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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3a4oSTUTyrosine-protein kinase Lyn2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3a4oSTUTyrosine-protein kinase Lyn2.7.10.21.000
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.561
3zewSTUEphrin type-B receptor 42.7.10.10.555
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.531
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.530
4gk4L90Ephrin type-A receptor 32.7.10.10.515
3uvqFS8Mitogen-activated protein kinase 14/0.512
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.511
1bygSTUTyrosine-protein kinase CSK/0.507
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.507
4j95ACPFibroblast growth factor receptor 2/0.507
3gc9B45Mitogen-activated protein kinase 112.7.11.240.506
4gk3L87Ephrin type-A receptor 32.7.10.10.506
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.505
4jia1K3Tyrosine-protein kinase JAK2/0.503
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.502
2hk51BMTyrosine-protein kinase HCK2.7.10.20.500
2of2547Tyrosine-protein kinase Lck2.7.10.20.500
3vjoANPEpidermal growth factor receptor2.7.10.10.500
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.497
4gk2L66Ephrin type-A receptor 32.7.10.10.497
2of4979Tyrosine-protein kinase Lck2.7.10.20.496
2itqITQEpidermal growth factor receptor2.7.10.10.495
4id71G0Activated CDC42 kinase 1/0.495
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.494
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.492
2xvdAS6Ephrin type-B receptor 42.7.10.10.490
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.490
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.490
2itnANPEpidermal growth factor receptor2.7.10.10.488
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.486
2eb3ANPEpidermal growth factor receptor2.7.10.10.486
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.486
4c57FEFCyclin-G-associated kinase2.7.11.10.485
4gmy0X5Tyrosine-protein kinase JAK2/0.484
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.484
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.484
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.483
2qoqANPEphrin type-A receptor 32.7.10.10.482
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.482
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.481
4bcmT7ZCyclin-dependent kinase 22.7.11.220.481
4jq8KJ8Epidermal growth factor receptor2.7.10.10.481
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.481
1u54ACPActivated CDC42 kinase 1/0.480
2qo9ANPEphrin type-A receptor 32.7.10.10.479
4ic7ANPMitogen-activated protein kinase 72.7.11.240.479
2henADPEphrin type-B receptor 22.7.10.10.478
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.478
2yn8STUEphrin type-B receptor 42.7.10.10.477
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.477
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.476
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.476
5e8wSTUTGF-beta receptor type-12.7.11.300.476
2xyuQ9GEphrin type-A receptor 42.7.10.10.475
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.475
2ittAEEEpidermal growth factor receptor2.7.10.10.473
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.473
2hog710Serine/threonine-protein kinase Chk12.7.11.10.472
4riyADPEpidermal growth factor receptor2.7.10.10.472
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.472
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.471
3w0pADPHygromycin-B 4-O-kinase2.7.1.1630.471
4fv9E71Mitogen-activated protein kinase 12.7.11.240.471
4j99ACPFibroblast growth factor receptor 2/0.471
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.471
2itvANPEpidermal growth factor receptor2.7.10.10.470
3ac2KSETyrosine-protein kinase Lck2.7.10.20.470
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.470
3t8oATPRhodopsin kinase/0.470
1m17AQ4Epidermal growth factor receptor2.7.10.10.469
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.469
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.469
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.469
4grb0XGCasein kinase II subunit alpha2.7.11.10.469
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.468
2itwITQEpidermal growth factor receptor2.7.10.10.468
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.468
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.468
3w2sW2REpidermal growth factor receptor2.7.10.10.468
4i231C9Epidermal growth factor receptor2.7.10.10.468
3i60E86Mitogen-activated protein kinase 12.7.11.240.467
4bbe3O4Tyrosine-protein kinase JAK2/0.467
2x9fX9FEphrin type-B receptor 42.7.10.10.466
2zybKSLTyrosine-protein kinase Lck2.7.10.20.466
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.466
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.465
2j7t274Serine/threonine-protein kinase 102.7.11.10.465
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.465
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.465
3mtfA3FActivin receptor type-12.7.11.300.465
3zh8C58Protein kinase C iota type2.7.11.130.465
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.465
2x6dX6DAurora kinase A2.7.11.10.464
4wkqIREEpidermal growth factor receptor2.7.10.10.464
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.463
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.463
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
2j0m4STFocal adhesion kinase 12.7.10.20.462
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.462
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.462
5e8ySTUTGF-beta receptor type-22.7.11.300.462
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.461
2itxANPEpidermal growth factor receptor2.7.10.10.461
2vn0TDZCytochrome P450 2C8/0.461
2vwx7X4Ephrin type-B receptor 42.7.10.10.461
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.461
4j97ACPFibroblast growth factor receptor 2/0.461
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.460
2vwu7X1Ephrin type-B receptor 42.7.10.10.460
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.460
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.460
4nka2K7Fibroblast growth factor receptor 1/0.460
