Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 1.000 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.568 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.545 | |
| 2wkm | PFY | Hepatocyte growth factor receptor | 2.7.10.1 | 0.540 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.537 | |
| 3zc5 | W9Z | Hepatocyte growth factor receptor | 2.7.10.1 | 0.532 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.528 | |
| 2wgj | VGH | Hepatocyte growth factor receptor | 2.7.10.1 | 0.523 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.523 | |
| 4gg5 | 0J3 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.521 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.520 | |
| 4aoi | 4K0 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.513 | |
| 3iw4 | LW4 | Protein kinase C alpha type | 2.7.11.13 | 0.508 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.507 | |
| 4b8m | VX6 | Aurora kinase B-A | 2.7.11.1 | 0.507 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.507 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.506 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.504 | |
| 4deg | 0JJ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.503 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.501 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.501 | |
| 4af3 | VX6 | Aurora kinase B | 2.7.11.1 | 0.499 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.496 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.494 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.493 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.493 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.492 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.492 | |
| 1r0e | DFN | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.490 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.490 | |
| 3zxz | KRW | Hepatocyte growth factor receptor | 2.7.10.1 | 0.490 | |
| 4ap7 | F47 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.489 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.489 | |
| 2pun | ACP | Methylthioribose kinase | 2.7.1.100 | 0.488 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.488 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.487 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.487 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.487 | |
| 3zbx | 6XE | Hepatocyte growth factor receptor | 2.7.10.1 | 0.487 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.487 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.486 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.486 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.486 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.485 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.485 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.484 | |
| 4c2w | ANP | Aurora kinase B-A | 2.7.11.1 | 0.484 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.484 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.483 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.483 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.483 | |
| 1xws | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.482 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.482 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.481 | |
| 2bil | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.481 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.481 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.481 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.481 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.480 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.479 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.479 | |
| 2ow3 | BIM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.479 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.479 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.478 | |
| 3f82 | 353 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.478 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.478 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.478 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.477 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 3r02 | UNM | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.476 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.476 | |
| 4a99 | MIY | TetX family tetracycline inactivation enzyme | / | 0.476 | |
| 4at5 | MUJ | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.476 | |
| 4kln | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.476 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.475 | |
| 3qly | 55V | Uncharacterized protein | / | 0.475 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.475 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.475 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.474 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.474 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.474 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.474 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.473 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.473 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.473 | |
| 1yi4 | ADN | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.472 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.472 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.472 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.472 | |
| 2xvv | 9DN | Serum albumin | / | 0.472 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.472 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.472 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.471 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.471 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.471 | |
| 4i0t | 1B6 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.471 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.471 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.471 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.471 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.470 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.470 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.470 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.470 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 4kao | KAO | Focal adhesion kinase 1 | 2.7.10.2 | 0.470 | |
| 4lm5 | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.470 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.469 | |
| 3bgz | VX3 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.469 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.469 | |
| 4dtk | 7LI | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.469 | |
| 4qna | X11 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.469 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.468 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.468 | |
| 3aba | FLI | Cytochrome P450 | / | 0.468 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.468 | |
| 3jpv | 1DR | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.468 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.468 | |
| 4a7c | E46 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.468 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.468 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.468 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.468 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.468 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.468 | |
| 4qo9 | 627 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.468 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.467 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.467 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.467 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.467 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.467 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.467 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.467 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.467 | |
| 4qmz | B49 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.467 | |
| 5d1b | TSN | Histone deacetylase 8 | 3.5.1.98 | 0.467 | |
| 1bq1 | CB3 | Thymidylate synthase | / | 0.466 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.466 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.466 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.466 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.466 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.466 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.466 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.466 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.466 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.466 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.465 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.465 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.465 | |
| 3e6o | A55 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.465 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.465 | |
| 3ge7 | AFQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.465 | |
| 3vwd | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.465 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.465 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.465 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.465 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.464 | |
| 3hu2 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.464 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 3cy3 | JN5 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.463 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.463 | |
| 4e6a | 0O9 | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.463 | |
| 5aaa | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.463 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.463 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.462 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 1zpr | CB3 | Thymidylate synthase | / | 0.462 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.462 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.462 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.461 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.461 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 2j2i | LY4 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.461 | |
