Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3bv2P38Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3bv2P38Mitogen-activated protein kinase 14/1.000
3bv3P39Mitogen-activated protein kinase 14/0.497
3e92G6AMitogen-activated protein kinase 14/0.492
1xddAAYIntegrin alpha-L/0.488
3gc9B45Mitogen-activated protein kinase 112.7.11.240.480
2j5xGSPADP-ribosylation factor 6/0.479
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.477
3bx5304Mitogen-activated protein kinase 14/0.477
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.477
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.475
3ds6A17Mitogen-activated protein kinase 14/0.473
4eh60ONMitogen-activated protein kinase 14/0.473
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.471
2gfsPQBMitogen-activated protein kinase 14/0.470
1osvCHCBile acid receptor/0.469
2gtnLIEMitogen-activated protein kinase 14/0.469
3nx4NAPPutative oxidoreductase/0.468
2gjlFMNNitronate monooxygenase1.13.12.160.467
3docNADGlyceraldehyde-3-phosphate dehydrogenase/0.466
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.466
3lzs017Gag-Pol polyprotein3.4.23.160.465
3mpt1GKMitogen-activated protein kinase 14/0.465
1mj9COAHistone acetyltransferase ESA1/0.464
1ot7CHCBile acid receptor/0.464
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.464
3lfa1N1Mitogen-activated protein kinase 14/0.464
3r9uFADThioredoxin reductase/0.464
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.463
3iphG11Mitogen-activated protein kinase 14/0.462
4eh3NARMitogen-activated protein kinase 14/0.462
1tehNADAlcohol dehydrogenase class-31.1.1.10.461
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
1t7kBH0Gag-Pol polyprotein3.4.23.160.459
2ien017Gag-Pol polyprotein3.4.23.160.459
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.459
1mjaCOAHistone acetyltransferase ESA1/0.458
2balPQAMitogen-activated protein kinase 14/0.458
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
4dbzNDPPutative ketoacyl reductase1.3.10.458
2cig1DGDihydrofolate reductase1.5.1.30.457
2i4uDJRProtease/0.457
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.457
3itzP66Mitogen-activated protein kinase 14/0.457
3l8xN4DMitogen-activated protein kinase 14/0.457
1gcoNADGlucose 1-dehydrogenase1.1.1.470.456
1sivPSIGag-Pol polyprotein/0.456
2ozuACOHistone acetyltransferase KAT6A/0.456
3d4pNADL-lactate dehydrogenase 11.1.1.270.456
3flwFLWMitogen-activated protein kinase 14/0.456
3wv9FEGHmd co-occurring protein HcgE/0.456
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
2zb3NDPProstaglandin reductase 21.3.1.480.455
3tog079Gag-Pol polyprotein2.7.7.490.455
1bv9XV6Gag-Pol polyprotein3.4.23.160.454
2d29FADAcyl-CoA dehydrogenase/0.454
3i7eDJRGag-Pol polyprotein/0.454
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.454
1w7h3IPMitogen-activated protein kinase 14/0.453
3jynNDPQuinone oxidoreductase/0.453
3vtdTKDVitamin D3 receptor/0.453
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.452
1fy7COAHistone acetyltransferase ESA1/0.452
2ou2ACOHistone acetyltransferase KAT5/0.452
2rg6287Mitogen-activated protein kinase 14/0.452
2fy4COACholine O-acetyltransferase2.3.1.60.451
2r43G3GGag-Pol polyprotein3.4.23.160.451
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.451
3zbsOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.451
4a4qUX9Pol protein/0.451
4tuvCPZCytochrome P450 1191.140.451
1hbvGANGag-Pol polyprotein/0.450
2avvMK1Gag-Pol polyprotein3.4.23.160.450
2gnaGDUUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.450
2pwrG4GGag-Pol polyprotein3.4.23.160.450
2uxoTACHTH-type transcriptional regulator TtgR/0.450
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.450
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.450
3nbvANPKetohexokinase/0.450
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.450
3uteFADUDP-galactopyranose mutase/0.450
3zsi52PMitogen-activated protein kinase 14/0.450
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.450
4i4b1CV3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.450
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.450
4kb9G79Protease/0.450
5a3cNADSIR2 family protein/0.450
5hwsNAP2-dehydropantoate 2-reductase/0.450
1hsgMK1Gag-Pol polyprotein/0.449
1nytNAPShikimate dehydrogenase (NADP(+))/0.449
1yb5NAPQuinone oxidoreductase1.6.5.50.449
2ad5ADPCTP synthase/0.449
2y05NAPProstaglandin reductase 1/0.449
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.449
