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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3b5iSAHIndole-3-acetate O-methyltransferase 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3b5iSAHIndole-3-acetate O-methyltransferase 1/1.000
2eg5SAH7-methylxanthosine synthase 1/0.515
3tylAXWNitric oxide synthase, brain1.14.13.390.471
4fvz4KJNitric oxide synthase, brain1.14.13.390.467
3c34KAIGlutamate receptor ionotropic, kainate 1/0.465
3c36KAIGlutamate receptor ionotropic, kainate 1/0.462
3nlw3XFNitric oxide synthase, brain1.14.13.390.461
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.457
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.456
4lwaQ13Nitric oxide synthase oxygenase1.14.13.1650.455
3b3pJI7Nitric oxide synthase, brain1.14.13.390.454
4k37SAMAnaerobic sulfatase-maturating enzyme1.8.980.454
3oafOAGDihydrofolate reductase1.5.1.30.449
1rs6DP2Nitric oxide synthase, brain1.14.13.390.448
4jseQJ2Nitric oxide synthase, brain1.14.13.390.448
4rtrSAMDNA adenine methylase2.1.1.720.447
3n66XFNNitric oxide synthase, brain1.14.13.390.446
4gbeSAHDNA adenine methylase2.1.1.720.446
3nlv3XANitric oxide synthase, brain1.14.13.390.445
4h3g10QBeta-secretase 13.4.23.460.444
4ug5XFKNitric oxide synthase oxygenase1.14.13.1650.444
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
3nlrJRSNitric oxide synthase, brain1.14.13.390.442
3dqrJI2Nitric oxide synthase, brain1.14.13.390.441
3n5yXFLNitric oxide synthase, brain1.14.13.390.441
4k5e1Q7Nitric oxide synthase, brain1.14.13.390.441
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4id9NADPutative UDP-glucose 4-epimerase/0.440