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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3a37ADPATPase GET3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3a37ADPATPase GET3/1.000
2g1r3IGRenin3.4.23.150.496
3kb1ADPIron-sulfur cluster carrier protein/0.486
2g1s4IGRenin3.4.23.150.473
1xe55FEPlasmepsin-23.4.23.390.468
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.468
3tneRITCandidapepsin-13.4.23.240.468
1f8wFADNADH peroxidase1.11.1.10.466
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.466
3ieuGDPGTPase Era/0.465
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.462
3qe2FMNNADPH--cytochrome P450 reductase/0.459
4jtqNAPAldo-keto reductase family 1 member C2/0.458
3fsuFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.457
3hl0NADMaleylacetate reductase/0.456
2iko7IGRenin3.4.23.150.455
1w5sADPORC1-type DNA replication protein 2/0.454
4dzzADPPlasmid partitioning protein ParF/0.454
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.453
3hyoADPPyridoxal kinase/0.452
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.450
1xddAAYIntegrin alpha-L/0.449
2g8yNADHydroxycarboxylate dehydrogenase B/0.449
3b70NAPEnoyl reductase LovC10.449
4dfg0JVGag-Pol polyprotein3.4.23.160.448
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.448
1nhqFADNADH peroxidase1.11.1.10.447
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.447
2i4qUA4Renin3.4.23.150.447
3h06VBPGlutamate receptor 2/0.447
1zp3FAD5,10-methylenetetrahydrofolate reductase1.5.1.200.446
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.445
2ien017Gag-Pol polyprotein3.4.23.160.445
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.445
1w6hTITPlasmepsin-23.4.23.390.443
4ambDUDPutative glycosyl transferase/0.443
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.443
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
2ikuLIYRenin3.4.23.150.442
2y0mACOHistone acetyltransferase KAT8/0.442
2yxuATPPyridoxal kinase2.7.1.350.442
3tjzGNPADP-ribosylation factor 1/0.442
1bxoPP7Penicillopepsin-13.4.23.200.441
1jqiFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.441
2futH1SHeparin and heparin-sulfate lyase/0.441
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.441
3mk6ACOPantothenate kinase 32.7.1.330.441
3nsh957Beta-secretase 13.4.23.460.441
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.441
4i0i957Beta-secretase 13.4.23.460.441
4y3jHICEndothiapepsin3.4.23.220.441
1me6IVSPlasmepsin-23.4.23.390.440
2givACOHistone acetyltransferase KAT8/0.440
2zjmF1MBeta-secretase 13.4.23.460.440
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.440
4o8aFADBifunctional protein PutA1.2.1.880.440