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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.579
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.506
4qmpDKISerine/threonine-protein kinase 242.7.11.10.474
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.467
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.464
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.462
4a6cQG9Gag-Pol polyprotein3.4.23.160.457
5dt0SKEAurora kinase A2.7.11.10.457
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.452
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.450
3lfqA28Cyclin-dependent kinase 22.7.11.220.450
1oitHDTCyclin-dependent kinase 22.7.11.220.449
3zptM8YGag-Pol polyprotein3.4.23.160.449
1t7j478Gag-Pol polyprotein3.4.23.160.448
3r7yZ04Cyclin-dependent kinase 22.7.11.220.448
1sguMK1Gag-Pol polyprotein3.4.23.160.447
4j95ACPFibroblast growth factor receptor 2/0.447
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.446
1di8DTQCyclin-dependent kinase 22.7.11.220.445
1npa3NHGag-Pol polyprotein3.4.23.160.445
1npwLGZGag-Pol polyprotein3.4.23.160.445
5dpvSKEAurora kinase A2.7.11.10.444
1e9hINRCyclin-dependent kinase 22.7.11.220.443
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.443
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2znnS44Peroxisome proliferator-activated receptor alpha/0.443
3rkb12ZCyclin-dependent kinase 22.7.11.220.443
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.443
1ppm0P1Penicillopepsin-13.4.23.200.442
2bb9AKCGag-Pol polyprotein3.4.23.160.442
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.442
2qnqQN3Gag-Pol polyprotein3.4.23.160.442
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.442
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.442
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.440