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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2zb3NDPProstaglandin reductase 21.3.1.48

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2zb3NDPProstaglandin reductase 21.3.1.481.000
2vnaNAPProstaglandin reductase 21.3.1.480.612
2y05NAPProstaglandin reductase 1/0.545
4b7xNAPProbable oxidoreductase/0.536
2j3iNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.519
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.518
2j3kNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.513
2c0cNAPProstaglandin reductase 310.510
3jynNDPQuinone oxidoreductase/0.467
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.454
2obyNAPQuinone oxidoreductase PIG310.449