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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2zscBTNTamavidin2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2zscBTNTamavidin2/1.000
1mepBTNStreptavidin/0.558
1swnBTNStreptavidin/0.552
1sweBTNStreptavidin/0.548
4bx7B4FStreptavidin/0.545
3wypBSOStreptavidin/0.542
1n43BTNStreptavidin/0.539
1swpBTQStreptavidin/0.538
1stpBTNStreptavidin/0.532
1swpBTNStreptavidin/0.531
1ndjBTNStreptavidin/0.530
1sriDMBStreptavidin/0.530
1swdBTNStreptavidin/0.524
1n9mBTNStreptavidin/0.521
1srgMHBStreptavidin/0.521
1nc9IMIStreptavidin/0.517
2izhBTNStreptavidin/0.515
2fhnBNIAvidin-related protein 4/5/0.509
4bj8BTNAvidin/0.507
2rtoIMIStreptavidin/0.504
4yvbBTNStreptavidin/0.497
2rtdBTNStreptavidin/0.496
2izlIMIStreptavidin/0.493
2rtgBTNStreptavidin/0.492
4gd9BTNStreptavidin/0.492
2izfBTNStreptavidin/0.490
1lcwSHMStreptavidin/0.489
2rtfBTNStreptavidin/0.487
1df8BTNStreptavidin/0.485
1mk5BTNStreptavidin/0.485
2aviBTNAvidin/0.485
3vhhVHHAvidin/0.484
1swtBTNStreptavidin/0.482
2rtrIMIStreptavidin/0.482
3wznBTNStreptavidin/0.481
1swrBTNStreptavidin/0.480
4pnmNU1Tankyrase-22.4.2.300.479
1nqmBTNStreptavidin/0.478
2rtqIMIStreptavidin/0.478
4an4DUDPutative glycosyl transferase/0.478
1sreHABStreptavidin/0.477
2rteBTNStreptavidin/0.477
1srfMTBStreptavidin/0.476
1srhMOBStreptavidin/0.476
4dneDTBStreptavidin/0.476
4bb3KKAIsopenicillin N synthase1.21.3.10.475
1srjNABStreptavidin/0.473
3ry2BTNStreptavidin/0.473
2rtnIMIStreptavidin/0.471
2hq9FADMll6688 protein/0.470
2y3fBTNStreptavidin/0.470
3vgwNVZAvidin/0.469
1hb3SCVIsopenicillin N synthase1.21.3.10.468
2izgBTNStreptavidin/0.468
1avdBTNAvidin/0.466
4dvi2IWTankyrase-12.4.2.300.466
5k2cZMAAdenosine receptor A2a/0.465
5jtbZMAAdenosine receptor A2a/0.465
1hb1OCVIsopenicillin N synthase1.21.3.10.463
2jb4A14Isopenicillin N synthase1.21.3.10.463
1rxhBNIStreptavidin/0.462
2rtmIMIStreptavidin/0.462
2vbpVB1Isopenicillin N synthase1.21.3.10.461
4ocvANPAminoglycoside phosphotransferase/0.461
2rtpIMIStreptavidin/0.460
2uz2BTNAvd protein/0.458
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
2vczVC3Hematopoietic prostaglandin D synthase/0.457
3zoiM2WIsopenicillin N synthase1.21.3.10.457
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.456
2xlpFADPutative flavin-containing monooxygenase/0.454
3d4bDZDNAD-dependent protein deacetylase/0.454
4bcsBTNAvidin-related protein 4/5/0.454
1i9hBNIStreptavidin/0.453
1y52BTNAvidin-related protein 4/5/0.453
3zkyWT4Isopenicillin N synthase1.21.3.10.453
1pqc444Oxysterols receptor LXR-beta/0.452
2iviACWIsopenicillin N synthase1.21.3.10.452
2wo7ASVIsopenicillin N synthase1.21.3.10.452
3t2wBTNAvidin/streptavidin/0.452
3up0D7SaceDAF-12/0.452
1luqBTNStreptavidin/0.451
3vtdTKDVitamin D3 receptor/0.451
4z28BTNHoefavidin/0.451
1bk0ACVIsopenicillin N synthase1.21.3.10.450
1qjfACSIsopenicillin N synthase1.21.3.10.450
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.450
3sfi3SFHTH-type transcriptional regulator EthR/0.449
3emlZMAAdenosine receptor A2a/0.449
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
4iae1DXAlr2278 protein/0.448
2iziBTNStreptavidin/0.447
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.446
1kceCB3Thymidylate synthase/0.446
2c4iBTNAvidin/0.446
3o8gO8GHTH-type transcriptional regulator EthR/0.446
3uyk0CXProbable NDP-rhamnosyltransferase/0.446
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.445
1hqtNAPAlcohol dehydrogenase [NADP(+)]1.1.1.20.445
1o5rFR9Adenosine deaminase3.5.4.40.445
2y6fM9FIsopenicillin N synthase1.21.3.10.445
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.445
2jgsBTNAvidin/0.444
4bfsZVSPantothenate kinase2.7.1.330.444
4fhpUTPTerminal uridylyltransferase cid1/0.444
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.444
7catNDPCatalase1.11.1.60.444
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.443
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.443
1s3uTQDDihydrofolate reductase1.5.1.30.442
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.442
2xtbKRMAdenosine kinase, putative/0.442
3n0hTOPDihydrofolate reductase1.5.1.30.442
4ggzBTNBll1558 protein/0.442
5fm7ADPRuvB-like helicase/0.442
1powFADPyruvate oxidase1.2.3.30.441
1qiqACCIsopenicillin N synthase1.21.3.10.441
4giy0WYQueuine tRNA-ribosyltransferase2.4.2.290.441
4l5b1UXDeoxycytidine kinase2.7.1.740.441
4twnB96Ephrin type-A receptor 32.7.10.10.441
5iu86DZAdenosine receptor A2a/0.441
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1p8dCO1Oxysterols receptor LXR-beta/0.440
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.440
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.440
3u9y09LTankyrase-22.4.2.300.440
3ukoNADAlcohol dehydrogenase class-3/0.440
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.440
5jlaNADPutative short-chain dehydrogenase/reductase/0.440