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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3c1xCKKHepatocyte growth factor receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3c1xCKKHepatocyte growth factor receptor2.7.10.11.000
4gg70J8Hepatocyte growth factor receptor2.7.10.10.568
3a4pDFQHepatocyte growth factor receptor2.7.10.10.545
2wkmPFYHepatocyte growth factor receptor2.7.10.10.540
3ctj320Hepatocyte growth factor receptor2.7.10.10.537
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.532
3e5aVX6Aurora kinase A2.7.11.10.528
2wgjVGHHepatocyte growth factor receptor2.7.10.10.523
3cth319Hepatocyte growth factor receptor2.7.10.10.523
4gg50J3Hepatocyte growth factor receptor2.7.10.10.521
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.520
4aoi4K0Hepatocyte growth factor receptor2.7.10.10.513
3iw4LW4Protein kinase C alpha type2.7.11.130.508
2jedLG8Protein kinase C theta type2.7.11.130.507
4b8mVX6Aurora kinase B-A2.7.11.10.507
4jbtASDCytochrome P450 monooxygenase/0.507
4iaq2GM5-hydroxytryptamine receptor 1B/0.506
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.504
4deg0JJHepatocyte growth factor receptor2.7.10.10.503
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.501
3zkyWT4Isopenicillin N synthase1.21.3.10.501
4af3VX6Aurora kinase B2.7.11.10.499
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.496
2in6839Wee1-like protein kinase2.7.10.20.494
4iarERM5-hydroxytryptamine receptor 1B/0.493
4j6cSTRCytochrome P450 monooxygenase/0.493
1hfqMOTDihydrofolate reductase1.5.1.30.492
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.492
4hni16WCasein kinase I isoform epsilon2.7.11.10.492
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.490
1zg32HIIsoflavone 4'-O-methyltransferase/0.490
3zxzKRWHepatocyte growth factor receptor2.7.10.10.490
4ap7F47Hepatocyte growth factor receptor2.7.10.10.489
5k2aZMAAdenosine receptor A2a/0.489
2punACPMethylthioribose kinase2.7.1.1000.488
4fnyI3KALK tyrosine kinase receptor2.7.10.10.488
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.487
3l0lHC3Nuclear receptor ROR-gamma/0.487
3p3zP3ZPutative cytochrome P450/0.487
3zbx6XEHepatocyte growth factor receptor2.7.10.10.487
4h9506UDihydrofolate reductase1.5.1.30.487
5h8tRTLRetinol-binding protein 1/0.487
1pkfEPDEpothilone C/D epoxidase1.140.486
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.486
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.486
3kytHC2Nuclear receptor ROR-gamma/0.485
3reyXACAdenosine receptor A2a/0.485
1blzACVIsopenicillin N synthase1.21.3.10.484
4c2wANPAurora kinase B-A2.7.11.10.484
4nmbFADBifunctional protein PutA/0.484
3bfa9ODOdorant binding protein ASP1/0.483
4iteTEYVitamin D3 receptor/0.483
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.483
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.482
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.482
1kl2FONSerine hydroxymethyltransferase/0.481
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.481
2q9fC3SCholesterol 24-hydroxylase/0.481
4j6dTESCytochrome P450 monooxygenase/0.481
4k9yK9YFocal adhesion kinase 12.7.10.20.481
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.480
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.479
2io6330Wee1-like protein kinase2.7.10.20.479
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.479
3vg9ZMAAdenosine receptor A2a/0.479
1xuoLA1Integrin alpha-L/0.478
3f82353Hepatocyte growth factor receptor2.7.10.10.478
3nj0PYVAbscisic acid receptor PYL2/0.478
4eevL1XHepatocyte growth factor receptor2.7.10.10.478
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.477
1bk0ACVIsopenicillin N synthase1.21.3.10.476
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.476
3tm5SFGUncharacterized protein/0.476
4a99MIYTetX family tetracycline inactivation enzyme/0.476
4at5MUJBDNF/NT-3 growth factors receptor2.7.10.10.476
4klnAGSTransitional endoplasmic reticulum ATPase3.6.4.60.476
1pd9CO4Dihydrofolate reductase1.5.1.30.475
2vn0TDZCytochrome P450 2C8/0.475
3qly55VUncharacterized protein/0.475
4equG6ISerine/threonine-protein kinase 102.7.11.10.475
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.475
1ia1TQ3Dihydrofolate reductase1.5.1.30.474
1ml6GBXGlutathione S-transferase A22.5.1.180.474
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.474
