth factor receptor 32.7.10.10.506
1ol7ADPAurora kinase A2.7.11.10.503
2uzlC94Cyclin-dependent kinase 22.7.11.220.502
4zseANPEpidermal growth factor receptor2.7.10.10.500
4gu94GUFocal adhesion kinase 12.7.10.20.499
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.497
1mq4ADPAurora kinase A2.7.11.10.496
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.496
4jr7GNPCasein kinase II subunit alpha2.7.11.10.496
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.495
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.495
3orkAGSSerine/threonine protein kinase/0.495
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.493
5dn3ATPAurora kinase A2.7.11.10.493
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.491
4xlvACPInsulin receptor2.7.10.10.490
2dwbANPAurora kinase A2.7.11.10.489
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.489
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.488
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.488
2cchATPCyclin-dependent kinase 22.7.11.220.487
2ckeIQUDeath-associated protein kinase 2/0.487
4ic7ANPMitogen-activated protein kinase 72.7.11.240.487
1csnATPCasein kinase I homolog 12.7.11.10.486
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.486
3bu5ATPInsulin receptor2.7.10.10.486
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.486
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.485
5dnrATPAurora kinase A2.7.11.10.484
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.483
2izrBRKCasein kinase I isoform gamma-32.7.11.10.483
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.483
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.483
1jstATPCyclin-dependent kinase 22.7.11.220.481
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.481
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.481
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.480
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.480
4k8aK8AFocal adhesion kinase 12.7.10.20.480
3gu6ADPDeath-associated protein kinase 12.7.11.10.479
4loqSB4Mitogen-activated protein kinase 14/0.479
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.478
4wboANWRhodopsin kinase/0.478
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.477
3k5uPFQAurora kinase A2.7.11.10.477
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.476
2izsBRQCasein kinase I isoform gamma-32.7.11.10.476
1dawANPCasein kinase II subunit alpha2.7.11.10.475
2ozoANPTyrosine-protein kinase ZAP-702.7.10.20.475
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.475
2c6tDT5Cyclin-dependent kinase 22.7.11.220.474
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.474
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.474
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.474
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.474
3zxtACPDeath-associated protein kinase 12.7.11.10.473
4bbe3O4Tyrosine-protein kinase JAK2/0.473
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.473
4fi1ATPCasein kinase II subunit alpha2.7.11.10.473
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.472
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.472
4lfiGNPCasein kinase II subunit alpha2.7.11.10.472
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.471
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.470
3nszANPCasein kinase II subunit alpha2.7.11.10.470
3w32W32Epidermal growth factor receptor2.7.10.10.470
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.470
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.470
4o0wADNAurora kinase A2.7.11.10.470
2wihP48Cyclin-dependent kinase 22.7.11.220.469
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
4mwhATPCasein kinase II subunit alpha2.7.11.10.469
2hog710Serine/threonine-protein kinase Chk12.7.11.10.468
2xikJ60Serine/threonine-protein kinase 252.7.11.10.468
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.468
4utdACPAurora kinase A2.7.11.10.468
1v0pPVBCell division control protein 2 homolog2.7.11.220.467
2hw1ANPKetohexokinase/0.467
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.467
3oriAGSSerine/threonine protein kinase/0.467
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.467
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.466
2wpa889Cyclin-dependent kinase 22.7.11.220.466
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.466
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.466
4hnf16WCasein kinase I isoform delta2.7.11.10.466
5e8wSTUTGF-beta receptor type-12.7.11.300.466
2etm7PYFocal adhesion kinase 12.7.10.20.465
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.465
3qaiXNNKetohexokinase/0.465
4kbk1QGCasein kinase I isoform delta2.7.11.10.465
5auvAGIDeath-associated protein kinase 12.7.11.10.465
2v7a627Tyrosine-protein kinase ABL12.7.10.20.464
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.464
3mdmFJZCholesterol 24-hydroxylase/0.464
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.464
