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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3a6pGTPGTP-binding nuclear protein Ran

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3a6pGTPGTP-binding nuclear protein Ran/1.000
3bbpGTPRas-related protein Rab-6A/0.610
3w3zGTPGTP-binding nuclear protein Ran/0.610
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.607
5dhaGNPGTP-binding nuclear protein Ran/0.606
4ol0GTPGTP-binding nuclear protein Ran/0.599
3ea5GDPGTP-binding nuclear protein Ran/0.597
1zbdGTPRas-related protein Rab-3A/0.595
2gilGTPRas-related protein Rab-6A/0.590
3lbnGNPGTPase HRas/0.578
1xtsGTPGTP-binding protein Rheb/0.577
3e5hGNPRas-related protein Rab-28/0.577
1k5dGNPGTP-binding nuclear protein Ran/0.575
4mitGTPRho-related protein racC/0.569
5jljGNPGTP-binding nuclear protein Ran/0.567
1xtrGNPGTP-binding protein Rheb/0.561
2rgcGNPGTPase HRas/0.561
1yhnGTPRas-related protein Rab-7a/0.560
2bkuGTPGTP-binding nuclear protein Ran/0.557
1t91GTPRas-related protein Rab-7a/0.553
3oiuGNPGTPase HRas/0.552
2rgeGNPGTPase HRas/0.551
1yzqGNPRas-related protein Rab-6A/0.550
3nbzGTPGTP-binding nuclear protein Ran/0.546
2fe4GDPRas-related protein Rab-6B/0.544
3a58GNPGTP-binding protein RHO1/0.544
4rkfGNPRas-related protein Rab-3/0.544
3rs7GNPGTPase HRas/0.542
3rabGNPRas-related protein Rab-3A/0.541
2zetGTPRas-related protein Rab-27B/0.539
3lawGNPRas-related protein Rab-7a/0.538
1ibrGNPGTP-binding nuclear protein Ran/0.536
4nyiGNPGTPase HRas/0.536
5difGNPGTP-binding nuclear protein Ran/0.536
3tnfGNPRas-related protein Rab-8A/0.535
4nyjGNPGTPase HRas/0.534
5b2zGNPGTPase HRas/0.534
3kucGDPRas-related protein Rap-1A/0.532
3oesGNPGTPase RhebL1/0.532
1zd9GDPADP-ribosylation factor-like protein 8A/0.530
4k81GTPGTPase HRas/0.530
3pitGNPRas-related protein M-Ras/0.529
4qxaGTPRas-related protein Rab-9A/0.529
3v4fGNPGTPase HRas/0.528
4dlwGNPGTPase HRas/0.528
3tsoGNPRas-related protein Rab-25/0.525
3rs0GNPGTPase HRas/0.523
1kmqGNPTransforming protein RhoA/0.522
4o2rGDPGTP-binding protein Rheb/0.521
4hdoGNPRas-related protein Rap-1b/0.519
4lhwGNPRas-related protein Rab-8A/0.519
3i3sGNPGTPase HRas/0.518
4dlzGNPGTPase HRas/0.518
1g17GNPRas-related protein SEC4/0.517
3ddcGNPGTPase HRas/0.516
3rs5GNPGTPase HRas/0.516
1e96GTPRas-related C3 botulinum toxin substrate 1/0.515
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.515
3x1zGNPRas-related protein Rap-1b/0.515
4g0nGNPGTPase HRas/0.515
4dltGNPGTPase HRas/0.514
4o25GTPGTP-binding protein Rheb/0.514
3l8yGNPGTPase HRas/0.513
3oivGNPGTPase HRas/0.513
3wyfGTPGTP-binding nuclear protein/0.513
4dlxGNPGTPase HRas/0.512
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.511
1oixGDPRas-related protein Rab-11A/0.508
2gcpGSPRho-related GTP-binding protein RhoC/0.508
3kkoGNPRas-related protein M-Ras/0.508
3oiwGNPGTPase HRas/0.508
4dsnGCPGTPase KRas/0.507
1vg8GNPRas-related protein Rab-7a/0.506
3lbhGNPGTPase HRas/0.506
4cymGCPRas-related protein Rab-32/0.506
2ffqGSPRas-related protein Rab-6B/0.505
3kz1GSPTransforming protein RhoA/0.504
1g16GDPRas-related protein SEC4/0.501
3rslGNPGTPase HRas/0.501
3rs4GNPGTPase HRas/0.500
4xoiGTPTransforming protein RhoA/0.498
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.497
4uj3GNPRas-related protein Rab-11A/0.496
3k8yGNPGTPase HRas/0.495
1a2bGSPTransforming protein RhoA/0.491
2c5lGTPGTPase HRas/0.490
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.490
1cxzGSPTransforming protein RhoA/0.489
4o2lGTPGTP-binding protein Rheb/0.489
3lbiGNPGTPase HRas/0.488
4dlsGNPGTPase HRas/0.486
2msdGNPMHC class I alpha chain/0.485
1s1cGNPTransforming protein RhoA/0.484
3bc1GNPRas-related protein Rab-27A/0.484
3kudGDPGTPase HRas/0.484
1ow3GDPTransforming protein RhoA/0.480
3qbtGNPRas-related protein Rab-8A/0.479
4js0GNPCell division control protein 42 homolog/0.475
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.473
4l9wGNPGTPase HRas/0.473
2rggGNPGTPase HRas/0.472
5hpyGDPTransforming protein RhoA/0.471
1m7bGTPRho-related GTP-binding protein RhoE/0.470
3tklGTPRas-related protein Rab-1A/0.470
4dsoGSPGTPase KRas/0.470
3mjhGTPRas-related protein Rab-5A/0.468
4dlvGNPGTPase HRas/0.468
4ql3GDPGTPase KRas/0.468
1x1rGDPRas-related protein M-Ras/0.465
4tq9GDPGTPase KRas/0.465
1z2aGDPRas-related protein Rab-23/0.464
1zc4GNPRas-related protein Ral-A/0.463
4hdqGNPRas-related protein Rap-1b/0.463
1n6lGTPRas-related protein Rab-5A/0.462
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.462
3eg5GNPCell division control protein 42 homolog/0.462
4kvgGTPRas-related protein Rap-1A/0.462
1d5cGDPGTPase (Rab6)/0.460
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.460
3c14GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.460
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.460
2clsGTPRho-related GTP-binding protein Rho6/0.459
1zc3GNPRas-related protein Ral-A/0.458
4l9sGDPGTPase HRas/0.458
3cphGDPRas-related protein SEC4/0.456
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.455
2rgbGNPGTPase HRas/0.455
4lucGDPGTPase KRas/0.455
4xvrGNPGTPase HRas/0.455
1u0hGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.453
1cs4GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.452
4uj5GNPRas-related protein Rab-11A/0.448
1tu3GNPRas-related protein Rab-5A/0.447
4cidANPEH domain-containing protein 2/0.446
2j5xGSPADP-ribosylation factor 6/0.445
4epxGDPGTPase KRas/0.444
4q03GDPGTPase KRas/0.442
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.441
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.441