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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3a58GNPGTP-binding protein RHO1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3a58GNPGTP-binding protein RHO1/1.000
1cxzGSPTransforming protein RhoA/0.572
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.563
1kmqGNPTransforming protein RhoA/0.557
1g17GNPRas-related protein SEC4/0.554
1a2bGSPTransforming protein RhoA/0.551
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.549
2gcpGSPRho-related GTP-binding protein RhoC/0.544
1e96GTPRas-related C3 botulinum toxin substrate 1/0.539
3kz1GSPTransforming protein RhoA/0.539
3w3zGTPGTP-binding nuclear protein Ran/0.538
1yzqGNPRas-related protein Rab-6A/0.536
4mitGTPRho-related protein racC/0.536
3a6pGTPGTP-binding nuclear protein Ran/0.532
3e5hGNPRas-related protein Rab-28/0.530
3nbzGTPGTP-binding nuclear protein Ran/0.529
1s1cGNPTransforming protein RhoA/0.528
2clsGTPRho-related GTP-binding protein Rho6/0.528
5dhaGNPGTP-binding nuclear protein Ran/0.528
1zbdGTPRas-related protein Rab-3A/0.527
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.527
1t91GTPRas-related protein Rab-7a/0.524
3eg5GNPCell division control protein 42 homolog/0.523
2gilGTPRas-related protein Rab-6A/0.521
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.519
3bbpGTPRas-related protein Rab-6A/0.518
4nyiGNPGTPase HRas/0.518
1m7bGTPRho-related GTP-binding protein RhoE/0.517
3oesGNPGTPase RhebL1/0.511
4nyjGNPGTPase HRas/0.510
4ol0GTPGTP-binding nuclear protein Ran/0.508
1xtsGTPGTP-binding protein Rheb/0.506
4xoiGTPTransforming protein RhoA/0.505
1yhnGTPRas-related protein Rab-7a/0.501
4dltGNPGTPase HRas/0.501
4js0GNPCell division control protein 42 homolog/0.501
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.500
4kvgGTPRas-related protein Rap-1A/0.498
3i3sGNPGTPase HRas/0.496
3lbnGNPGTPase HRas/0.496
3v4fGNPGTPase HRas/0.495
1z2cGNPRho-related GTP-binding protein RhoC/0.494
4k81GTPGTPase HRas/0.493
3kucGDPRas-related protein Rap-1A/0.492
4cymGCPRas-related protein Rab-32/0.490
3oivGNPGTPase HRas/0.489
3tnfGNPRas-related protein Rab-8A/0.489
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.488
1zc4GNPRas-related protein Ral-A/0.485
2c5lGTPGTPase HRas/0.485
2zetGTPRas-related protein Rab-27B/0.484
3rs7GNPGTPase HRas/0.481
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.480
1vg8GNPRas-related protein Rab-7a/0.480
3l8yGNPGTPase HRas/0.480
3oiuGNPGTPase HRas/0.479
2bkuGTPGTP-binding nuclear protein Ran/0.478
1zc3GNPRas-related protein Ral-A/0.477
3ddcGNPGTPase HRas/0.476
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.476
4hdoGNPRas-related protein Rap-1b/0.475
1ibrGNPGTP-binding nuclear protein Ran/0.474
3lbiGNPGTPase HRas/0.474
5hpyGDPTransforming protein RhoA/0.474
1xtrGNPGTP-binding protein Rheb/0.472
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.471
2ffqGSPRas-related protein Rab-6B/0.470
2rgbGNPGTPase HRas/0.470
3lbhGNPGTPase HRas/0.470
4g0nGNPGTPase HRas/0.469
3kkoGNPRas-related protein M-Ras/0.468
3lawGNPRas-related protein Rab-7a/0.468
1ow3GDPTransforming protein RhoA/0.467
3rs4GNPGTPase HRas/0.466
4dsnGCPGTPase KRas/0.466
4dsoGSPGTPase KRas/0.466
5b2zGNPGTPase HRas/0.466
2rgeGNPGTPase HRas/0.465
3th5GNPRas-related C3 botulinum toxin substrate 1/0.464
2fe4GDPRas-related protein Rab-6B/0.463
3tklGTPRas-related protein Rab-1A/0.463
4dlwGNPGTPase HRas/0.463
1gwnGTPRho-related GTP-binding protein RhoE/0.461
4rkfGNPRas-related protein Rab-3/0.460
3ea5GDPGTP-binding nuclear protein Ran/0.457
3oiwGNPGTPase HRas/0.454
4o25GTPGTP-binding protein Rheb/0.453
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.452
4lhwGNPRas-related protein Rab-8A/0.450
2rgcGNPGTPase HRas/0.449
4dvgGSPRho family GTPase/0.449
5difGNPGTP-binding nuclear protein Ran/0.449
5jljGNPGTP-binding nuclear protein Ran/0.448
3pitGNPRas-related protein M-Ras/0.447
3rabGNPRas-related protein Rab-3A/0.447
3kudGDPGTPase HRas/0.446
3x1zGNPRas-related protein Rap-1b/0.446
4bgbADPPredicted molecular chaperone distantly related to HSP70-fold metalloproteases/0.446
4hdqGNPRas-related protein Rap-1b/0.446
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.445
2msdGNPMHC class I alpha chain/0.444
3rs5GNPGTPase HRas/0.442
3bc1GNPRas-related protein Rab-27A/0.440
4qxaGTPRas-related protein Rab-9A/0.440