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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2zuiCAMCamphor 5-monooxygenase1.14.15.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2zuiCAMCamphor 5-monooxygenase1.14.15.11.000
2zawCAMCamphor 5-monooxygenase1.14.15.10.758
3fwiCAMCamphor 5-monooxygenase1.14.15.10.731
3fwgCAMCamphor 5-monooxygenase1.14.15.10.691
1dz4CAMCamphor 5-monooxygenase1.14.15.10.675
2zaxCAMCamphor 5-monooxygenase1.14.15.10.674
1t87CAMCamphor 5-monooxygenase1.14.15.10.672
1yrdCAMCamphor 5-monooxygenase1.14.15.10.671
3wrmCAMCamphor 5-monooxygenase1.14.15.10.669
3wrhCAMCamphor 5-monooxygenase1.14.15.10.668
1t88CAMCamphor 5-monooxygenase1.14.15.10.666
3wrlCAMCamphor 5-monooxygenase1.14.15.10.666
3fwfCAMCamphor 5-monooxygenase1.14.15.10.665
1uyuCAMCamphor 5-monooxygenase1.14.15.10.662
3wrjCAMCamphor 5-monooxygenase1.14.15.10.661
1nooCAHCamphor 5-monooxygenase1.14.15.10.659
3fwjCAMCamphor 5-monooxygenase1.14.15.10.656
2m56CAMCamphor 5-monooxygenase1.14.15.10.652
3l63CAMCamphor 5-monooxygenase1.14.15.10.651
4l49CAMCamphor 5-monooxygenase1.14.15.10.650
2a1nCAMCamphor 5-monooxygenase1.14.15.10.649
4g3rCAMCamphor 5-monooxygenase1.14.15.10.647
4l4aCAMCamphor 5-monooxygenase1.14.15.10.645
1t86CAMCamphor 5-monooxygenase1.14.15.10.644
4kkyCAMCamphor 5-monooxygenase1.14.15.10.644
6cp4CAMCamphor 5-monooxygenase1.14.15.10.642
2feuCAMCamphor 5-monooxygenase1.14.15.10.640
4l4fCAMCamphor 5-monooxygenase1.14.15.10.639
5cp4CAMCamphor 5-monooxygenase1.14.15.10.637
2a1mCAMCamphor 5-monooxygenase1.14.15.10.635
1t85CAMCamphor 5-monooxygenase1.14.15.10.634
4l4eCAMCamphor 5-monooxygenase1.14.15.10.633
2qblCAMCamphor 5-monooxygenase1.14.15.10.630
2qboCAMCamphor 5-monooxygenase1.14.15.10.630
1o76CAMCamphor 5-monooxygenase1.14.15.10.628
2a1oCAMCamphor 5-monooxygenase1.14.15.10.628
1yrcCAMCamphor 5-monooxygenase1.14.15.10.627
2qbmCAMCamphor 5-monooxygenase1.14.15.10.627
4l4bCAMCamphor 5-monooxygenase1.14.15.10.627
1iwiCAMCamphor 5-monooxygenase1.14.15.10.625
4ek1CAMCamphor 5-monooxygenase1.14.15.10.624
1dz8CAMCamphor 5-monooxygenase1.14.15.10.622
4l4cCAMCamphor 5-monooxygenase1.14.15.10.617
4l4dCAMCamphor 5-monooxygenase1.14.15.10.615
4cp4CAMCamphor 5-monooxygenase1.14.15.10.611
1iwjCAMCamphor 5-monooxygenase1.14.15.10.610
2cppCAMCamphor 5-monooxygenase1.14.15.10.607
1phgMYTCamphor 5-monooxygenase1.14.15.10.604
2qbnCAMCamphor 5-monooxygenase1.14.15.10.601
4jx1CAMCamphor 5-monooxygenase1.14.15.10.601
1gebCAMCamphor 5-monooxygenase1.14.15.10.599
3cppCAMCamphor 5-monooxygenase1.14.15.10.593
4jx1CAHCamphor 5-monooxygenase1.14.15.10.593
3lxiCAMCytochrome P450/0.586
2z97CAMCamphor 5-monooxygenase1.14.15.10.564
3mdmFJZCholesterol 24-hydroxylase/0.552
5hs1VORLanosterol 14-alpha demethylase/0.537
1rf9DBRCamphor 5-monooxygenase1.14.15.10.536
4c9pCAMCytochrome P450/0.536
1dz6CAMCamphor 5-monooxygenase1.14.15.10.535
1jioDEB6-deoxyerythronolide B hydroxylase/0.534
4g3jVNTLanosterol 14-alpha-demethylase/0.534
1phePIYCamphor 5-monooxygenase1.14.15.10.533
3gw9VNILanosterol 14-alpha-demethylase/0.522
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.521
1jipKTN6-deoxyerythronolide B hydroxylase/0.518
4lhtCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.518
4uymVOR14-alpha sterol demethylase Cyp51B/0.516
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.511
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.506
1eupASD6-deoxyerythronolide B hydroxylase/0.505
4enhFVXCholesterol 24-hydroxylase/0.504
4i8vBHFCytochrome P450 1A11.14.14.10.500
3ibdCPZCytochrome P450 2B61.14.130.495
3p99LNPLanosterol 14-alpha-demethylase/0.495
4tuvCPZCytochrome P450 1191.140.492
3t3r9PLCytochrome P450 2A61.14.130.491
4j6cSTRCytochrome P450 monooxygenase/0.491
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.489
4r20AERCytochrome P450 family 17 polypeptide 2/0.488
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.486
3gwfNAPCyclohexanone monooxygenase/0.484
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.484
3f03FMNPentaerythritol tetranitrate reductase/0.483
4y8wSTRSteroid 21-hydroxylase/0.483
