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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2zhf49UProthrombin3.4.21.5

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2zhf49UProthrombin3.4.21.51.000
2zda32UProthrombin3.4.21.50.828
2zfr46UProthrombin3.4.21.50.796
2zg050UProthrombin3.4.21.50.777
2zgx29UProthrombin3.4.21.50.775
2zc922UProthrombin3.4.21.50.769
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.767
2zdv37UProthrombin3.4.21.50.745
3biu10UProthrombin3.4.21.50.743
2zhq27UProthrombin3.4.21.50.742
2zi224UProthrombin3.4.21.50.734
2zhe13UProthrombin3.4.21.50.728
2znk31UProthrombin3.4.21.50.723
2zfp19UProthrombin3.4.21.50.716
4ax9N5NProthrombin3.4.21.50.715
2zff53UProthrombin3.4.21.50.713
3dux64UProthrombin3.4.21.50.712
2v3oI26Prothrombin3.4.21.50.704
2zgb21UProthrombin3.4.21.50.704
3eq02TSProthrombin3.4.21.50.701
2r2mI50Prothrombin3.4.21.50.698
1d4pBPPProthrombin3.4.21.50.695
2zfq45UProthrombin3.4.21.50.684
1nm6L86Prothrombin3.4.21.50.683
2zhw12UProthrombin3.4.21.50.676
1ypeUIPProthrombin3.4.21.50.672
2bdyUNBProthrombin3.4.21.50.670
3qto10PProthrombin3.4.21.50.670
3dhk23UProthrombin3.4.21.50.667
2jh5895Prothrombin3.4.21.50.665
1d3dBZTProthrombin3.4.21.50.662
2jh6894Prothrombin3.4.21.50.657
1ypgUIRProthrombin3.4.21.50.656
3qwc98PProthrombin3.4.21.50.655
1c4uIH1Prothrombin3.4.21.50.652
2anmCDOProthrombin3.4.21.50.650
1xm1GAHProthrombin3.4.21.50.649
1z71L17Prothrombin3.4.21.50.647
3p1799PProthrombin3.4.21.50.638
4baoMVFProthrombin3.4.21.50.638
3biv11UProthrombin3.4.21.50.635
1sb1165Prothrombin3.4.21.50.634
1jwtBLIProthrombin3.4.21.50.633
1t4v14AProthrombin3.4.21.50.633
1ypjUIBProthrombin3.4.21.50.633
2ziq26UProthrombin3.4.21.50.633
1k21IGNProthrombin3.4.21.50.631
2uuk897Prothrombin3.4.21.50.629
2zf051UProthrombin3.4.21.50.629
4bahMELProthrombin3.4.21.50.629
1ypmRA4Prothrombin3.4.21.50.628
1mueCDDProthrombin3.4.21.50.626
1t4u81AProthrombin3.4.21.50.626
4bamMM9Prothrombin3.4.21.50.625
4ayy9MXProthrombin3.4.21.50.623
1d3pBT3Prothrombin3.4.21.50.622
2pksG44Prothrombin3.4.21.50.621
1c4yIH3Prothrombin3.4.21.50.619
1mu6CDAProthrombin3.4.21.50.619
7kmeACE_0BN_CHG_PRRProthrombin3.4.21.50.618
1ae8AZLProthrombin3.4.21.50.615
1yplRA8Prothrombin3.4.21.50.615
4bakM67Prothrombin3.4.21.50.615
4n3l2FNProthrombin3.4.21.50.613
4lxb7R9Prothrombin3.4.21.50.609
1afeALZProthrombin3.4.21.50.606
3c27DKKProthrombin3.4.21.50.605
1ypkCCRProthrombin3.4.21.50.603
1d6w00RProthrombin3.4.21.50.601
2bvs2CEProthrombin3.4.21.50.599
1zgv501Prothrombin3.4.21.50.598
2cf8ESHProthrombin3.4.21.50.598
1d9i00PProthrombin3.4.21.50.596
2cf9348Prothrombin3.4.21.50.596
4rn615UProthrombin3.4.21.50.595
1zrb062Prothrombin3.4.21.50.593
3c1kT15Prothrombin3.4.21.50.592
1oytFSNProthrombin3.4.21.50.590
2jh0701Prothrombin3.4.21.50.588
1ta6177Prothrombin3.4.21.50.586
1k22MELProthrombin3.4.21.50.585
2cn0F25Prothrombin3.4.21.50.583
1a4wQWEProthrombin3.4.21.50.581
3qtv06PProthrombin3.4.21.50.581
4banM6SProthrombin3.4.21.50.579
1vzqSHYProthrombin3.4.21.50.575
2v3hI25Prothrombin3.4.21.50.574
2gdeSN3Prothrombin3.4.21.50.566
3utu1TSProthrombin3.4.21.50.565
1c4vIH2Prothrombin3.4.21.50.558
2uuj896Prothrombin3.4.21.50.558
1o0d163Prothrombin3.4.21.50.554
4az29MUProthrombin3.4.21.50.552
4baqM4ZProthrombin3.4.21.50.551
4e7r0NWProthrombin3.4.21.50.551
1nzq162Prothrombin3.4.21.50.549
1ghv120Prothrombin3.4.21.50.546
3egkM18Prothrombin3.4.21.50.541
1w7gMIUProthrombin3.4.21.50.540
1zgi382Prothrombin3.4.21.50.539
1mu8CDBProthrombin3.4.21.50.531
4ayv9MQProthrombin3.4.21.50.531
4hfp15UProthrombin3.4.21.50.529
1riwOSCProthrombin3.4.21.50.528
1gj5130Prothrombin3.4.21.50.527
1uvsI11Prothrombin3.4.21.50.521
1c5nESIProthrombin3.4.21.50.514
1o2g696Prothrombin3.4.21.50.508
1gj4132Prothrombin3.4.21.50.507
5cmx0G6Prothrombin3.4.21.50.506
1bcuPRLProthrombin3.4.21.50.503
1ktsC24Prothrombin3.4.21.50.502
3f6891UProthrombin3.4.21.50.501
4loy6XSProthrombin3.4.21.50.491
1ny2ARG_PRO_PRO_GLYProthrombin3.4.21.50.488
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.488
2bxtC2DProthrombin3.4.21.50.486
2a2xNA9Prothrombin3.4.21.50.484
4kbyC2EStimulator of interferon genes protein/0.481
1ta2176Prothrombin3.4.21.50.474
4xguADPPutative pachytene checkpoint protein 2/0.458
1o5gCR9Prothrombin3.4.21.50.454
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.452
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.448
8catNDPCatalase1.11.1.60.448
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.446
3vqsJT1Genome polyprotein/0.444
1umaIN2Prothrombin3.4.21.50.442
5dozNDPJamJ/0.442
4b1jA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.440