sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 1.000 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.770 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.764 | |
| 2eu3 | FF3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.753 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.751 | |
| 1g52 | F2B | Carbonic anhydrase 2 | 4.2.1.1 | 0.749 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.738 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.726 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.721 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.713 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.710 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.708 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.708 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.707 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.703 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.703 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.694 | |
| 1a42 | BZU | Carbonic anhydrase 2 | 4.2.1.1 | 0.693 | |
| 3f4x | KLT | Carbonic anhydrase 2 | 4.2.1.1 | 0.693 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.689 | |
| 3sax | E50 | Carbonic anhydrase 2 | 4.2.1.1 | 0.686 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.684 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.682 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.682 | |
| 1bn4 | AL9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.681 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.680 | |
| 1i8z | INL | Carbonic anhydrase 2 | 4.2.1.1 | 0.680 | |
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 | 0.680 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.679 | |
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 | 0.677 | |
| 3dd8 | 2C7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.675 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.673 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.673 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.669 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.663 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.659 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.659 | |
| 3sbi | E90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.659 | |
| 4iwz | 1GO | Carbonic anhydrase 2 | 4.2.1.1 | 0.659 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.659 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.657 | |
| 4kap | 1QV | Carbonic anhydrase 2 | 4.2.1.1 | 0.655 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.654 | |
| 4k13 | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.652 | |
| 3hku | TOR | Carbonic anhydrase 2 | 4.2.1.1 | 0.647 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.645 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.644 | |
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 | 0.643 | |
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.642 | |
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.637 | |
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.634 | |
| 3mhl | J71 | Carbonic anhydrase 2 | 4.2.1.1 | 0.634 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.632 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.631 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.629 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.629 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.627 | |
| 1i9n | IOA | Carbonic anhydrase 2 | 4.2.1.1 | 0.626 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.625 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.625 | |
| 3d9z | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.624 | |
| 4pxx | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.621 | |
| 3ni5 | C1H | Carbonic anhydrase 2 | 4.2.1.1 | 0.619 | |
| 4m2r | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.614 | |
| 4bf6 | X0Q | Carbonic anhydrase 2 | 4.2.1.1 | 0.614 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.614 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.612 | |
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 3v2j | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.608 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 1xpz | 4TZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 3mna | DWH | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 3dcc | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.605 | |
| 3mmf | D9H | Carbonic anhydrase 2 | 4.2.1.1 | 0.605 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 4m2v | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 2wej | FB2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.599 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.599 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.598 | |
| 4n16 | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.598 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.597 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.597 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.597 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.595 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.593 | |
| 3l14 | I7B | Carbonic anhydrase 2 | 4.2.1.1 | 0.592 | |
| 1cny | EG3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.591 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 3t84 | SG6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 1cnw | EG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.585 | |
| 2pow | I7C | Carbonic anhydrase 2 | 4.2.1.1 | 0.585 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.585 | |
| 3mhc | ARZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.582 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 2wd2 | MS5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.579 | |
| 3mzc | S6I | Carbonic anhydrase 2 | 4.2.1.1 | 0.579 | |
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 0.578 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.574 | |
| 3oys | OYS | Carbonic anhydrase 2 | 4.2.1.1 | 0.572 | |
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 | 0.572 | |
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.569 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.562 | |
| 3n0n | P9B | Carbonic anhydrase 2 | 4.2.1.1 | 0.561 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.559 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.556 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.555 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.555 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.551 | |
| 3n3j | WWV | Carbonic anhydrase 2 | 4.2.1.1 | 0.550 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.548 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.546 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.543 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.542 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.540 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.540 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.539 | |
| 1eou | SMS | Carbonic anhydrase 2 | 4.2.1.1 | 0.537 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.537 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.536 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.535 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.535 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.534 | |
| 3p5l | IT5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.533 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.533 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.531 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.531 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.530 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.530 | |
| 1i9p | IOE | Carbonic anhydrase 2 | 4.2.1.1 | 0.529 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.528 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.527 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.524 | |
| 2q1q | OSP | Carbonic anhydrase 2 | 4.2.1.1 | 0.523 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.518 | |
| 3oyq | OYQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.517 | |
| 4lu3 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.511 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.510 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.507 | |
| 1cnx | EG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.500 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.499 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.495 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.491 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.490 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.487 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.487 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.487 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.487 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.486 | |
| 4x5s | AZM | Carbonic anhydrase (Carbonate dehydratase) | / | 0.486 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.485 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.485 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.485 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.483 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.483 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.483 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.482 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.479 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.479 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.479 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.479 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.478 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.477 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.477 | |
| 1c7o | PPG | Hemolysin | / | 0.476 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.476 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.476 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.475 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.475 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.474 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.474 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.473 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.472 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.472 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.470 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.470 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.470 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.470 | |
| 4lut | DCS | Alanine racemase | / | 0.470 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.469 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.469 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.468 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.468 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.468 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.467 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.467 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.467 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.467 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.466 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.466 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.466 | |