4jia1K3Tyrosine-protein kinase JAK2/0.464
1dayGNPCasein kinase II subunit alpha2.7.11.10.463
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.463
2w4kADPDeath-associated protein kinase 12.7.11.10.463
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
4jrnANPRhoptry kinase family protein/0.463
4xumIMNPeroxisome proliferator-activated receptor gamma/0.463
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.463
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.462
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
4eomATPCyclin-dependent kinase 22.7.11.220.462
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.462
5cvhADPCasein kinase II subunit alpha2.7.11.10.462
1h1r6CPCyclin-dependent kinase 22.7.11.220.461
2qocANPEphrin type-A receptor 32.7.10.10.461
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.461
4e4m0NHTyrosine-protein kinase JAK2/0.461
4fuxE75Mitogen-activated protein kinase 12.7.11.240.461
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.461
5auwQUEDeath-associated protein kinase 12.7.11.10.461
2henADPEphrin type-B receptor 22.7.10.10.460
2qoqANPEphrin type-A receptor 32.7.10.10.460
3i81EBIInsulin-like growth factor 1 receptor2.7.10.10.460
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.460
4cfnJYMCyclin-dependent kinase 22.7.11.220.460
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
3qwkX62Cyclin-dependent kinase 22.7.11.220.459
4b99R4LMitogen-activated protein kinase 72.7.11.240.459
4g170VNCasein kinase I isoform gamma-32.7.11.10.459
4g3pUD1Bifunctional protein GlmU/0.459
4qmlANPSerine/threonine-protein kinase 242.7.11.10.459
4yuqKS1Calmodulin-like domain protein kinase/0.459
1gy3ATPCyclin-dependent kinase 22.7.11.220.458
2w1fL0FAurora kinase A2.7.11.10.458
2wqeADPAurora kinase A2.7.11.10.458
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.458
1lp4ANPCasein kinase II subunit alpha2.7.11.10.457
2iw94SPCyclin-dependent kinase 22.7.11.220.457
4btjADPTau-tubulin kinase 12.7.11.10.457
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.457
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
1pmn984Mitogen-activated protein kinase 102.7.11.240.456
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.456
2c5nCK8Cyclin-dependent kinase 22.7.11.220.456
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.456
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.456
3ddpRC8Cyclin-dependent kinase 22.7.11.220.456
4oavACP2-5A-dependent ribonuclease3.1.260.456
5e92ANPTGF-beta receptor type-22.7.11.300.456
1aq1STUCyclin-dependent kinase 22.7.11.220.455
2btsU32Cyclin-dependent kinase 22.7.11.220.455
2w1gL0GAurora kinase A2.7.11.10.455
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.455
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.455
3s2pPMUCyclin-dependent kinase 22.7.11.220.455
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
5hs1VORLanosterol 14-alpha demethylase/0.455
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.454
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.454
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.454
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.454
2fumMIXSerine/threonine-protein kinase PknB2.7.11.10.454
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.454
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.454
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.453
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4b0gVEKAurora kinase A2.7.11.10.453
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.453
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.453
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
1u4dDBQActivated CDC42 kinase 1/0.452
4bcpT3CCyclin-dependent kinase 22.7.11.220.452
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.452
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.452
4g160VMCasein kinase I isoform gamma-32.7.11.10.452
1p4fDRGDeath-associated protein kinase 12.7.11.10.451
2bkzSBCCyclin-dependent kinase 22.7.11.220.451
2eufLQQCyclin-dependent kinase 62.7.11.220.451
2j0m4STFocal adhesion kinase 12.7.10.20.451
2xngA0HAurora kinase A2.7.11.10.451
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.451
4o0sADNAurora kinase A2.7.11.10.451
5dr2ATPAurora kinase A2.7.11.10.451
1b39ATPCyclin-dependent kinase 22.7.11.220.450
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.450
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.450
2pvhP19Casein kinase II subunit alpha2.7.11.10.450
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
3frqERYErythromycin resistance repressor protein/0.450
3miaANPCyclin-dependent kinase 92.7.11.220.450
4enhFVXCholesterol 24-hydroxylase/0.450
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.450
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.450
2dcnADP2-keto-3-deoxy-gluconate kinase/0.449
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.449
