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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3a3yOBNSodium/potassium-transporting ATPase subunit alpha

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3a3yOBNSodium/potassium-transporting ATPase subunit alpha/1.000
4oztP1AEcdysone receptor, putative/0.492
4g7gVFVLanosterol 14-alpha-demethylase/0.474
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.472
3gw9VNILanosterol 14-alpha-demethylase/0.470
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.469
1ahiCHO7-alpha-hydroxysteroid dehydrogenase1.1.1.1590.466
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.463
3r9uFADThioredoxin reductase/0.461
3tk3CPZCytochrome P450 2B41.14.14.10.461
4g3jVNTLanosterol 14-alpha-demethylase/0.461
3adaNADSubunit alpha of sarocosine oxidase/0.460
1pdhFASp-hydroxybenzoate hydroxylase/0.458
4uymVOR14-alpha sterol demethylase Cyp51B/0.458
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.457
1xddAAYIntegrin alpha-L/0.456
4bb3KKAIsopenicillin N synthase1.21.3.10.456
1kkq471Peroxisome proliferator-activated receptor alpha/0.455
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.455
4b1rITCTetracycline repressor protein class D/0.455
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
3lqfNADGalactitol dehydrogenase/0.454
2npaMMBPeroxisome proliferator-activated receptor alpha/0.453
1fmlRTLRetinol dehydratase/0.452
2znq401Peroxisome proliferator-activated receptor delta/0.452
1xe55FEPlasmepsin-23.4.23.390.451
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
3qlrNDPDihydrofolate reductase1.5.1.30.451
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.450
3jynNDPQuinone oxidoreductase/0.450
4enhFVXCholesterol 24-hydroxylase/0.450
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.450
1fm9570Peroxisome proliferator-activated receptor gamma/0.449
1k6tXN1Gag-Pol polyprotein3.4.23.160.449
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.448
4q73FADBifunctional protein PutA/0.448
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.447
1qiqACCIsopenicillin N synthase1.21.3.10.447
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
3sz0FADSulfide-quinone reductase/0.447
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.447
4q72FADBifunctional protein PutA/0.447
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.447
2d29FADAcyl-CoA dehydrogenase/0.446
2p1v5TNRetinoic acid receptor RXR-alpha/0.446
1ma0NADAlcohol dehydrogenase class-31.1.1.10.445
2ath3EAPeroxisome proliferator-activated receptor gamma/0.445
2cig1DGDihydrofolate reductase1.5.1.30.445
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2vkeTACTetracycline repressor protein class D/0.445
3wv9FEGHmd co-occurring protein HcgE/0.445
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.444
3ibdCPZCytochrome P450 2B61.14.130.444
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.444
2ejzSAHDiphthine synthase/0.443
2he5NDPAldo-keto reductase family 1 member C211.1.10.443
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.443
3zuyTCHTransporter/0.443
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4q71FADBifunctional protein PutA/0.443
1ha3MAUElongation factor Tu-A/0.442
2a7r5GPGMP reductase 2/0.442
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2ejvNADL-threonine 3-dehydrogenase/0.442
2q9fC3SCholesterol 24-hydroxylase/0.442
3mdmFJZCholesterol 24-hydroxylase/0.442
5hs1VORLanosterol 14-alpha demethylase/0.442
1xe65FPPlasmepsin-23.4.23.390.441
2gjnFMNNitronate monooxygenase1.13.12.160.441
2q61SF1Peroxisome proliferator-activated receptor gamma/0.441
4bfwZVWPantothenate kinase2.7.1.330.441
2fznFADBifunctional protein PutA1.5.5.20.440
2g226IGRenin3.4.23.150.440
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
3sgtP09Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)/0.440