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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3b8q900Vascular endothelial growth factor receptor 22.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3b8q900Vascular endothelial growth factor receptor 22.7.10.11.000
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.698
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.574
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.567
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.558
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.555
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.555
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.547
2hyySTITyrosine-protein kinase ABL12.7.10.20.526
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.519
4o2z046Mitogen-activated protein kinase/0.519
1iepSTITyrosine-protein kinase ABL12.7.10.20.504
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.500
3efl706Vascular endothelial growth factor receptor 22.7.10.10.495
3hv5R24Mitogen-activated protein kinase 14/0.487
4aa0AA0Mitogen-activated protein kinase 14/0.487
3ctj320Hepatocyte growth factor receptor2.7.10.10.485
3hng8STVascular endothelial growth factor receptor 12.7.10.10.484
2og81N8Tyrosine-protein kinase Lck2.7.10.20.477
2p2i608Vascular endothelial growth factor receptor 22.7.10.10.477
3ce31FNHepatocyte growth factor receptor2.7.10.10.477
3kq7KQ7Mitogen-activated protein kinase 14/0.477
4qrc0LIFibroblast growth factor receptor 42.7.10.10.475
3eta351Insulin receptor2.7.10.10.472
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.467
4eyjN61Mitogen-activated protein kinase 132.7.11.240.465
2xir00JVascular endothelial growth factor receptor 22.7.10.10.463
4eevL1XHepatocyte growth factor receptor2.7.10.10.453
3vhkBPKVascular endothelial growth factor receptor 22.7.10.10.442