3p6oETGCamphor 5-monooxygenase1.14.15.10.474
3t8xT8XT-cell surface glycoprotein CD1b/0.474
2vcmM11Isopenicillin N synthase1.21.3.10.473
2z2w770Wee1-like protein kinase2.7.10.20.473
4kwi1TJReductase homolog/0.473
3pwhZMAAdenosine receptor A2a/0.473
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.472
2hb7O1CVitamin D3 receptor/0.472
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.472
2ph5NADHomospermidine synthase/0.472
2xvv9DNSerum albumin/0.472
3d74NBBPheromone-binding protein ASP1/0.472
4jqh1MFAlr2278 protein/0.472
1cqp803Integrin alpha-L/0.471
1ia3TQ5Dihydrofolate reductase1.5.1.30.471
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.471
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.471
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.471
4nb6444Nuclear receptor ROR-gamma/0.471
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.471
3qakUKAAdenosine receptor A2a/0.471
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.470
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.470
1og5SWFCytochrome P450 2C9/0.470
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.470
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.470
4kaoKAOFocal adhesion kinase 12.7.10.20.470
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.470
1jtqLY3Thymidylate synthase/0.469
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.469
3qlzQLZUncharacterized protein/0.469
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.469
4qnaX11Serine/threonine-protein kinase 242.7.11.10.469
1hfpMOTDihydrofolate reductase1.5.1.30.468
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.468
2hk9NAPShikimate dehydrogenase (NADP(+))/0.468
3abaFLICytochrome P450/0.468
3cqeP91Wee1-like protein kinase2.7.10.20.468
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.468
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.468
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.468
4ib4ERM5-hydroxytryptamine receptor 2B/0.468
4iq71G9Mycocyclosin synthase1.14.21.90.468
4j6bPLOCytochrome P450 monooxygenase/0.468
4jx1CAHCamphor 5-monooxygenase1.14.15.10.468
4jx1CAMCamphor 5-monooxygenase1.14.15.10.468
4qo9627Serine/threonine-protein kinase 242.7.11.10.468
1s3yTQTDihydrofolate reductase1.5.1.30.467
1x8lOXRRetinol dehydratase/0.467
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.467
2w3vTOPDihydrofolate reductase/0.467
2z7gEH9Adenosine deaminase3.5.4.40.467
3p6nDSOCamphor 5-monooxygenase1.14.15.10.467
3tdaPN0Cytochrome P450 2D6/0.467
4htx19FcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.467
4i8vBHFCytochrome P450 1A11.14.14.10.467
4ia7BIVVitamin D3 receptor A/0.467
4qmzB49Serine/threonine-protein kinase 242.7.11.10.467
5d1bTSNHistone deacetylase 83.5.1.980.467
1bq1CB3Thymidylate synthase/0.466
1s0xC3SNuclear receptor ROR-alpha/0.466
1upw444Oxysterols receptor LXR-beta/0.466
2nnqT4BFatty acid-binding protein, adipocyte/0.466
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.466
3o9lLPNRenin3.4.23.150.466
4g2i0VQVitamin D3 receptor/0.466
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.466
4kak06UDihydrofolate reductase1.5.1.30.466
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.466
4qa0SHHHistone deacetylase 83.5.1.980.466
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
1xu9CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.465
2i0ePDSProtein kinase C beta type2.7.11.130.465
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.465
3e6oA55Nitric oxide synthase, inducible1.14.13.390.465
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.465
3ge7AFQQueuine tRNA-ribosyltransferase2.4.2.290.465
3vwdACOAlpha-tubulin N-acetyltransferase 1/0.465
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.465
3uzcT4EAdenosine receptor A2a/0.465
1v7aFRCAdenosine deaminase3.5.4.40.464
3hu2AGSTransitional endoplasmic reticulum ATPase3.6.4.60.464
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.463
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.463
3is9AC7Gag-Pol polyprotein2.7.7.490.463
4e6a0O9Mitogen-activated protein kinase 14/0.463
4ia1BIVVitamin D3 receptor A/0.463
5aaaVGHALK tyrosine kinase receptor2.7.10.10.463
5k2cZMAAdenosine receptor A2a/0.463
1hb1OCVIsopenicillin N synthase1.21.3.10.462
1kt3RTLRetinol-binding protein 4/0.462