| 2wzw | NDP | Nitroreductase NfnB | / | 0.466 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.465 | |
| 4wdg | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.465 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.464 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.464 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.464 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.464 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.464 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.463 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.463 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.463 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.463 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.463 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.463 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.463 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.462 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2qw0 | 34Z | 4-chlorobenzoyl CoA ligase | / | 0.462 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.462 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.462 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.460 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.460 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.459 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.459 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.459 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.459 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.458 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.458 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.458 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.458 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.458 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.457 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.457 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.457 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.457 | |
| 1s64 | 778 | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.457 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.457 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.457 | |
| 4ca8 | 3ES | Angiotensin-converting enzyme | 3.4.15.1 | 0.457 | |
| 5fl4 | 9FK | Carbonic anhydrase 9 | 4.2.1.1 | 0.457 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.456 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.456 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.456 | |
| 2xwe | AMF | Glucosylceramidase | 3.2.1.45 | 0.456 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.456 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.456 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.456 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.456 | |
| 4jic | FMN | GTN Reductase | / | 0.456 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.455 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.455 | |
| 3kru | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.455 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.455 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.454 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.454 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.454 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.454 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.454 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.454 | |
| 1ee9 | NAD | Methylenetetrahydrofolate dehydrogenase [NAD(+)] | 1.5.1.15 | 0.453 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.453 | |
| 1kw0 | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.453 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.453 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.453 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.453 | |
| 2po3 | T4K | 4-dehydrase | / | 0.453 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.453 | |
| 3b6p | TMP | Three-prime repair exonuclease 1 | 3.1.11.2 | 0.453 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.453 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.452 | |
| 1xag | NAD | 3-dehydroquinate synthase | / | 0.452 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.452 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.452 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.452 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4j4n | D44 | Peptidylprolyl isomerase | / | 0.452 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.452 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.451 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.451 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.451 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.451 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.451 | |
| 2wqp | WQP | Polysialic acid capsule biosynthesis protein SiaC | / | 0.451 | |
| 3ag6 | PAJ | Pantothenate synthetase | / | 0.451 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.451 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3x2e | NAI | Adenosylhomocysteinase | / | 0.451 | |
| 4knn | E1F | Carbonic anhydrase 13 | 4.2.1.1 | 0.451 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.450 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.450 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.450 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.449 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.449 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.449 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 3v2u | ATP | Protein GAL3 | / | 0.449 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.449 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4iah | 1DX | Alr2278 protein | / | 0.449 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.449 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.449 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.449 | |
| 4x2q | NAD | Retinal dehydrogenase 2 | 1.2.1.36 | 0.449 | |
| 1egd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.448 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.448 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.448 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.448 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.448 | |
| 3qfr | FMN | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.448 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.448 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.448 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.447 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.447 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.447 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.447 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.447 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.447 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.446 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.446 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.446 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.446 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.446 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.446 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.446 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.445 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.445 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.445 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.445 | |
| 4h0x | NAD | Iota toxin component Ia | / | 0.445 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.445 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.445 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.444 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.444 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.444 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.444 | |
| 1al8 | DHP | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.443 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.443 | |
| 2g0b | NLT | Long-chain N-acyl amino acid synthase | / | 0.443 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.443 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.443 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.443 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.443 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.443 | |
| 4hu1 | V13 | Carbonic anhydrase 13 | 4.2.1.1 | 0.443 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.443 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1el4 | CTZ | Obelin | / | 0.442 | |
| 1ivs | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.442 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.442 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.442 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.442 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.442 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.442 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.442 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.442 | |
| 3mdd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.442 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.442 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.442 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.442 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.441 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.441 | |
| 1s63 | 778 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 1uxy | EPU | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.441 | |
| 1vji | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.441 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.441 | |
| 2bn4 | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.441 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.441 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.441 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.441 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3kpb | SAM | Uncharacterized protein MJ0100 | / | 0.441 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.441 | |
| 3uu1 | 14B | Anthranilate phosphoribosyltransferase | / | 0.441 | |
| 3wag | TYD | Glycosyltransferase | / | 0.441 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.441 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4giu | 636 | Anthranilate phosphoribosyltransferase | / | 0.441 | |
| 4v12 | POG | MaoC like domain protein | / | 0.441 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.440 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.440 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.440 | |
| 2hve | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.440 | |
| 2q3r | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.440 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.440 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.440 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.440 | |
| 4hn1 | TYD | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.440 |