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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.11.000
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.637
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.624
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.595
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.594
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.591
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.571
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.563
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.562
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.552
3vs3VSETyrosine-protein kinase HCK2.7.10.20.544
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.542
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.533
3w33W19Epidermal growth factor receptor2.7.10.10.531
1xkkFMMEpidermal growth factor receptor2.7.10.10.530
3vryB43Tyrosine-protein kinase HCK2.7.10.20.530
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.528
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.522
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.521
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.521
3w2sW2REpidermal growth factor receptor2.7.10.10.521
3vs1VSATyrosine-protein kinase HCK2.7.10.20.519
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.519
4hjoAQ4Epidermal growth factor receptor2.7.10.10.515
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.510
4i22IREEpidermal growth factor receptor2.7.10.10.505
3w2rW2REpidermal growth factor receptor2.7.10.10.503
3poz03PEpidermal growth factor receptor2.7.10.10.498
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.497
3w32W32Epidermal growth factor receptor2.7.10.10.497
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.493
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.488
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.486
4id71G0Activated CDC42 kinase 1/0.485
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.483
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.478
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.477
4ih8B43Calmodulin-domain protein kinase 1/0.477
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.475
4aotGW8Serine/threonine-protein kinase 102.7.11.10.471
3l8xN4DMitogen-activated protein kinase 14/0.469
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.467
2hk51BMTyrosine-protein kinase HCK2.7.10.20.467
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.467
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.467
3icrCOACoenzyme A disulfide reductase/0.466
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.465
1m17AQ4Epidermal growth factor receptor2.7.10.10.464
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.464
2ozuACOHistone acetyltransferase KAT6A/0.464
1osvCHCBile acid receptor/0.463
2y6o1N1Ephrin type-A receptor 42.7.10.10.462
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.462
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.461
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.460
2gs7ANPEpidermal growth factor receptor2.7.10.10.460
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.460
4g2fC07Ephrin type-A receptor 32.7.10.10.460
4g7gVFVLanosterol 14-alpha-demethylase/0.460
4jq8KJ8Epidermal growth factor receptor2.7.10.10.459
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.459
3ds6A17Mitogen-activated protein kinase 14/0.457
3h0aD30Peroxisome proliferator-activated receptor gamma/0.457
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.457
1u4dDBQActivated CDC42 kinase 1/0.456
2ebaFADPutative glutaryl-CoA dehydrogenase/0.456
3b6zCO7Enoyl reductase LovC10.456
3b70NAPEnoyl reductase LovC10.456
3mg3ECHOrange carotenoid-binding protein/0.456
4gk2L66Ephrin type-A receptor 32.7.10.10.456
4ocvANPAminoglycoside phosphotransferase/0.456
2c0cNAPProstaglandin reductase 310.455
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.455
3lqfNADGalactitol dehydrogenase/0.455
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.455
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
1k6cMK1Gag-Pol polyprotein3.4.23.160.454
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.454
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.454
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.454
1zemNADXylitol dehydrogenase/0.453
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.453
3uvqFS8Mitogen-activated protein kinase 14/0.453
3ogqAB1Pol polyprotein/0.452
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.452
4kip1R9Mitogen-activated protein kinase 14/0.452
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
3gqvNAPEnoyl reductase LovC10.451
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.451
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.451
4yryFADGlutamate synthase, beta subunit/0.451
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.450
3sgtP09Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)/0.450
3tvuB37Acetyl-CoA carboxylase/0.450
3w18N13Aurora kinase A2.7.11.10.450
4jr3KJREpidermal growth factor receptor2.7.10.10.450
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.450
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.449
2c6eHPMAurora kinase A2.7.11.10.449
3gw9VNILanosterol 14-alpha-demethylase/0.449
4aa5NQBMitogen-activated protein kinase 14/0.449
4aacAAVMitogen-activated protein kinase 14/0.449
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.449
2wouZZFTGF-beta receptor type-12.7.11.300.448
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.448
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.447
3kpkFADSulfide-quinone reductase/0.447
1rw8580TGF-beta receptor type-12.7.11.300.446
2p4yC03Peroxisome proliferator-activated receptor gamma/0.446
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.446
3ac2KSETyrosine-protein kinase Lck2.7.10.20.446
3to6LYS_CMCHistone acetyltransferase ESA1/0.446
4gk3L87Ephrin type-A receptor 32.7.10.10.446
4i231C9Epidermal growth factor receptor2.7.10.10.446
4kiq1RAMitogen-activated protein kinase 14/0.446
4nka2K7Fibroblast growth factor receptor 1/0.446
4xgiNADGlutamate dehydrogenase/0.446
1bygSTUTyrosine-protein kinase CSK/0.445
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
3sm2478Putative gag-pro-pol polyprotein/0.445
4g3jVNTLanosterol 14-alpha-demethylase/0.445
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.444
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.444
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.444
3gc9B45Mitogen-activated protein kinase 112.7.11.240.444
3hazFADBifunctional protein PutA/0.444
3iodA6DPantothenate synthetase6.3.2.10.444
3uhl2NCGag-Pol polyprotein3.4.23.160.444
1c6yMK1Protease/0.443
2vnaNAPProstaglandin reductase 21.3.1.480.443
2vww7X2Ephrin type-B receptor 42.7.10.10.443
3p4tFAOPutative acyl-CoA dehydrogenase/0.443
3t2zFADSulfide-quinone reductase/0.443
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.443
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.443
1ie4T44Transthyretin/0.442
2gstGPSGlutathione S-transferase Mu 12.5.1.180.442
2vwx7X4Ephrin type-B receptor 42.7.10.10.442
2xyuQ9GEphrin type-A receptor 42.7.10.10.442
2yn8STUEphrin type-B receptor 42.7.10.10.442
2zb3NDPProstaglandin reductase 21.3.1.480.442
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.442
3s4qNK0Mitogen-activated protein kinase 14/0.442
3tz3B36Acetyl-CoA carboxylase/0.442
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.442
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.442
1mesDMPGag-Pol polyprotein3.4.23.160.441
1mj9COAHistone acetyltransferase ESA1/0.441
2he5NDPAldo-keto reductase family 1 member C211.1.10.441
2of2547Tyrosine-protein kinase Lck2.7.10.20.441
2y05NAPProstaglandin reductase 1/0.441
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.441
3ea4FABAcetolactate synthase, chloroplastic2.2.1.60.441
3gxlQIGTGF-beta receptor type-12.7.11.300.441
3sz0FADSulfide-quinone reductase/0.441
3upjU03Gag-Pol polyprotein/0.441
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.441
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
4fehFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.441
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.441
1jpaANPEphrin type-B receptor 22.7.10.10.440
1u3dFADCryptochrome-1/0.440
1xddAAYIntegrin alpha-L/0.440
2g5cNADPrephenate dehydrogenase/0.440
4gk4L90Ephrin type-A receptor 32.7.10.10.440
4j54G52Gag-Pol polyprotein3.4.23.160.440