sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3b1j | NAD | Glyceraldehyde-3-phosphate dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3b1j | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 1.000 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.480 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.463 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.459 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.457 | |
| 2dr3 | ADP | UPF0273 protein PH0284 | / | 0.454 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.452 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.452 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.451 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.448 | |
| 2hck | QUE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.448 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.448 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.446 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.445 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.444 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.443 | |
| 2z6d | FMN | Phototropin-2 | 2.7.11.1 | 0.443 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.443 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.442 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.442 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.442 | |
| 1dvr | ATF | Adenylate kinase | / | 0.441 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.441 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.440 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.440 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.440 |