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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3biz61EWee1-like protein kinase2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3biz61EWee1-like protein kinase2.7.10.21.000
3cr0809Wee1-like protein kinase2.7.10.20.816
2z2w770Wee1-like protein kinase2.7.10.20.726
2io6330Wee1-like protein kinase2.7.10.20.719
3cqeP91Wee1-like protein kinase2.7.10.20.693
1x8b824Wee1-like protein kinase2.7.10.20.675
3bi6396Wee1-like protein kinase2.7.10.20.660
2in6839Wee1-like protein kinase2.7.10.20.632
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.521
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.520
2yac937Serine/threonine-protein kinase PLK12.7.11.210.519
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.517
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.513
3zh8C58Protein kinase C iota type2.7.11.130.505
4riyADPEpidermal growth factor receptor2.7.10.10.501
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.497
4c02TAKActivin receptor type-12.7.11.300.495
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.493
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.493
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.491
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.491
4iarERM5-hydroxytryptamine receptor 1B/0.491
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.489
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.489
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.488
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.488
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.487
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.487
4qnaX11Serine/threonine-protein kinase 242.7.11.10.485
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.484
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.483
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.483
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.483
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.480
2wipP49Cyclin-dependent kinase 22.7.11.220.480
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.477
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
3zep1NXTyrosine-protein kinase JAK32.7.10.20.476
4jq8KJ8Epidermal growth factor receptor2.7.10.10.476
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.476
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.475
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.475
2vd5BI8Myotonin-protein kinase2.7.11.10.474
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.473
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.473
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.472
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.471
3zewSTUEphrin type-B receptor 42.7.10.10.471
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.471
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.470
4gk3L87Ephrin type-A receptor 32.7.10.10.470
2j9lATPH(+)/Cl(-) exchange transporter 5/0.469
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.469
3hz5Z64Heat shock protein HSP 90-alpha/0.468
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.467
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.466
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.466
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.466
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.465
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.464
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.464
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.464
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.463
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.462
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.462
3arvSAUChitinase A/0.462
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.462
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.461
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.461
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.461
2yn8STUEphrin type-B receptor 42.7.10.10.461
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.461
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.461
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.460
4c62XWWTyrosine-protein kinase JAK2/0.460
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.460
2qo9ANPEphrin type-A receptor 32.7.10.10.459
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.458
1u54ACPActivated CDC42 kinase 1/0.458
2owb626Serine/threonine-protein kinase PLK12.7.11.210.458
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.458
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.458
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.458
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.458
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.458
1mczRMNBenzoylformate decarboxylase4.1.1.70.457
2i9kSAHModification methylase HhaI2.1.1.370.457
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.457
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2hog710Serine/threonine-protein kinase Chk12.7.11.10.456
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.456
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.456
4k39SAMAnaerobic sulfatase-maturating enzyme1.8.980.456
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.455
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.455
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.455
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.454
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.454
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.454
4jr3KJREpidermal growth factor receptor2.7.10.10.454
2rcwAAIPoly [ADP-ribose] polymerase 12.4.2.300.453
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.453
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.453
4gmy0X5Tyrosine-protein kinase JAK2/0.453
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.452
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.452
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.452
4eb5PLPCysteine desulfurase IscS 2/0.452
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.452
4wkqIREEpidermal growth factor receptor2.7.10.10.452
3qakUKAAdenosine receptor A2a/0.452
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.451
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.451
2itnANPEpidermal growth factor receptor2.7.10.10.451
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.451
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.451
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.451
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.451
1bygSTUTyrosine-protein kinase CSK/0.450
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.450
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.450
2po7CHDFerrochelatase, mitochondrial4.99.1.10.450
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.450
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.450
2cleF6FTryptophan synthase alpha chain/0.449
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.449
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.449
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.449
5e8wSTUTGF-beta receptor type-12.7.11.300.449
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.448
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.448
2c475IDCasein kinase I isoform gamma-2/0.448
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.448
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.447
2dw4FADLysine-specific histone demethylase 1A10.447
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.447
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.447
4klnAGSTransitional endoplasmic reticulum ATPase3.6.4.60.447
4s1iPLPPyridoxal kinase, putative/0.447
5dozNDPJamJ/0.447
1pq944BOxysterols receptor LXR-beta/0.446
1vjy460TGF-beta receptor type-12.7.11.300.446
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.446
2i0v6C3Macrophage colony-stimulating factor 1 receptor2.7.10.10.446
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.446
3pqbVGPPutative oxidoreductase/0.446
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.446
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.446
4k9yK9YFocal adhesion kinase 12.7.10.20.446
2hk51BMTyrosine-protein kinase HCK2.7.10.20.445
3ac1KZITyrosine-protein kinase Lck2.7.10.20.445
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.445
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.445
4jq7KJQEpidermal growth factor receptor2.7.10.10.445
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.444
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.444
1x1cSAHC-20 methyltransferase/0.444
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.444
2vrjNCWBeta-glucosidase A3.2.1.210.444
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.444
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.444
3zsh469Mitogen-activated protein kinase 14/0.444
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.444
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.443
1xddAAYIntegrin alpha-L/0.443
3fznD7KBenzoylformate decarboxylase4.1.1.70.443
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
4k37SAMAnaerobic sulfatase-maturating enzyme1.8.980.443
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.442
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.442
3ig6438Urokinase-type plasminogen activator3.4.21.730.442
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.442
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.442
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.442
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
5dp2NAPCurF/0.442
1py5PY1TGF-beta receptor type-12.7.11.300.441
1rw8580TGF-beta receptor type-12.7.11.300.441
1z6tADPApoptotic protease-activating factor 1/0.441
2ittAEEEpidermal growth factor receptor2.7.10.10.441
2xyuQ9GEphrin type-A receptor 42.7.10.10.441
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3hu2AGSTransitional endoplasmic reticulum ATPase3.6.4.60.441
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.441
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
1uyfPU1Heat shock protein HSP 90-alpha/0.440
4bfxZVXPantothenate kinase2.7.1.330.440
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.440