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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3bgxTMPThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3bgxTMPThymidylate synthase/1.000
1tysTMPThymidylate synthase/0.542
1jmgUMPThymidylate synthase/0.537
1bidUMPThymidylate synthase/0.523
2vetUMPThymidylate synthase/0.518
1tsvUMPThymidylate synthase/0.514
2g86UMPThymidylate synthase/0.514
1tsxUMPThymidylate synthase/0.512
1jmfUMPThymidylate synthase/0.507
2g8aUMPThymidylate synthase/0.506
1njbUMPThymidylate synthase/0.504
1jmiUMPThymidylate synthase/0.501
1vzbUMPThymidylate synthase/0.499
1tsyUMPThymidylate synthase/0.497
2tdmUMPThymidylate synthase/0.494
1lcbTMPThymidylate synthase/0.492
1jmhUMPThymidylate synthase/0.491
4iskUMPThymidylate synthase/0.491
1vzaUMPThymidylate synthase/0.485
2g89UMPThymidylate synthase/0.483
1bduDURThymidylate synthase/0.480
1njdUMPThymidylate synthase/0.479
1njeDCMThymidylate synthase/0.479
1aobDDUThymidylate synthase/0.477
1bp6UMPThymidylate synthase/0.459
1bpjUMPThymidylate synthase/0.458
2ftoTMPThymidylate synthase/0.453
1njaDCMThymidylate synthase/0.452
1thyUMPThymidylate synthase/0.444