Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 1.000 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.609 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.569 | |
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.566 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.566 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.564 | |
| 2p2h | 994 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.553 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.552 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.552 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.541 | |
| 4tyj | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.532 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.530 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.527 | |
| 2og8 | 1N8 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.526 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.524 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.522 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.517 | |
| 2i1m | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.516 | |
| 4v01 | 0LI | Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b | / | 0.514 | |
| 2oiq | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.512 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.510 | |
| 2hyy | STI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.509 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.507 | |
| 4qrc | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.507 | |
| 2oh4 | GIG | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.504 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.498 | |
| 4kao | KAO | Focal adhesion kinase 1 | 2.7.10.2 | 0.498 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.496 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.495 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.494 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.492 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.492 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.492 | |
| 3p9t | TCL | Repressor | / | 0.492 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.492 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.492 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.491 | |
| 4h1j | 0YH | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.491 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.490 | |
| 3qri | 919 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.490 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.490 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.489 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.489 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.489 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.488 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.488 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.488 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.487 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.487 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.487 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.487 | |
| 1m52 | P17 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.486 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.486 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.486 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.486 | |
| 4uxq | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.486 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.485 | |
| 3eta | 351 | Insulin receptor | 2.7.10.1 | 0.485 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.484 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.484 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.483 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.481 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.481 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.480 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.480 | |
| 3vo3 | 0KF | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.480 | |
| 5dp2 | NAP | CurF | / | 0.480 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.479 | |
| 3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.479 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.479 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.478 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.478 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.478 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.478 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.478 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.478 | |
| 2f4j | VX6 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.476 | |
| 3dko | IHZ | Ephrin type-A receptor 7 | 2.7.10.1 | 0.476 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.475 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
| 2ivu | ZD6 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.475 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.475 | |
| 1mew | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.474 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.474 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.473 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.473 | |
| 3fzt | 4JZ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.473 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.473 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.473 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.472 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.472 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.471 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.471 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.471 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.470 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.470 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.470 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.469 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.469 | |
| 4c8b | 0LI | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.469 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.468 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.468 | |
| 1qcf | PP1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.467 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.467 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.467 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.467 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.467 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.466 | |
| 2yn8 | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.466 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.466 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.466 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.465 | |
| 2ofv | 242 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.465 | |
| 2xk4 | OL2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.465 | |
| 3aba | FLI | Cytochrome P450 | / | 0.465 | |
| 3ac2 | KSE | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.465 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.465 | |
| 1qpd | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.464 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.464 | |
| 3c7q | XIN | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.464 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.464 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.464 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.464 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.464 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.464 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.463 | |
| 2zm1 | KSF | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.463 | |
| 3fzs | B96 | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.463 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 5ckw | ANP | Uncharacterized protein | / | 0.463 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.462 | |
| 1fgi | SU1 | Fibroblast growth factor receptor 1 | / | 0.462 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.462 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.462 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.462 | |
| 2i0v | 6C3 | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.461 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.461 | |
| 3ad6 | KSC | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.461 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.461 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 4fic | 0UL | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.461 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.460 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.459 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.459 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2j7t | 274 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.459 | |
| 3ac5 | KZM | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.459 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.459 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.459 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.459 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.459 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.458 | |
| 2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.458 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.458 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.458 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.458 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.458 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.458 | |
| 4mxo | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.458 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.458 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.458 | |
| 2a19 | ANP | Interferon-induced, double-stranded RNA-activated protein kinase | 2.7.11.1 | 0.457 | |
