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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3a4vNADNDP-sugar epimerase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3a4vNADNDP-sugar epimerase/1.000
3a1nNADNDP-sugar epimerase/0.711
3a9wNADNDP-sugar epimerase/0.556
5lc1NADL-threonine 3-dehydrogenase/0.538
3ajrNADNDP-sugar epimerase/0.534
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.511
2yy7NADL-threonine dehydrogenase/0.492
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.482
2wsbNADGalactitol dehydrogenase/0.481
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.479
3rj9NADAlcohol dehydrogenase1.1.1.10.476
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.475
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.471
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.470
2p5uNADUDP-glucose 4-epimerase/0.470
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.469
1mg5NAIAlcohol dehydrogenase1.1.1.10.469
3d3wNAPL-xylulose reductase1.1.1.100.468
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.465
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.465
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.464
1wntNAPL-xylulose reductase1.1.1.100.464
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.463
3rj5NADAlcohol dehydrogenase1.1.1.10.463
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.463
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.462
1b15NAEAlcohol dehydrogenase1.1.1.10.460
1pr9NAPL-xylulose reductase1.1.1.100.460
3ak4NADNADH-dependent quinuclidinone reductase/0.459
2dteNAIGlucose 1-dehydrogenase related protein/0.458
4gh5NADShort-chain dehydrogenase/reductase SDR/0.458
5jlaNADPutative short-chain dehydrogenase/reductase/0.458
1b16NAQAlcohol dehydrogenase1.1.1.10.455
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.454
3wmxNADNAD dependent epimerase/dehydratase/0.454
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.453
4nbwNADShort-chain dehydrogenase/reductase SDR/0.452
1iy8NADLevodione reductase/0.451
1sbyNADAlcohol dehydrogenase1.1.1.10.450
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.449
4egbNADdTDP-glucose 4,6-dehydratase/0.449
2aa3AP0L-lactate dehydrogenase/0.448
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.447
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.446
1z7eATPBifunctional polymyxin resistance protein ArnA/0.445
2wdzNADGalactitol dehydrogenase/0.445
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.445
1zemNADXylitol dehydrogenase/0.444
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.443
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.443
3wdsNADNADH-dependent quinuclidinone reductase/0.443
2yutNAPPutative short-chain oxidoreductase/0.442
3uxyNADShort-chain dehydrogenase/reductase SDR/0.442
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.440
4qecNAPElxO/0.440