1uzwCDHIsopenicillin N synthase1.21.3.10.462
1zprCB3Thymidylate synthase/0.462
3s7a684Dihydrofolate reductase1.5.1.30.462
4iw8KN3Estrogen receptor/0.462
4qa2SHHHistone deacetylase 83.5.1.980.462
1h35R01Squalene--hopene cyclase4.2.1.1290.461
1ly4COQDihydrofolate reductase1.5.1.30.461
1o6qR17Squalene--hopene cyclase4.2.1.1290.461
1rf9DBRCamphor 5-monooxygenase1.14.15.10.461
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.461
3bhlTHGThymidylate synthase/0.461
3iw8HIZMitogen-activated protein kinase 14/0.461
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.461
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
4jq8KJ8Epidermal growth factor receptor2.7.10.10.461
4rbs0RVMetallo-beta-lactamase type 2/0.461
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
1klkPMDDihydrofolate reductase1.5.1.30.460
1m17AQ4Epidermal growth factor receptor2.7.10.10.460
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
2bfyH1NAurora kinase B-A2.7.11.10.460
2iviACWIsopenicillin N synthase1.21.3.10.460
2jb4A14Isopenicillin N synthase1.21.3.10.460
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
2w3wVG9Dihydrofolate reductase/0.460
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.460
3dcv55ESerine/threonine-protein kinase pim-12.7.11.10.460
3k47D09Dihydrofolate reductase1.5.1.30.460
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.460
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.460
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.460
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.460
1s0zEB1Vitamin D3 receptor/0.459
1umlFR4Adenosine deaminase3.5.4.40.459
3b9lAZZSerum albumin/0.459
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.459
3gwfFADCyclohexanone monooxygenase/0.459
3r336MEDihydrofolate reductase1.5.1.30.459
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.459
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.459
5fsxADPUncharacterized protein/0.459
1e7wMTXPteridine reductase 11.5.1.330.458
1ne4RP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.458
1obnASVIsopenicillin N synthase1.21.3.10.458
2ftoCB3Thymidylate synthase/0.458
3biz61EWee1-like protein kinase2.7.10.20.458
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.458
3cv9VDXVitamin D3 dihydroxylase/0.458
3njoPYVAbscisic acid receptor PYR1/0.458
4ansVGHALK tyrosine kinase receptor2.7.10.10.458
4bchT7ZCyclin-dependent kinase 92.7.11.220.458
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
5bp9SAHPutative methyltransferase protein/0.458
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.457
1osvCHCBile acid receptor/0.457
1qxlFR8Adenosine deaminase3.5.4.40.457
1s9qOHTEstrogen-related receptor gamma/0.457
2acwUPGGlycosyltransferase/0.457
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.457
2i0v6C3Macrophage colony-stimulating factor 1 receptor2.7.10.10.457
2lbaCHOFatty acid binding protein 6/0.457
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.457
2xvw9NRSerum albumin/0.457
3a783EVVitamin D3 receptor/0.457
3naxMP73-phosphoinositide-dependent protein kinase 12.7.11.10.457
3p6mDSOCamphor 5-monooxygenase1.14.15.10.457
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4lt63ATPoly(A) polymerase gamma2.7.7.190.457
4o4fATPKinase/0.457
5dc5B3NHistone deacetylase 83.5.1.980.457
1m79MQ1Dihydrofolate reductase1.5.1.30.456
1nq7ARLNuclear receptor ROR-beta/0.456
1oc1ASVIsopenicillin N synthase1.21.3.10.456
2fziDH3Dihydrofolate reductase1.5.1.30.456
2vbpVB1Isopenicillin N synthase1.21.3.10.456
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
3eblGA4Gibberellin receptor GID1/0.456
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.456
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.456
4h9753SDihydrofolate reductase1.5.1.30.456
4ips1G4Mycocyclosin synthase1.14.21.90.456
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.456
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.456
1ie8KH1Vitamin D3 receptor/0.455
1nytNAPShikimate dehydrogenase (NADP(+))/0.455
1r2jFADFkbI/0.455
1s3wTQTDihydrofolate reductase1.5.1.30.455
1v79FR7Adenosine deaminase3.5.4.40.455
2oaxSNLMineralocorticoid receptor/0.455
2po7CHDFerrochelatase, mitochondrial4.99.1.10.455
2vmyFFOSerine hydroxymethyltransferase/0.455
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.455
