sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3c14 | FOK | Adenylate cyclase type 2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3c14 | FOK | Adenylate cyclase type 2 | / | 1.000 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 1.000 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.662 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.662 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.660 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.660 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.657 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.657 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.642 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.642 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.639 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.639 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.624 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.624 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.622 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.622 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.606 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.606 | |
| 1cjv | FOK | Adenylate cyclase type 2 | / | 0.600 | |
| 1cjv | FOK | Adenylate cyclase type 5 | / | 0.600 | |
| 3c16 | FOK | Adenylate cyclase type 2 | / | 0.594 | |
| 3c16 | FOK | Adenylate cyclase type 5 | / | 0.594 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.586 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.586 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.575 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.575 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.491 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.474 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.473 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.467 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.465 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.464 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.463 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.463 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.461 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.461 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.460 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.460 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.459 | |
| 1eio | GCH | Gastrotropin | / | 0.458 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.458 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.457 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.457 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.457 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.457 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.456 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.454 | |
| 3b9l | AZZ | Serum albumin | / | 0.454 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.453 | |
| 3g8e | IS1 | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.453 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.453 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.452 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.451 | |
| 3ey9 | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.451 | |
| 4l4x | NDP | AmphI | / | 0.451 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.450 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.450 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.449 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.449 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.449 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.449 | |
| 3ogw | IMN | Lactoperoxidase | 1.11.1.7 | 0.449 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.449 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.449 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.448 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.448 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1r2j | FAD | FkbI | / | 0.447 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.447 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.447 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4jbs | P52 | Endoplasmic reticulum aminopeptidase 2 | 3.4.11 | 0.447 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1osv | CHC | Bile acid receptor | / | 0.446 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.445 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.445 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.445 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.444 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.444 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.444 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.444 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 4lva | 20M | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.443 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2f6r | ACO | Bifunctional coenzyme A synthase | / | 0.442 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.442 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.441 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.441 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.441 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.441 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.440 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.440 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.440 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.440 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.440 |