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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ai3NDPNADPH-sorbose reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ai3NDPNADPH-sorbose reductase/1.000
3ai2NDPNADPH-sorbose reductase/0.696
3lqfNADGalactitol dehydrogenase/0.504
4hwkNAPSepiapterin reductase1.1.1.1530.504
4j7uNAPSepiapterin reductase1.1.1.1530.500
3toxNAPPutative oxidoreductase/0.499
4qecNAPElxO/0.499
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.498
1ipeNDPTropinone reductase 21.1.1.2360.491
4j7xNAPSepiapterin reductase1.1.1.1530.488
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.487
1xkqNDPUncharacterized protein/0.486
1xg5NAPDehydrogenase/reductase SDR family member 11/0.485
1w4zNAPPutative ketoacyl reductase1.3.10.484
4esoNAPPutative oxidoreductase/0.484
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.483
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.479
1ae1NAPTropinone reductase 1/0.478
5idwNAPShort-chain dehydrogenase/reductase SDR/0.478
3p19NDPPutative blue fluorescent protein/0.473
3gy0NAPNAD(P)-dependent oxidoreductase/0.472
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.470
3f1kNAPUncharacterized oxidoreductase YciK10.470
4nbwNADShort-chain dehydrogenase/reductase SDR/0.470
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.469
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.468
1g6kNADGlucose 1-dehydrogenase1.1.1.470.465
1x7hNDPPutative ketoacyl reductase1.3.10.464
4bmvNAPShort-chain dehydrogenase/0.464
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.464
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.461
2bd0NAPSepiapterin reductase/0.460
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.459
1n5dNDPCarbonyl reductase [NADPH] 1/0.458
4b79NADProbable short-chain dehydrogenase/0.458
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
4qedNAPElxO/0.457
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.456
2yutNAPPutative short-chain oxidoreductase/0.455
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
3l77NJPShort-chain alcohol dehydrogenase/0.454
3qrwNDPPutative ketoacyl reductase1.3.10.453
3tn7NJPShort-chain alcohol dehydrogenase/0.451
1x7gNAPPutative ketoacyl reductase1.3.10.450
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.448
2jahNDPClavaldehyde dehydrogenase/0.445
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.445
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.444
3uceNDPDehydrogenase/0.444
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.443
5jlaNADPutative short-chain dehydrogenase/reductase/0.443
3vdqNAD3-hydroxybutyrate dehydrogenase/0.440