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.455
3p6pA6BCamphor 5-monooxygenase1.14.15.10.455
3rg9WRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.455
3sai9DRDihydrofolate reductase/0.455
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.455
3vw8DF6Hepatocyte growth factor receptor2.7.10.10.455
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.455
4eiyZMAAdenosine receptor A2a/0.455
4ejh0QACytochrome P450 2A131.14.14.10.455
4m6l21VDihydrofolate reductase1.5.1.30.455
4r20AERCytochrome P450 family 17 polypeptide 2/0.455
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.455
1dr3HBIDihydrofolate reductase1.5.1.30.454
1ia4TQ6Dihydrofolate reductase1.5.1.30.454
1kqwRTLCellular retinol-binding protein type II/0.454
1n4hREANuclear receptor ROR-beta/0.454
1q5dEPBEpothilone C/D epoxidase1.140.454
1rk3VDXVitamin D3 receptor/0.454
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.454
2c7xNRBCytochrome P450 monooxygenase PikC/0.454
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.454
2hasC3OVitamin D3 receptor/0.454
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.454
2j4z626Aurora kinase A2.7.11.10.454
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
3gcq1BUMitogen-activated protein kinase 14/0.454
3hv3R49Mitogen-activated protein kinase 14/0.454
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
3nga3NGCasein kinase II subunit alpha2.7.11.10.454
3p9tTCLRepressor/0.454
3uleC69Actin-related protein 3/0.454
4bj9UHBTankyrase-22.4.2.300.454
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.454
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.454
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.454
4nieNBHNuclear receptor ROR-gamma/0.454
5hbsRTLRetinol-binding protein 1/0.454
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
1jtuLYBThymidylate synthase/0.453
1nceCB3Thymidylate synthase/0.453
1re9DSOCamphor 5-monooxygenase1.14.15.10.453
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.453
1zgaHMKIsoflavone 4'-O-methyltransferase/0.453
2iltNN1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
2pulACPMethylthioribose kinase2.7.1.1000.453
3c34KAIGlutamate receptor ionotropic, kainate 1/0.453
3gc9B45Mitogen-activated protein kinase 112.7.11.240.453
3l8sBFFMitogen-activated protein kinase 14/0.453
3oafOAGDihydrofolate reductase1.5.1.30.453
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
3up0D7SaceDAF-12/0.453
3vtcTK3Vitamin D3 receptor/0.453
4bfrJ82Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform2.7.1.1530.453
4gs4ACOAlpha-tubulin N-acetyltransferase 1/0.453
1kzjCB3Thymidylate synthase/0.452
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
1w06W05Isopenicillin N synthase1.21.3.10.452
2ij7TPFMycocyclosin synthase1.14.21.90.452
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.452
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.452
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.452
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.452
3vo30KFVascular endothelial growth factor receptor 22.7.10.10.452
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.452
4b1fKRHGlutamate racemase/0.452
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.452
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.451
1hk5T44Serum albumin/0.451
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.451
2xf3J01Uncharacterized protein/0.451
2y6fM9FIsopenicillin N synthase1.21.3.10.451
3gi3B10Mitogen-activated protein kinase 14/0.451
3vt5YI2Vitamin D3 receptor/0.451
3vtbTKAVitamin D3 receptor/0.451
4a81DXCMajor pollen allergen Bet v 1-A/0.451
4bfvZVVPantothenate kinase2.7.1.330.451
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.451
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.451
4qa1B3NHistone deacetylase 83.5.1.980.451
3rfmCFFAdenosine receptor A2a/0.451
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.450
1rd4L08Integrin alpha-L/0.450
1s3vTQDDihydrofolate reductase1.5.1.30.450
2gpuOHTEstrogen-related receptor gamma/0.450
2oyuIMSProstaglandin G/H synthase 11.14.99.10.450
2w5bAGSSerine/threonine-protein kinase Nek22.7.11.10.450
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.450
3hqdANPKinesin-like protein KIF11/0.450
3qm4PN0Cytochrome P450 2D6/0.450