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4hvh19RTyrosine-protein kinase JAK32.7.10.20.449
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.449
4kb81QNCasein kinase I isoform delta2.7.11.10.449
1h1s4SPCyclin-dependent kinase 22.7.11.220.448
1wvxBD4Death-associated protein kinase 12.7.11.10.448
2qo9ANPEphrin type-A receptor 32.7.10.10.448
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.448
3a60STURibosomal protein S6 kinase beta-12.7.11.10.448
3c1y2BADNA integrity scanning protein DisA/0.448
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.448
3nwxKVSGag-Pol polyprotein3.4.23.160.448
3p8jFMNPentaerythritol tetranitrate reductase/0.448
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.448
3zh8C58Protein kinase C iota type2.7.11.130.448
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.448
4lx9ACON-alpha-acetyltransferase2.3.10.448
1bygSTUTyrosine-protein kinase CSK/0.447
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.447
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.447
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.447
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.447
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.447
4jboWPHAurora kinase A2.7.11.10.447
4lopSB4Mitogen-activated protein kinase 14/0.447
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
1fvv107Cyclin-dependent kinase 22.7.11.220.446
2c6hPXICytochrome P450 monooxygenase PikC/0.446
2gjnFMNNitronate monooxygenase1.13.12.160.446
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.446
3ocpCMPcGMP-dependent protein kinase 12.7.11.120.446
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.446
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.446
4ix5ANPUncharacterized protein/0.446
4xj3GTPCyclic GMP-AMP synthase/0.446
2bhhRYUCyclin-dependent kinase 22.7.11.220.445
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.445
2uzbC75Cyclin-dependent kinase 22.7.11.220.445
3q92XNBKetohexokinase/0.445
3w16P9JAurora kinase A2.7.11.10.445
4bcoT6QCyclin-dependent kinase 22.7.11.220.445
4i22IREEpidermal growth factor receptor2.7.10.10.445
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.445
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.445
5auxKMPDeath-associated protein kinase 12.7.11.10.445
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.444
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.444
3gu5ANPDeath-associated protein kinase 12.7.11.10.444
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.444
3zep1NXTyrosine-protein kinase JAK32.7.10.20.444
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4gt3ATPMitogen-activated protein kinase 12.7.11.240.444
1y91CT9Cyclin-dependent kinase 22.7.11.220.443
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
2oj9BMIInsulin-like growth factor 1 receptor2.7.10.10.443
2py3ACPFibroblast growth factor receptor 2/0.443
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.443
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.443
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.443
3ml9ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.443
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.443
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.443
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
1m2rMNYCasein kinase II subunit alpha2.7.11.10.442
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.442
2pzpACPFibroblast growth factor receptor 2/0.442
3nc9TR3Ketohexokinase/0.442
3qa2XNAKetohexokinase/0.442
3u9eCOALmo1369 protein/0.442
4yaoFMNNADPH--cytochrome P450 reductase/0.442
1unlRRCCyclin-dependent-like kinase 52.7.11.10.441
1v0oINRCell division control protein 2 homolog2.7.11.220.441
2jedLG8Protein kinase C theta type2.7.11.130.441
2oji33AMitogen-activated protein kinase 12.7.11.240.441
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3gubGUBDeath-associated protein kinase 12.7.11.10.441
3hkoANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands/0.441
3lfqA28Cyclin-dependent kinase 22.7.11.220.441
3lq5SLQCyclin-dependent kinase 92.7.11.220.441
3qyw6PBMitogen-activated protein kinase 12.7.11.240.441
4erwSTUCyclin-dependent kinase 22.7.11.220.441
4n57ADPAPH(2'')-Id/0.441
4o701QKBromodomain-containing protein 4/0.441
5av2KMPDeath-associated protein kinase 12.7.11.10.441
5dr9SKEAurora kinase A2.7.11.10.441
1gih1PUCyclin-dependent kinase 22.7.11.220.440
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.440
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.440
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.440
2yn8STUEphrin type-B receptor 42.7.10.10.440
3bhtMFRCyclin-dependent kinase 22.7.11.220.440
3gu83GUDeath-associated protein kinase 12.7.11.10.440
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.440
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.440
4eor4SPCyclin-dependent kinase 22.7.11.220.440
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.440
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.440