1bwsNDPGDP-L-fucose synthase/0.482
3p3zP3ZPutative cytochrome P450/0.481
3p62FMNPentaerythritol tetranitrate reductase/0.480
3s79ASDAromatase1.14.14.140.480
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.480
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.478
1suoCPZCytochrome P450 2B41.14.14.10.477
3a1l2CCCytochrome P450/0.477
3s1dZIRCytokinin dehydrogenase 11.5.99.120.476
1h50FMNPentaerythritol tetranitrate reductase/0.475
2z3uCRRCytochrome P450/0.474
4g7gVFVLanosterol 14-alpha-demethylase/0.474
4qq3XMPInosine-5'-monophosphate dehydrogenase/0.474
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.473
2zbaZBATrichothecene 3-O-acetyltransferase/0.473
4ejh0QACytochrome P450 2A131.14.14.10.472
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.472
2ft9CHDFatty acid-binding protein 2, liver/0.471
3p8jFMNPentaerythritol tetranitrate reductase/0.471
4c9oCAMCytochrome P450/0.471
4j6bPLOCytochrome P450 monooxygenase/0.471
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.470
3lqfNADGalactitol dehydrogenase/0.469
3tk3CPZCytochrome P450 2B41.14.14.10.469
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
1vyrFMNPentaerythritol tetranitrate reductase/0.468
2vn0TDZCytochrome P450 2C8/0.468
1fmjRTLRetinol dehydratase/0.467
1fmlRTLRetinol dehydratase/0.467
1jolFFODihydrofolate reductase1.5.1.30.466
4e5yNDPGDP-L-fucose synthase1.1.1.2710.466
1dyjDDFDihydrofolate reductase1.5.1.30.465
2x0iNAIMalate dehydrogenase/0.465
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.465
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.463
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
4n6hEJ4Delta-type opioid receptor/0.462
1dhjMTXDihydrofolate reductase1.5.1.30.461
1dyiFOLDihydrofolate reductase1.5.1.30.461
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.461
4b7dQLECytochrome P450 monooxygenase PikC/0.461
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
1h51FMNPentaerythritol tetranitrate reductase/0.460
4egnTWOCytochrome P450/0.460
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.460
4ly91YYGlucokinase regulatory protein/0.460
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.460
3atzFMNProstaglandin F2a synthase/0.459
3ixp834Ecdysone receptor/0.459
3p8iFMNPentaerythritol tetranitrate reductase/0.459
2j07HDFDeoxyribodipyrimidine photo-lyase4.1.99.30.458
1fxsNAPGDP-L-fucose synthase/0.457
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.457
4i1nFOLDihydrofolate reductase1.5.1.30.457
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
3wecAUICytochrome P450/0.456
1xe65FPPlasmepsin-23.4.23.390.455
3t3q9PLCytochrome P450 2A61.14.130.455
4ipw1G7Mycocyclosin synthase1.14.21.90.455
4k6fNAPPutative Acetoacetyl-CoA reductase/0.455
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
2abbFMNPentaerythritol tetranitrate reductase/0.454
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
2z0ySAMRibosomal RNA small subunit methyltransferase E/0.453
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.453
3k4nFADPyranose 2-oxidase/0.453
3oqfS51Renin3.4.23.150.453
3p74FMNPentaerythritol tetranitrate reductase/0.453
3q9bB3NAcetylpolyamine amidohydrolase/0.453
4djaFAD(6-4) photolyase/0.453
1rb2FOLDihydrofolate reductase1.5.1.30.452
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.452
2y3rTRKTamL/0.452
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.452
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.452
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
3qm4PN0Cytochrome P450 2D6/0.452
4bb3KKAIsopenicillin N synthase1.21.3.10.452
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
4q73FADBifunctional protein PutA/0.452
4tqgNDPPutative dTDP-d-glucose 4 6-dehydratase/0.452
1g6kNADGlucose 1-dehydrogenase1.1.1.470.451
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.451
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.451
2dftADPShikimate kinase2.7.1.710.451
2vkeTACTetracycline repressor protein class D/0.451
2vwqNAPGlucose 1-dehydrogenase/0.451
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.451
3nr4PYVAbscisic acid receptor PYL2/0.451