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
3zoiM2WIsopenicillin N synthase1.21.3.10.450
4anqVGHALK tyrosine kinase receptor2.7.10.10.450
4da8BG2Purine nucleoside phosphorylase DeoD-type2.4.2.10.450
4g95OAGDihydrofolate reductase1.5.1.30.450
4gevCB3Thymidylate synthase/0.450
4i41MIXSerine/threonine-protein kinase pim-12.7.11.10.450
4ia2BIVVitamin D3 receptor A/0.450
4j26ESTEstrogen receptor beta/0.450
4kf1HT5Aryldialkylphosphatase3.1.8.10.450
4ktl1CQCytochrome P450/0.450
4mv4ACPBiotin carboxylase6.3.4.140.450
1dtpAPUDiphtheria toxin/0.449
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
1opbRETRetinol-binding protein 2/0.449
1ysx4EBSerum albumin/0.449
2harOCCVitamin D3 receptor/0.449
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.449
2wpxACOOrf14/0.449
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.449
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.449
3kpzZNEVitamin D3 receptor/0.449
3q2mCKISpectinomycin phosphotransferase/0.449
3qlxQLRUncharacterized protein/0.449
3uvvREARetinoic acid receptor RXR-alpha/0.449
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.449
4cryACOPanD regulatory factor/0.449
4i9i1DYTankyrase-12.4.2.300.449
4ia3BIVVitamin D3 receptor A/0.449
4iwd1JCHepatocyte growth factor receptor2.7.10.10.449
4v010LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b/0.449
4xrgNADHomospermidine synthase2.5.1.440.449
1fm69CRRetinoic acid receptor RXR-alpha/0.448
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.448
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.448
2acxANPG protein-coupled receptor kinase 62.7.11.160.448
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.448
2bjsACVIsopenicillin N synthase1.21.3.10.448
2bu9HFVIsopenicillin N synthase1.21.3.10.448
2hb8MVDVitamin D3 receptor/0.448
2vzmNRBCytochrome P450 monooxygenase PikC/0.448
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
3mdvCL6Cholesterol 24-hydroxylase/0.448
3sgy06WDihydrofolate reductase1.5.1.30.448
3sh25DRDihydrofolate reductase1.5.1.30.448
3zqtTESAndrogen receptor/0.448
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.448
4e37NDPCatalase1.11.1.60.448
4ewqMWLMitogen-activated protein kinase 14/0.448
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4if5ACOAlpha-tubulin N-acetyltransferase 1/0.448
1dg5TOPDihydrofolate reductase1.5.1.30.447
1mc5AHEAlcohol dehydrogenase class-31.1.1.10.447
1s19MC9Vitamin D3 receptor/0.447
1tysDHFThymidylate synthase/0.447
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.447
1vj3TABDihydrofolate reductase1.5.1.30.447
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
2hamC33Vitamin D3 receptor/0.447
2kceD16Thymidylate synthase/0.447
2pmoHMDProtein kinase 7/0.447
2v58LZJBiotin carboxylase6.3.4.140.447
2vbdV10Isopenicillin N synthase1.21.3.10.447
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.447
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.447
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.447
3h1vTK1Glucokinase2.7.1.20.447
3ihgFADAklavinone 12-hydroxylase RdmE/0.447
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.447
3qj5022Alcohol dehydrogenase class-31.1.1.10.447
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
3vrwYS5Vitamin D3 receptor/0.447
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.447
4jq7KJQEpidermal growth factor receptor2.7.10.10.447
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.446
1dhiMTXDihydrofolate reductase1.5.1.30.446
1hb3SCVIsopenicillin N synthase1.21.3.10.446
1l2jETCEstrogen receptor beta/0.446
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
1qnfHDFDeoxyribodipyrimidine photo-lyase4.1.99.30.446
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.446
1rx8FOLDihydrofolate reductase1.5.1.30.446
1synF89Thymidylate synthase/0.446
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.446
1w22NHBHistone deacetylase 83.5.1.980.446
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.446
2c6dANPAurora kinase A2.7.11.10.446
2etm7PYFocal adhesion kinase 12.7.10.20.446
2fzhDH1Dihydrofolate reductase1.5.1.30.446
2gvcFADThiol-specific monooxygenase1.14.130.446
2j9lATPH(+)/Cl(-) exchange transporter 5/0.446
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.446
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.446
2y60M8FIsopenicillin N synthase1.21.3.10.446