3h59H59Genome polyprotein2.7.7.480.449
3oxv478Gag-Pol polyprotein3.4.23.160.449
4m4922YL-lactate dehydrogenase A chain1.1.1.270.449
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.449
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.448
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.448
3aidARQGag-Pol polyprotein3.4.23.160.448
3b70NAPEnoyl reductase LovC10.448
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.448
4u03GTPCyclic GMP-AMP synthase/0.448
1dr3TAPDihydrofolate reductase1.5.1.30.447
2zb0GK3Mitogen-activated protein kinase 14/0.447
3slkNDPPolyketide synthase extender module 2/0.447
4uymVOR14-alpha sterol demethylase Cyp51B/0.447
5dp2NAPCurF/0.447
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.447
2gtmLIDMitogen-activated protein kinase 14/0.446
2qbuSAHPrecorrin-2 methyltransferase/0.446
2rg5279Mitogen-activated protein kinase 14/0.446
2rkfAB1Pol protein/0.446
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.446
3lqfNADGalactitol dehydrogenase/0.446
3uvqFS8Mitogen-activated protein kinase 14/0.446
4tvbNADHomospermidine synthase2.5.1.440.446
1nlmUD1UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase/0.445
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.445
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.445
3btsNADGalactose/lactose metabolism regulatory protein GAL80/0.445
3ec0GRLGag-Pol polyprotein3.4.23.470.445
3fl4FL4Mitogen-activated protein kinase 14/0.445
3mvm39PMitogen-activated protein kinase 14/0.445
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.445
4ia3BIVVitamin D3 receptor A/0.445
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.445
4y9lFADAcyl-CoA dehydrogenase family member 11/0.445
1ipeNDPTropinone reductase 21.1.1.2360.444
2aa3AP0L-lactate dehydrogenase/0.444
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.444
2onmADPAldehyde dehydrogenase, mitochondrial1.2.1.30.444
2pwcG3GGag-Pol polyprotein3.4.23.160.444
3mxdK53Gag-Pol polyprotein3.4.23.160.444
3o9hK2EGag-Pol polyprotein/0.444
3zsh469Mitogen-activated protein kinase 14/0.444
4ejmNAPPutative zinc-binding dehydrogenase/0.444
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.444
1r2jFADFkbI/0.443
1sguMK1Gag-Pol polyprotein3.4.23.160.443
1ykfNAPNADP-dependent isopropanol dehydrogenase1.1.1.800.443
2c29NAPDihydroflavonol 4-reductase/0.443
2i0aMUIProtease/0.443
2psuMUUProtease/0.443
2qnnQN1Gag-Pol polyprotein3.4.23.160.443
3hub469Mitogen-activated protein kinase 14/0.443
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.443
3uylTYDProbable NDP-rhamnosyltransferase/0.443
4enhFVXCholesterol 24-hydroxylase/0.443
4jx1CAHCamphor 5-monooxygenase1.14.15.10.443
4xguADPPutative pachytene checkpoint protein 2/0.443
1xl5190Gag-Pol polyprotein3.4.23.160.442
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.442
4bfxZVXPantothenate kinase2.7.1.330.442
4q73FADBifunctional protein PutA/0.442
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.441
1u3cFADCryptochrome-1/0.441
1z1rHBHGag-Pol polyprotein3.4.23.160.441
2qo9ANPEphrin type-A receptor 32.7.10.10.441
2vn0TDZCytochrome P450 2C8/0.441
2x7hPFNProstaglandin reductase 310.441
3dm5GDPSignal recognition particle 54 kDa protein/0.441
3to6LYS_CMCHistone acetyltransferase ESA1/0.441
4bb3KKAIsopenicillin N synthase1.21.3.10.441
4c3sNADAldehyde Dehydrogenase/0.441
4du82P0Mevalonate diphosphate decarboxylase/0.441
4g7gVFVLanosterol 14-alpha-demethylase/0.441
4i8zG08Gag-Pol polyprotein3.4.23.160.441
4qecNAPElxO/0.441
5dozNDPJamJ/0.441
1geeNADGlucose 1-dehydrogenase1.1.1.470.440
1kkq471Peroxisome proliferator-activated receptor alpha/0.440
1lbcCYZGlutamate receptor 2/0.440
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.440
2ft9CHDFatty acid-binding protein 2, liver/0.440
2q3kMUWGag-Pol polyprotein/0.440
2vnaNAPProstaglandin reductase 21.3.1.480.440
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.440
2y0mACOHistone acetyltransferase KAT8/0.440
3d7zGK5Mitogen-activated protein kinase 14/0.440
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.440
3iaaTYDCalG2/0.440
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.440
3m6iNADL-arabinitol 4-dehydrogenase1.1.1.120.440
3r5yF42Uncharacterized protein/0.440
4c0bATPmRNA cleavage and polyadenylation factor CLP1/0.440
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.440
4eudCOASuccinyl-CoA:acetate CoA-transferase/0.440
4oze24GUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.440