| 3bhl | THG | Thymidylate synthase | / | 0.461 | |
| 3iw8 | HIZ | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.461 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.461 | |
| 4rbs | 0RV | Metallo-beta-lactamase type 2 | / | 0.461 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.460 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 2bfy | H1N | Aurora kinase B-A | 2.7.11.1 | 0.460 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.460 | |
| 3bgp | VX1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.460 | |
| 3dcv | 55E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.460 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.460 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.460 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.460 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.459 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.459 | |
| 3b9l | AZZ | Serum albumin | / | 0.459 | |
| 3c4e | C4E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.459 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.459 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.459 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.459 | |
| 5fsx | ADP | Uncharacterized protein | / | 0.459 | |
| 1e7w | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.458 | |
| 1ne4 | RP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.458 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.458 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.458 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.458 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.458 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.458 | |
| 4ans | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.458 | |
| 4bch | T7Z | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.458 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.458 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.457 | |
| 1osv | CHC | Bile acid receptor | / | 0.457 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.457 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.457 | |
| 2acw | UPG | Glycosyltransferase | / | 0.457 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.457 | |
| 2i0v | 6C3 | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.457 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.457 | |
| 2wqo | VGK | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.457 | |
| 2xvw | 9NR | Serum albumin | / | 0.457 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.457 | |
| 3nax | MP7 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.457 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 4lt6 | 3AT | Poly(A) polymerase gamma | 2.7.7.19 | 0.457 | |
| 4o4f | ATP | Kinase | / | 0.457 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.457 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.456 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.456 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.456 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.456 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.456 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.456 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.456 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.455 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.455 | |
| 1r2j | FAD | FkbI | / | 0.455 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1v79 | FR7 | Adenosine deaminase | 3.5.4.4 | 0.455 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.455 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 2vmy | FFO | Serine hydroxymethyltransferase | / | 0.455 | |
| 3ncg | BK1 | Calmodulin-domain protein kinase 1, putative | / | 0.455 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.455 | |
| 3uix | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 3vw8 | DF6 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.455 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.455 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.455 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.455 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.455 | |
| 5dgz | L20 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.454 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.454 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.454 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.454 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 1yhs | STU | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.454 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.454 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.454 | |
| 2j4z | 626 | Aurora kinase A | 2.7.11.1 | 0.454 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.454 | |
| 3p9t | TCL | Repressor | / | 0.454 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.454 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.454 | |
| 4h1j | 0YH | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.454 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.454 | |
| 4k18 | 1OB | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.454 | |
| 5hbs | RTL | Retinol-binding protein 1 | / | 0.454 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.453 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.453 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 1yi3 | LY2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.453 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.453 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 0.453 | |
| 3c34 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.453 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.453 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 3up0 | D7S | aceDAF-12 | / | 0.453 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.453 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.453 | |
| 4gs4 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.453 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.452 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.452 | |
| 2xke | WI2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.452 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.452 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.452 | |
| 3vbq | 0F5 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 3vo3 | 0KF | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.452 | |
| 3vso | EK1 | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 4b1f | KRH | Glutamate racemase | / | 0.452 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.451 | |
| 1hk5 | T44 | Serum albumin | / | 0.451 | |
| 2qhn | 582 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.451 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 3gi3 | B10 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.451 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.451 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.451 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4c8b | 0LI | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.451 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.451 | |
| 4qa1 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.451 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.451 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.450 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2gpu | OHT | Estrogen-related receptor gamma | / | 0.450 | |
| 2oyu | IMS | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.450 | |
| 2w5b | AGS | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.450 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 3hqd | ANP | Kinesin-like protein KIF11 | / | 0.450 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.450 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4anq | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.450 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.450 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.450 | |
| 4i41 | MIX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 4j26 | EST | Estrogen receptor beta | / | 0.450 | |
| 4kf1 | HT5 | Aryldialkylphosphatase | 3.1.8.1 | 0.450 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.450 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.450 | |
| 1dtp | APU | Diphtheria toxin | / | 0.449 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.449 | |
| 1ysx | 4EB | Serum albumin | / | 0.449 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.449 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 2wpx | ACO | Orf14 | / | 0.449 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.449 | |
| 3q2m | CKI | Spectinomycin phosphotransferase | / | 0.449 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.449 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.449 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.449 | |
| 4cry | ACO | PanD regulatory factor | / | 0.449 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.449 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.449 | |
| 4iwd | 1JC | Hepatocyte growth factor receptor | 2.7.10.1 | 0.449 | |
| 4v01 | 0LI | Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b | / | 0.449 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.449 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.448 | |
| 2acx | ANP | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.448 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.448 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.448 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.448 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.448 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3zqt | TES | Androgen receptor | / | 0.448 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.448 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.448 | |
| 4ewq | MWL | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4if5 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.448 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.447 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.447 | |