2yloTESAndrogen receptor/0.446
3clbTMQBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
3cseN22Uncharacterized protein/0.446
3eej53RUncharacterized protein/0.446
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.446
3lfeZ84Mitogen-activated protein kinase 14/0.446
3nmpPYVAbscisic acid receptor PYL2/0.446
3nr4PYVAbscisic acid receptor PYL2/0.446
3ntz3TZDihydrofolate reductase1.5.1.30.446
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.446
3tnlNADShikimate dehydrogenase (NADP(+))/0.446
3u8hBHPPhospholipase A2, membrane associated/0.446
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.446
3vt65YIVitamin D3 receptor/0.446
4f630S7Fibroblast growth factor receptor 1/0.446
4kodADPTransitional endoplasmic reticulum ATPase3.6.4.60.446
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.446
4o71CPBBromodomain-containing protein 4/0.446
4othDRNSerine/threonine-protein kinase N1/0.446
4q0a4OAVitamin D3 receptor A/0.446
1hpzAAPGag-Pol polyprotein2.7.7.490.445
1iyzNDPProbable quinone oxidoreductase/0.445
1mvsDTMDihydrofolate reductase1.5.1.30.445
1mvtDTMDihydrofolate reductase1.5.1.30.445
1p93DEXGlucocorticoid receptor/0.445
2bfaCB3Pteridine reductase 11.5.1.330.445
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.445
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.445
2ykbYKBHeat shock protein HSP 90-alpha/0.445
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
3fznD7KBenzoylformate decarboxylase4.1.1.70.445
3h18PMSEsterase/lipase/0.445
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3otwCOAPhosphopantetheine adenylyltransferase/0.445
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.445
3sa27DRDihydrofolate reductase/0.445
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.445
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.445
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.445
4iae1DXAlr2278 protein/0.445
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.445
4txiFAD[F-actin]-methionine sulfoxide oxidase MICAL11.14.130.445
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.445
1draMTXDihydrofolate reductase1.5.1.30.444
1drfFOLDihydrofolate reductase1.5.1.30.444
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
1mznBM6Retinoic acid receptor RXR-alpha/0.444
1pq6965Oxysterols receptor LXR-beta/0.444
1rkgVD1Vitamin D3 receptor/0.444
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.444
2bf7HBIPteridine reductase 11.5.1.330.444
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.444
2ejzSAHDiphthine synthase/0.444
2pupADPMethylthioribose kinase2.7.1.1000.444
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.444
2xiyXIYSerine/threonine-protein kinase pim-12.7.11.10.444
2zl9VDAVitamin D3 receptor/0.444
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
3fhxPXLPyridoxal kinase2.7.1.350.444
3fnu006HAP protein/0.444
3hziATPSerine/threonine-protein kinase toxin HipA/0.444
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4fob0USALK tyrosine kinase receptor2.7.10.10.444
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.444
4qzuRTLRetinol-binding protein 2/0.444
5iubCLRAdenosine receptor A2a/0.444
1aoeGW3Dihydrofolate reductase1.5.1.30.443
1fmlRTLRetinol dehydratase/0.443
1hnvTBOGag-Pol polyprotein2.7.7.490.443
1q4xG24Thyroid hormone receptor beta/0.443
1tv8SAMGTP 3',8-cyclase4.1.99.180.443
1xj7DHTAndrogen receptor/0.443
2imkGTXAGAP009194-PA/0.443
2o7pNAPRiboflavin biosynthesis protein RibD/0.443
2qbmCAMCamphor 5-monooxygenase1.14.15.10.443
2zbaZBATrichothecene 3-O-acetyltransferase/0.443
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3dkoIHZEphrin type-A receptor 72.7.10.10.443
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.443
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.443
3up3XCAaceDAF-12/0.443
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.443
4bwaN0BPyrrolysine--tRNA ligase/0.443
4dymIYZActivin receptor type-12.7.11.300.443
4fhi0S4Vitamin D3 receptor A/0.443
4ixd1HVIntegrin alpha-L/0.443
4jvlESTEstrogen sulfotransferase2.8.2.40.443
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.443
4kxl6C62'-deoxynucleoside 5'-phosphate N-hydrolase 1/0.443
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.443
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4nt3ZAWLactoperoxidase1.11.1.70.443