| 2ayp | 43A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 2bdj | HET | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.457 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.457 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3vrz | VRZ | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.457 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.457 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.456 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.456 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.456 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.455 | |
| 2xvd | AS6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.455 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.455 | |
| 3ce3 | 1FN | Hepatocyte growth factor receptor | 2.7.10.1 | 0.455 | |
| 3fko | FKO | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.455 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.455 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.455 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.454 | |
| 1uv5 | BRW | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.453 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.453 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.453 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.453 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3zze | 6XP | Hepatocyte growth factor receptor | 2.7.10.1 | 0.453 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.453 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.453 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.453 | |
| 5doz | NDP | JamJ | / | 0.453 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.452 | |
| 1zdw | FLV | Prenyltransferase | / | 0.452 | |
| 2of2 | 547 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.452 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.452 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 3eel | 53T | Uncharacterized protein | / | 0.451 | |
| 4c62 | XWW | Tyrosine-protein kinase JAK2 | / | 0.451 | |
| 4hvi | 19S | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.451 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.450 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.450 | |
| 2xk7 | 30E | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.450 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3b2w | 9NH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.450 | |
| 3fkl | FKL | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.450 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 4acc | 7YG | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.450 | |
| 4f64 | 0S8 | Fibroblast growth factor receptor 1 | / | 0.450 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4h4o | 506 | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.450 | |
| 1typ | NAP | Trypanothione reductase | 1.8.1.12 | 0.449 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.449 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.449 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.449 | |
| 4feq | 0T8 | Tyrosine-protein kinase receptor TYRO3 | 2.7.10.1 | 0.449 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.449 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.449 | |
| 4zzj | CNA | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.449 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.448 | |
| 2osc | MUH | Angiopoietin-1 receptor | 2.7.10.1 | 0.448 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.448 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4ft0 | HK9 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 4if5 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.448 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.448 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.448 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.447 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.447 | |
| 2owb | 626 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.447 | |
| 2uxx | FAJ | Lysine-specific histone demethylase 1A | 1 | 0.447 | |
| 2vwz | 7X6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.447 | |
| 2zva | 1N1 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.447 | |
| 3g0e | B49 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.447 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.447 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 5kf8 | ACO | Predicted acetyltransferase | / | 0.447 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.446 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.446 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.446 | |
| 3qlg | 1N1 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.446 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.446 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4hvs | 647 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.446 | |
| 4iae | 1DX | Alr2278 protein | / | 0.446 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.446 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.445 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.445 | |
| 1uu8 | BI1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.445 | |
| 1yol | S03 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.445 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.445 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.445 | |
| 3ac3 | KSH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.445 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.445 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3tuc | FPW | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.445 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 4ajg | F07 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.445 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.445 | |
| 4rbs | 0RV | Metallo-beta-lactamase type 2 | / | 0.445 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.445 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.445 | |
| 1e79 | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.444 | |
| 1e79 | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.444 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.444 | |
| 1y6b | AAX | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.444 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 2vwu | 7X1 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.444 | |
| 3ac1 | KZI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.444 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.444 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.444 | |
| 3vs0 | VS0 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.444 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4ach | KDI | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.444 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4fr4 | STU | Serine/threonine-protein kinase 32A | 2.7.11.1 | 0.444 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.444 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.444 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.443 | |
| 1yho | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2xnm | WGZ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.443 | |
| 2xnp | WCX | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.443 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.443 | |
| 3d5w | ADP | Serine/threonine-protein kinase PLK | / | 0.443 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.443 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.443 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.443 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.443 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.442 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.442 | |
| 1xds | DRA | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.442 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.442 | |
| 2qoq | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.442 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.442 | |
| 2zv9 | PP2 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.442 | |
| 3bi5 | FAD | Polyamine oxidase FMS1 | / | 0.442 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.442 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.442 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.442 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.442 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.442 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.442 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.442 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1qpe | PP2 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.441 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.441 | |
| 2e48 | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.441 | |
| 2iw5 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.441 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 3vs3 | VSE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.441 | |
| 4j4v | SVR | Nucleocapsid protein | / | 0.441 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.441 | |
| 4qx5 | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.441 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.440 | |
| 1osv | CHC | Bile acid receptor | / | 0.440 | |
| 1t13 | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | / | 0.440 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2clf | F6F | Tryptophan synthase alpha chain | / | 0.440 | |
| 2ejz | SAH | Diphthine synthase | / | 0.440 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.440 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.440 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.440 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.440 | |
| 3x0a | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.440 | |
| 3zs5 | SB2 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.440 | |
| 4bub | ADP | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase | / | 0.440 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.440 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.440 | |
| 4qi9 | MTX | Dihydrofolate reductase | / | 0.440 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.440 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.440 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.440 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.440 |