4m83ERYOleandomycin glycosyltransferase2.4.10.451
4oqyNDP(S)-imine reductase/0.451
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.450
1x8lOXRRetinol dehydratase/0.450
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.450
2npxNADNADH peroxidase1.11.1.10.450
4i6gFADCryptochrome-2/0.450
4j6dTESCytochrome P450 monooxygenase/0.450
4lcg1WMUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.450
1bsvNDPGDP-L-fucose synthase/0.449
1dbvNADGlyceraldehyde-3-phosphate dehydrogenase/0.449
1q5dEPBEpothilone C/D epoxidase1.140.449
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.449
1k7fIAVTryptophan synthase alpha chain/0.448
1rf7DHFDihydrofolate reductase1.5.1.30.448
2o4cNADErythronate-4-phosphate dehydrogenase/0.448
2rhrEMOPutative ketoacyl reductase1.3.10.448
3p84FMNPentaerythritol tetranitrate reductase/0.448
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4zowCLMMultidrug transporter MdfA/0.448
1vzaUMPThymidylate synthase/0.447
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
2iko7IGRenin3.4.23.150.447
2w6zL21Biotin carboxylase6.3.4.140.447
3mk6ACOPantothenate kinase 32.7.1.330.447
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.447
4g95OAGDihydrofolate reductase1.5.1.30.447
4nxuADPMitochondrial dynamics protein MID51/0.447
1dyhDZFDihydrofolate reductase1.5.1.30.446
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.446
2w2lNADD-mandelate dehydrogenase/0.446
4dfrMTXDihydrofolate reductase1.5.1.30.446
4j16NADNAD/NADP transhydrogenase alpha subunit 1/0.446
4q71FADBifunctional protein PutA/0.446
4v2gITCTetracycline repressor protein class D/0.446
1e7qNAPGDP-L-fucose synthase/0.445
3p67FMNPentaerythritol tetranitrate reductase/0.445
3w2nRODDihydroorotate dehydrogenase (fumarate)1.3.98.10.445
4gdcNDPUDP-galactopyranose mutase/0.445
4gk3L87Ephrin type-A receptor 32.7.10.10.445
1nvtNAPShikimate dehydrogenase (NADP(+))/0.444
1t2bCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.444
1t2cNAIL-lactate dehydrogenase1.1.1.270.444
2iyfERYOleandomycin glycosyltransferase2.4.10.444
3p82FMNPentaerythritol tetranitrate reductase/0.444
4b1rITCTetracycline repressor protein class D/0.444
4bfxZVXPantothenate kinase2.7.1.330.444
4q72FADBifunctional protein PutA/0.444
5a0112VO-glycosyltransferase/0.444
1bwlFMNNADPH dehydrogenase 11.6.99.10.443
1dr3HBIDihydrofolate reductase1.5.1.30.443
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.443
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1gpdNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.443
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.443
2drcMTXDihydrofolate reductase1.5.1.30.443
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.443
3qt62P0Mevalonate diphosphate decarboxylase/0.443
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.443
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.443
1g1aNADdTDP-glucose 4,6-dehydratase/0.442
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
2cy0NAPShikimate dehydrogenase (NADP(+))/0.442
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3mdvCL6Cholesterol 24-hydroxylase/0.442
3w1tWRODihydroorotate dehydrogenase (fumarate)1.3.98.10.442
4ktl1CQCytochrome P450/0.442
4yaoFMNNADPH--cytochrome P450 reductase/0.442
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1bw9NADPhenylalanine dehydrogenase/0.441
1rb3MTXDihydrofolate reductase1.5.1.30.441
1u0hFOKAdenylate cyclase type 2/0.441
1u0hFOKAdenylate cyclase type 5/0.441
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.441
2j08IRFDeoxyribodipyrimidine photo-lyase4.1.99.30.441
2vtbFADCryptochrome DASH, chloroplastic/mitochondrial/0.441
3drcMTXDihydrofolate reductase1.5.1.30.441
3hl0NADMaleylacetate reductase/0.441
3r9uFADThioredoxin reductase/0.441
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
4kbyC2EStimulator of interferon genes protein/0.441
5a3bAPRSIR2 family protein/0.441
3sn6P0GBeta-2 adrenergic receptor/0.441
1np7FADCryptochrome DASH/0.440
1xddAAYIntegrin alpha-L/0.440
2xpuTDCTetracycline repressor protein class D/0.440
2y3sTIRTamL/0.440
3nj0PYVAbscisic acid receptor PYL2/0.440
4lt63ATPoly(A) polymerase gamma2.7.7.190.440