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.443
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.443
5e8wSTUTGF-beta receptor type-12.7.11.300.443
4zj8SUVOrexin receptor type 1/0.443
3emlZMAAdenosine receptor A2a/0.443
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
1kt6RTLRetinol-binding protein 4/0.442
1rx3MTXDihydrofolate reductase1.5.1.30.442
1y5xE89Queuine tRNA-ribosyltransferase2.4.2.290.442
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.442
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.442
2e9dB76Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.442
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.442
2oyeIM8Prostaglandin G/H synthase 11.14.99.10.442
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.442
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2vv9IM9Cyclin-dependent kinase 22.7.11.220.442
2wugHPK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.442
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.442
3bqdDAYGlucocorticoid receptor/0.442
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.442
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.442
3g0fB49Mast/stem cell growth factor receptor Kit2.7.10.10.442
3p99LNPLanosterol 14-alpha-demethylase/0.442
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.442
3srqQ19Dihydrofolate reductase1.5.1.30.442
3srrQ20Dihydrofolate reductase1.5.1.30.442
3w0c6DSVitamin D3 receptor/0.442
4cd2FOLDihydrofolate reductase1.5.1.30.442
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.442
4g1z0VPVitamin D3 receptor A/0.442
4g2fC07Ephrin type-A receptor 32.7.10.10.442
4hvs647Mast/stem cell growth factor receptor Kit2.7.10.10.442
4hw219HInduced myeloid leukemia cell differentiation protein Mcl-1/0.442
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.442
4nc3ERM5-hydroxytryptamine receptor 2B/0.442
1fwmCB3Thymidylate synthase/0.441
1ie9VDXVitamin D3 receptor/0.441
1lhvNOGSex hormone-binding globulin/0.441
1txiTX5Vitamin D3 receptor/0.441
1x8b824Wee1-like protein kinase2.7.10.20.441
2gpvOHTEstrogen-related receptor gamma/0.441
2owb626Serine/threonine-protein kinase PLK12.7.11.210.441
2pauD5M5'-deoxynucleotidase YfbR/0.441
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.441
2wd8VGFPteridine reductase/0.441
3bfb9ODPheromone-binding protein ASP1/0.441
3ezpB3NHistone deacetylase 83.5.1.980.441
3gieACPSensor histidine kinase DesK2.7.13.30.441
3imxB84Glucokinase2.7.1.20.441
3irxUDRGag-Pol polyprotein2.7.7.490.441
3jw5TOPDihydrofolate reductase/0.441
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.441
3ntgD72Prostaglandin G/H synthase 21.14.99.10.441
3p5kP5KMitogen-activated protein kinase 14/0.441
3qlwN22Dihydrofolate reductase1.5.1.30.441
3vkjFNRIsopentenyl-diphosphate delta-isomerase/0.441
4alhA9PBromodomain-containing protein 2/0.441
4eilCB3Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
4ejgNCTCytochrome P450 2A131.14.14.10.441
4jlk1NODeoxycytidine kinase2.7.1.740.441
4jrvKJVEpidermal growth factor receptor2.7.10.10.441
4kd79DRDihydrofolate reductase1.5.1.30.441
4u0mGTPCyclic GMP-AMP synthase/0.441
5g53NECAdenosine receptor A2a/0.441
5k2dZMAAdenosine receptor A2a/0.441
1rx5DDFDihydrofolate reductase1.5.1.30.440
1tduCB3Thymidylate synthase/0.440
1vruAAPGag-Pol polyprotein2.7.7.490.440
2hc4VDXVitamin D3 receptor A/0.440
2rqfJH3Hemolymph juvenile hormone binding protein/0.440
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.440
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.440
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.440
2zlcVDXVitamin D3 receptor/0.440
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.440
3hv6R39Mitogen-activated protein kinase 14/0.440
3i8aN22Dihydrofolate reductase1.5.1.30.440
3oqkS52Renin3.4.23.150.440
3vrvYSDVitamin D3 receptor/0.440
3w5rLOAVitamin D3 receptor/0.440
4ag8AXIVascular endothelial growth factor receptor 22.7.10.10.440
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.440
4fhh0U3Vitamin D3 receptor A/0.440
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.440
4pkl1GHUncharacterized protein/0.440
4qmlANPSerine/threonine-protein kinase 242.7.11.10.440
4zasTYDCalS13/0.440
5dq8FLFTranscriptional enhancer factor TEF-4/0.440
5k2bZMAAdenosine receptor A2a/0.440