1zrzBI1Protein kinase C iota type2.7.11.130.459
3a7hATPSerine/threonine-protein kinase 242.7.11.10.459
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4hvi19STyrosine-protein kinase JAK32.7.10.20.459
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.459
1py5PY1TGF-beta receptor type-12.7.11.300.458
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
4c58824Cyclin-G-associated kinase2.7.11.10.458
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.458
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
1mqbANPEphrin type-A receptor 22.7.10.10.457
4f640S8Fibroblast growth factor receptor 1/0.457
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.457
3ac1KZITyrosine-protein kinase Lck2.7.10.20.456
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.456
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.456
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.455
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.455
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.455
3gxlQIGTGF-beta receptor type-12.7.11.300.455
3oom507Activin receptor type-12.7.11.300.455
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.455
4jr3KJREpidermal growth factor receptor2.7.10.10.455
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.454
2g2fAGSTyrosine-protein kinase ABL12.7.10.20.454
2ituITQEpidermal growth factor receptor2.7.10.10.454
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.454
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.454
1pjkANPCasein kinase II subunit alpha2.7.11.10.453
2c6eHPMAurora kinase A2.7.11.10.453
2qocANPEphrin type-A receptor 32.7.10.10.453
2vd5BI8Myotonin-protein kinase2.7.11.10.453
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.453
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.453
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.452
3w0nANPHygromycin-B 4-O-kinase2.7.1.1630.452
4e730NRMitogen-activated protein kinase 82.7.11.240.452
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.452
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4hgs15GCasein kinase I isoform gamma-32.7.11.10.451
4hvh19RTyrosine-protein kinase JAK32.7.10.20.451
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.451
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.450
4fuxE75Mitogen-activated protein kinase 12.7.11.240.450
4k33ACPFibroblast growth factor receptor 32.7.10.10.450
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.449
4c4h7RODual specificity protein kinase TTK2.7.12.10.449
4izy1J2Mitogen-activated protein kinase 82.7.11.240.449
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
2vu3LZECyclin-dependent kinase 22.7.11.220.448
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.448
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
3s4qNK0Mitogen-activated protein kinase 14/0.448
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.448
4g2fC07Ephrin type-A receptor 32.7.10.10.448
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.448
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.447
3vs3VSETyrosine-protein kinase HCK2.7.10.20.447
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.447
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.447
4hyu1BKMitogen-activated protein kinase 82.7.11.240.447
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
4y93746Tyrosine-protein kinase/0.447
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.446
2izsBRQCasein kinase I isoform gamma-32.7.11.10.446
2qo7ANPEphrin type-A receptor 32.7.10.10.446
3at4CCKCasein kinase II subunit alpha2.7.11.10.446
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.446
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.446
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
5e8xSTUTGF-beta receptor type-12.7.11.300.446
5eg3ACPFibroblast growth factor receptor 2/0.446
1pmn984Mitogen-activated protein kinase 102.7.11.240.445
1yvj4STTyrosine-protein kinase JAK32.7.10.20.445
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.445
3bqr4RBDeath-associated protein kinase 3/0.445
3d7tSTUTyrosine-protein kinase CSK/0.445
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.445
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.445
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
2xp2VGHALK tyrosine kinase receptor2.7.10.10.444
3nwq2NCGag-Pol polyprotein3.4.23.160.444
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.444
4aguD15Cyclin-dependent kinase-like 1/0.444
4bgg844Activin receptor type-12.7.11.300.444
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.444
4nks2M2Fibroblast growth factor receptor 1/0.444
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.444
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.444
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
3lu8IQXSerum albumin/0.443
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.443
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.443
4g1wG1WMitogen-activated protein kinase 82.7.11.240.443
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.443
4ji91M3Tyrosine-protein kinase JAK2/0.443
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1xddAAYIntegrin alpha-L/0.442
3c4xATPRhodopsin kinase/0.442
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.442
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.441
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.441
3igoANPCalmodulin-domain protein kinase 1, putative/0.441
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.441
3t113T1Gag-Pol polyprotein3.4.23.160.441
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
4c59FEFCyclin-G-associated kinase2.7.11.10.441
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.441
4y95746Tyrosine-protein kinase/0.441
2izrBRKCasein kinase I isoform gamma-32.7.11.10.440
2j0lANPFocal adhesion kinase 12.7.10.20.440
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.440
2zjwREFCasein kinase II subunit alpha2.7.11.10.440
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.440
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.440
4j98ACPFibroblast growth factor receptor 2/0.440
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440