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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3a5oATPMajor actin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3a5oATPMajor actin/1.000
3el2ATPActin-5C/0.625
4pkiATPActin, alpha skeletal muscle/0.625
1kxpATPActin, alpha skeletal muscle/0.597
2q36ATPActin, alpha skeletal muscle/0.595
1mduATPActin, alpha skeletal muscle/0.589
1t44ATPActin, alpha skeletal muscle/0.586
4k42ADPActin, alpha skeletal muscle/0.583
1c0fATPMajor actin/0.579
3a5mATPMajor actin/0.579
4pkhADPActin, alpha skeletal muscle/0.579
1dejATPMajor actin/0.577
3m6gATPActin, alpha skeletal muscle/0.577
1nmdATPMajor actin/0.576
1lotATPActin, alpha skeletal muscle/0.574
1rgiATPActin, alpha skeletal muscle/0.573
4pkgATPActin, alpha skeletal muscle/0.569
1eqyATPActin, alpha skeletal muscle/0.566
3tu5ATPActin, alpha skeletal muscle/0.566
3m1fATPActin, alpha skeletal muscle/0.561
4k41ATPActin, alpha skeletal muscle/0.559
5ce3ATPActin/0.559
3mn6ATPActin-5C/0.555
1h1vATPActin, alpha skeletal muscle/0.554
1nm1ATPMajor actin/0.554
4pl8ATPActin, alpha skeletal muscle/0.548
4cbxATPActin-2/0.546
2a41ATPActin, alpha skeletal muscle/0.543
1ijjATPActin, alpha skeletal muscle/0.541
1s22ATPActin, alpha skeletal muscle/0.540
3u9dATPActin, alpha skeletal muscle/0.539
3w3dATPActin, gamma-enteric smooth muscle/0.536
1yxqATPActin, alpha skeletal muscle/0.534
4k43ADPActin, alpha skeletal muscle/0.532
3ffkATPActin, alpha skeletal muscle/0.530
3mn7ATPActin-5C/0.530
4m63ATPActin-5C/0.529
4ci6ATPActin/0.527
2p9kATPActin-related protein 2/0.526
3u4lATPActin, cytoplasmic 1/0.526
4jhdANPActin-5C/0.522
2q97ATPActin, alpha skeletal muscle/0.520
3mn9ATPActin-5C/0.518
3dawATPActin, alpha skeletal muscle/0.515
2v51ATPActin, alpha skeletal muscle/0.508
3eksATPActin-5C/0.505
1qz5ATPActin, alpha skeletal muscle/0.499
2oanATPActin, cytoplasmic 1/0.499
4rwtANPActin-5C/0.472
4dpwAGSMevalonate diphosphate decarboxylase/0.456