| 1tys | DHF | Thymidylate synthase | / | 0.447 | |
| 1uu7 | BI2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.447 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.447 | |
| 2kce | D16 | Thymidylate synthase | / | 0.447 | |
| 2pmo | HMD | Protein kinase 7 | / | 0.447 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.447 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.447 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.447 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.447 | |
| 3ihg | FAD | Aklavinone 12-hydroxylase RdmE | / | 0.447 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.447 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.447 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.447 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.446 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1qnf | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.446 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1syn | F89 | Thymidylate synthase | / | 0.446 | |
| 1uu3 | LY4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.446 | |
| 1w22 | NHB | Histone deacetylase 8 | 3.5.1.98 | 0.446 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2c6d | ANP | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 2etm | 7PY | Focal adhesion kinase 1 | 2.7.10.2 | 0.446 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.446 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.446 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.446 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.446 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2ylo | TES | Androgen receptor | / | 0.446 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3cse | N22 | Uncharacterized protein | / | 0.446 | |
| 3eej | 53R | Uncharacterized protein | / | 0.446 | |
| 3jxw | LXG | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.446 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.446 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.446 | |
| 4f63 | 0S7 | Fibroblast growth factor receptor 1 | / | 0.446 | |
| 4kod | ADP | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.446 | |
| 4lmu | QUE | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.446 | |
| 4oth | DRN | Serine/threonine-protein kinase N1 | / | 0.446 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.446 | |
| 1hpz | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.445 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1p93 | DEX | Glucocorticoid receptor | / | 0.445 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.445 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.445 | |
| 2xk4 | OL2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.445 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.445 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.445 | |
| 3h18 | PMS | Esterase/lipase | / | 0.445 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.445 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.445 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.445 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.445 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 4iae | 1DX | Alr2278 protein | / | 0.445 | |
| 4n6z | 2HW | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 4txi | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.445 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.444 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.444 | |
| 1uu8 | BI1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.444 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 2ejz | SAH | Diphthine synthase | / | 0.444 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.444 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 2xiy | XIY | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.444 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 3fnu | 006 | HAP protein | / | 0.444 | |
| 3hzi | ATP | Serine/threonine-protein kinase toxin HipA | / | 0.444 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 4fob | 0US | ALK tyrosine kinase receptor | 2.7.10.1 | 0.444 | |
| 4qmt | H1N | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.444 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.444 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.444 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1fml | RTL | Retinol dehydratase | / | 0.443 | |
| 1hnv | TBO | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1q4x | G24 | Thyroid hormone receptor beta | / | 0.443 | |
| 1tv8 | SAM | GTP 3',8-cyclase | 4.1.99.18 | 0.443 | |
| 1xj7 | DHT | Androgen receptor | / | 0.443 | |
| 2imk | GTX | AGAP009194-PA | / | 0.443 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.443 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.443 | |
| 3ag9 | A02 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3dko | IHZ | Ephrin type-A receptor 7 | 2.7.10.1 | 0.443 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.443 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 3up3 | XCA | aceDAF-12 | / | 0.443 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.443 | |
| 4bwa | N0B | Pyrrolysine--tRNA ligase | / | 0.443 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.443 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.443 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.443 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.443 | |
| 4k1b | 1OC | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 4kxl | 6C6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.443 | |
| 4mbl | 26L | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4nt3 | ZAW | Lactoperoxidase | 1.11.1.7 | 0.443 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.443 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.443 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.443 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.443 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.442 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1y5x | E89 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.442 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.442 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.442 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 2oye | IM8 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.442 | |
| 2pe2 | 464 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2vv9 | IM9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2wug | HPK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.442 | |
| 2xch | CKG | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 3bqd | DAY | Glucocorticoid receptor | / | 0.442 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.442 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.442 | |
| 3g0f | B49 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.442 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.442 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.442 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4f1m | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.442 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.442 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.442 | |
| 4hvs | 647 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.442 | |
| 4hw2 | 19H | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.442 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.442 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.442 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.441 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.441 | |
| 1lhv | NOG | Sex hormone-binding globulin | / | 0.441 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.441 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.441 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.441 | |
| 2owb | 626 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.441 | |
| 2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.441 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.441 | |
| 2wd8 | VGF | Pteridine reductase | / | 0.441 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.441 | |
| 3ezp | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.441 | |
| 3imx | B84 | Glucokinase | 2.7.1.2 | 0.441 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.441 | |
| 3ma3 | 01I | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 3ntg | D72 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.441 | |
| 3p5k | P5K | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3vkj | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.441 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.441 | |
| 4eil | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.441 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.441 | |
| 4jrv | KJV | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.441 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.441 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.440 | |
| 1vru | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.440 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.440 | |
| 2xj1 | XJ1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.440 | |
| 2xkf | BX1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.440 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.440 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.440 | |
| 3hv6 | R39 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.440 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.440 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.440 | |
| 4ag8 | AXI | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.440 | |
| 4bl1 | ANP | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.440 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.440 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.440 | |
| 4pkl | 1GH | Uncharacterized protein | / | 0.440 | |
| 4qml | ANP | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.440 | |
| 4zas | TYD | CalS13 | / | 0.440 | |
| 5dq8 | FLF | Transcriptional enhancer factor TEF-4 | / | 0.440 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.440 |