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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3a99ANPSerine/threonine-protein kinase pim-12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3a99ANPSerine/threonine-protein kinase pim-12.7.11.11.000
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.564
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.541
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.525
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.519
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.518
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.510
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.509
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.500
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.481
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.477
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.477
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.476
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.474
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.473
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.473
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.472
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.470
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.467
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.467
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.467
3bqr4RBDeath-associated protein kinase 3/0.466
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.462
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.462
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.461
1xjdSTUProtein kinase C theta type2.7.11.130.460
4qnyANPMitogen activated protein kinase, putative/0.460
5av2KMPDeath-associated protein kinase 12.7.11.10.460
2ckeIQUDeath-associated protein kinase 2/0.459
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.459
3umw596Serine/threonine-protein kinase pim-12.7.11.10.458
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
4ez50RSCyclin-dependent kinase 62.7.11.220.457
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.456
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.456
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.456
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.456
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.454
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.454
3bu5ATPInsulin receptor2.7.10.10.452
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.451
2izrBRKCasein kinase I isoform gamma-32.7.11.10.450
1jklANPDeath-associated protein kinase 12.7.11.10.449
2hog710Serine/threonine-protein kinase Chk12.7.11.10.449
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.449
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.449
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3gu7ADPDeath-associated protein kinase 12.7.11.10.448
1wvxBD4Death-associated protein kinase 12.7.11.10.447
4jr7GNPCasein kinase II subunit alpha2.7.11.10.447
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.446
3zh8C58Protein kinase C iota type2.7.11.130.446
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.446
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.445
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
4xlvACPInsulin receptor2.7.10.10.445
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.444
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.444
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.443
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3gc9B45Mitogen-activated protein kinase 112.7.11.240.443
4ic7ANPMitogen-activated protein kinase 72.7.11.240.443
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.442
1yvj4STTyrosine-protein kinase JAK32.7.10.20.442
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.442
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.442
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.441
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.441
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.441
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.441
3c4zADPRhodopsin kinase/0.440
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.440
5awmANPStress-activated protein kinase JNK2.7.11.240.440