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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3a5mATPMajor actin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3a5mATPMajor actin/1.000
4jhdANPActin-5C/0.573
1nm1ATPMajor actin/0.557
4k42ADPActin, alpha skeletal muscle/0.555
1nmdATPMajor actin/0.551
1yxqATPActin, alpha skeletal muscle/0.550
1s22ATPActin, alpha skeletal muscle/0.547
5ce3ATPActin/0.544
1ijjATPActin, alpha skeletal muscle/0.539
1t44ATPActin, alpha skeletal muscle/0.533
4k43ADPActin, alpha skeletal muscle/0.532
1lotATPActin, alpha skeletal muscle/0.531
1c0fATPMajor actin/0.530
4pl8ATPActin, alpha skeletal muscle/0.530
3mn6ATPActin-5C/0.529
2v51ATPActin, alpha skeletal muscle/0.528
4pkhADPActin, alpha skeletal muscle/0.528
3ffkATPActin, alpha skeletal muscle/0.527
4pkgATPActin, alpha skeletal muscle/0.527
1rgiATPActin, alpha skeletal muscle/0.526
3u9dATPActin, alpha skeletal muscle/0.524
3m6gATPActin, alpha skeletal muscle/0.522
4rwtANPActin-5C/0.522
1h1vATPActin, alpha skeletal muscle/0.519
3el2ATPActin-5C/0.517
4m63ATPActin-5C/0.513
2q36ATPActin, alpha skeletal muscle/0.511
3mn9ATPActin-5C/0.508
3tu5ATPActin, alpha skeletal muscle/0.508
4ci6ATPActin/0.507
1qz5ATPActin, alpha skeletal muscle/0.505
4cbxATPActin-2/0.497
2q97ATPActin, alpha skeletal muscle/0.494
2p9kATPActin-related protein 2/0.490
3dawATPActin, alpha skeletal muscle/0.490
3mn7ATPActin-5C/0.488
4k41ATPActin, alpha skeletal muscle/0.488
1eqyATPActin, alpha skeletal muscle/0.481
3u4lATPActin, cytoplasmic 1/0.474
1kxpATPActin, alpha skeletal muscle/0.473
4pkiATPActin, alpha skeletal muscle/0.471
3m1fATPActin, alpha skeletal muscle/0.468
2oanATPActin, cytoplasmic 1/0.467
3chwATPMajor actin/0.464
3eksATPActin-5C/0.463
1mduATPActin, alpha skeletal muscle/0.458
1nlvATPMajor actin/0.455
3a5oATPMajor actin/0.454